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Hormonal Carcinogenesis

Proceedings of the First International Symposium

  • Jonathan J. Li
  • Satyabrata Nandi
  • Sara Antonia Li

Table of contents

  1. Front Matter
    Pages i-xxxiv
  2. Symposium Presentation

  3. Sex Hormones and Carcinogenesis

    1. Front Matter
      Pages 9-9
    2. Shutsung Liao
      Pages 11-17
    3. Tomoyuki Shirai, Seiko Tamano, Shogo Iwasaki, Nobuyuki Ito
      Pages 27-32
    4. James S. Norris, David A. Schwartz, Tina Cooper, Weimin Fan
      Pages 33-40
  4. Hormones, Cell Proliferation, and Carcinogenesis

    1. Front Matter
      Pages 41-41
    2. Elwood V. Jensen
      Pages 43-50
    3. John A. McLachlan, Retha R. Newbold, Karen G. Nelson, Kenneth S. Korach
      Pages 51-57
    4. Alberto Baldi, Denis M. Boyle, Nestor V. Annibali, James L. Wittliff
      Pages 58-64
    5. Craig W. Beattie, Conwell H. Anderson
      Pages 65-72
    6. Satyabrata Nandi, Raphael C. Guzman, Shigeki Miyamoto
      Pages 73-77
  5. Estrogen Metabolism and Carcinogenicity

    1. Front Matter
      Pages 79-79
    2. Allan H. Conney, Lisa A. Suchar, Shuzo Okumura, Richard L. Chang
      Pages 81-85
    3. Manfred Metzler, Erika Pfeiffer, Werner Köhl, Robert Schnitzler
      Pages 86-94
  6. Hormones and Tumor Promotion

    1. Front Matter
      Pages 119-119
    2. Leonard J. Lerner
      Pages 121-123
    3. Christopher Liddle, Catherine Legraverend, Agneta Blanck, Inger Porsch-Hällström, Agneta Mode, Jan-Åke Gustafsson
      Pages 124-129
    4. Eduardo H. Charreau, Patricia Elizalde, Fabiana Guerra, Claudia Lanari, Edith Kordon, Christiane Dosne Pasqualini
      Pages 138-144
    5. Frederique Kuttenn, Anne Gompel, Catherine Malet, Etienne Leygue, Nicole Baudot, Geneviere Plu et al.
      Pages 145-156
  7. Growth Factors and Oncogenes

    1. Front Matter
      Pages 157-157
    2. J. Carl Barrett
      Pages 159-163
    3. Nancy E. Hynes, M. Caitriona NicMhuiris, Urs Stiefel, Daniela Taverna, Roland Ball, Brigitte Happ et al.
      Pages 164-171
    4. Richard P. DiAugustine, Suzanne M. Snedeker, Gloria D. Jahnke
      Pages 172-181
    5. Stephen E. Harris, Zeng X. Rong, Jeffrey A. Hall, Murray A. Harris, James S. Norris, Roy G. Smith et al.
      Pages 182-192
    6. Salman M. Hyder, Connie Chiappetta, John L. Kirkland, Tsu-Hui Lin, David S. Loose-Mitchell, Lata Murthy et al.
      Pages 193-200
  8. Carcinogenesis Risk Assessment of Sex Hormones

  9. Closing Remarks

    1. Front Matter
      Pages 235-235
    2. Gerald C. Mueller
      Pages 237-244
  10. Communications

    1. Front Matter
      Pages 245-245
    2. Sushanta K. Banerjee, Snigdha Banerjee, Sara Antonia Li, Jonathan J. Li
      Pages 247-250
    3. Agneta Blanck, Jan-Åke Gustafsson, Inger Porsch-Hällström
      Pages 251-253
    4. H. Leon Bradlow, Michael Osborne, Jon J. Michnovicz, Nitin T. Telang
      Pages 254-258
    5. Robert W. Brueggemeier, Mustapha A. Beleh, Denise L. Donley, Young C. Lin
      Pages 259-262
    6. Pat Cody
      Pages 268-271
    7. Bruno de Lignieres, Jacques Barrat, Sabine Fournier, Kahil Nahoul, Gustavo Linares, Genevieve Contesso
      Pages 277-279
    8. Richard P. DiAugustine, Michael Walker, Sara Antonia Li, Jonathan J. Li
      Pages 280-284
    9. Raphael C. Guzman, Rebecca C. Osborn, Shigeki Miyamoto, Ramasamy Sakthivel, Soo-In Hwang, Satyabrata Nandi
      Pages 285-287

About these proceedings

Introduction

In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.

Keywords

breast cancer carcinogenesis hormones liver steroids

Editors and affiliations

  • Jonathan J. Li
    • 1
  • Satyabrata Nandi
    • 2
  • Sara Antonia Li
    • 1
  1. 1.Hormonal Carcinogenesis Laboratory and Department of Pharmaceutical Sciences, College of PharmacyWashington State UniversityPullmanUSA
  2. 2.Department of Molecular and Cell Biology, Cancer Research LaboratoryUniversity of CaliforniaBerkeleyUSA

Bibliographic information