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Clinical and Immunological Features Associated with Bovine Leukocyte Adhesion Deficiency

  • Conference paper
Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

Abstract

Granulocytopathies in dogs (1), humans (2), and cattle (3,4) characterized by persistent progressive neutrophilia in patients affected with severe recurrent bacterial infections and failure to form pus were reported between 1975 and 1987. In all three species, these conditions were determined to be heritable deficiencies of leukocyte surface glycoproteins associated with diminished cell adherence between 1984 and 1990 (5–9). Although published reports of its diagnosis are few, the bovine granulocy-topathy syndrome has been diagnosed at veterinary schools throughout the world during the past 8 y. In vitro assessments have identified abnormalities of motile, phagocytic, and oxidative functions of neutrophils which appear to mediate inflammatory deficits in vivo (3,4,7,8). Factors contributing to low frequency of diagnosis of this syndrome may relate to the impracticality of intensive clinical laboratory studies in food-producing animal species.

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Authors
  1. Marcus E. Kehrli Jr.
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  2. Dale E. Shuster
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  3. Mark Ackermann
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  4. C. Wayne Smith
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  5. Donald C. Anderson
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  6. Monique Doré
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  7. Bonnie J. Hughes
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Editor information

Editors and Affiliations

  1. Internal Medicine and Microbiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX, 75235-8884, USA

    Peter E. Lipsky M.D. (Professor) (Professor)

  2. Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Robert Rothlein Ph.D. (Distinguished Scientist) & Takashi Kei Kishimoto Ph.D. (Senior Scientist) (Distinguished Scientist) &  (Senior Scientist)

  3. R&D Scientific and Technical Operations, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Ronald B. Faanes Ph.D. (Director) (Director)

  4. Department of Pediatrics Leukocyte Biology Section, Texas Children’s Hospital Clinical Care Center, Suite 1130 6621 Fannin, MC 3-3272, Houston, TX, 77030-2399, USA

    C. Wayne Smith Ph.D. (Professor) (Professor)

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© 1993 Springer-Verlag New York Inc.

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Kehrli, M.E. et al. (1993). Clinical and Immunological Features Associated with Bovine Leukocyte Adhesion Deficiency. In: Lipsky, P.E., Rothlein, R., Kishimoto, T.K., Faanes, R.B., Smith, C.W. (eds) Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9266-8_27

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  • DOI: https://doi.org/10.1007/978-1-4613-9266-8_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9268-2

  • Online ISBN: 978-1-4613-9266-8

  • eBook Packages: Springer Book Archive

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