Summary
In these studies we have demonstrated that noninvolved mammary tissue obtained from a breast containing a tumor showed increased FTP binding activity of ras-P21and increased 16α-hydroxylation of estradiol relative to the level in normal breast tissue. In addition, a hyper response in the levels of both parameters was observed following treatment of the tumor-related breast tissue in organ culture with benzopyrene and/or fatty acids. The results suggest that the apparently normal breast tissue from a cancerous breast is biochemically different from breast tissue taken from a normal breast (mammoplasty). The shifts in these parameters after both treatments are in the direction associated with increased cancer risk.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Telang NT, Axelrod DM, Wing GY, Bradlow HL, Osborne MP (1991) Biotransformation of estradiol by explant cultures of human mammary tissue. Steroids 56: 37–43.
Telang NT, Bradlow HL, Kurihara H, and Osborne MP (1991) In Vitro Transformation of estradiol by explant cultures of murine mammary tissues. Breast Cancer Res and Treatment 13:173–181.
Telang NT, Basu A, Kukrihara H, Osborne MP, & Modak MJ (1988) Modulation in the expression of murine mammary tumor virus, ras protooncogene and of alveolar hyperplasia by fatty acids in mouse mammary explant cultures. Anticancer Res 8: 971–976.
Telang NT, Narayanan R, Bradlow HL, Osborne MP (1991) Coordinated expression of intermediate biomarkers for tumorigenic transformation in ras-transfected mouse mammary epithelial cells. Breast Cancer Res and Treatment (in press).
Schneider J, Kinne D, Fracchia A, Pierce V, Anderson KE, Bradlow HL, & Fishman J (1982) Abnormal oxidative metabolism of estradiol in women with breast cancer. Proc Natl Acad Sci USA 79P: 3047–3051.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag New York, Inc.
About this paper
Cite this paper
Bradlow, H.L., Osborne, M., Michnovicz, J.J., Telang, N.T. (1992). Modulation of Estrogen Metabolism by Inducers of P-4501A2: Possible Application to the Chemoprevention of Breast Cancer. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_33
Download citation
DOI: https://doi.org/10.1007/978-1-4613-9208-8_33
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-9210-1
Online ISBN: 978-1-4613-9208-8
eBook Packages: Springer Book Archive