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Pathophysiology of the Muscle Phase

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Trichinella and Trichinosis

Abstract

Since Paget (1866) discovered Trichinella spiralis muscle larvae during a human autopsy, numerous studies have focused on myopathophysiology in trichinosis. From these studies, it soon became apparent that some of the more outstanding clinical manifestations and the primary causes of mortality in this disease were related to parasitism of striated skeletal muscle and invasion of the myocardium (see Chapter 11). Evidence was also provided establishing the intracellular existence of the muscle larva and revealing that the parasite induced many dramatic alterations in the chemical and physical nature of the host cell. Many of the myopath- ophysiological changes in trichinosis result from the process by which the parasite establishes with the host striated myofiber one of the most intimate and complex host-helminth relationships in nature. This chapter addresses pathophysiology of the muscle phase with emphasis on the roles played by these lesions in the evolution of the aforementioned relationship.

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References

  • Backwinkle, K.D., and Themann, H., 1972, Elektronmikroscopische Untersuchungen über die Pathomorphologie der Trichinellose, Beitr. Pathol. 146: 259–271.

    Google Scholar 

  • Beckett, E.B., 1961, Some histochemical changes in the protein of mouse skeletal muscle fibers infected by Trichinella spiralis, Ann. Trop. Med. Parasitol. 55: 419–426.

    PubMed  CAS  Google Scholar 

  • Beckett, E.B., and Boothroyd, B., 1961, Some observations on the mature larva of the nematode Trichinella spiralis, Ann. Trop. Med. Parasitol. 55: 116–124.

    PubMed  CAS  Google Scholar 

  • Beckett, E.B., and Boothroyd, B., 1962, The histochemistry and electron microscopy of glycogen in the larva of Trichinella spiralis and its environment, Ann. Trop. Med. Parasitol. 56: 264–273.

    CAS  Google Scholar 

  • Bischoff, T.L.W., 1840, Ein Fall von Trichina spiralis, Heidelh. Med. Ann. 6: 232–238.

    Google Scholar 

  • Boczon, K., 1967, Some data on bioenergetics of the larvae of Trichinella spiralis, Bull. Soc. Amis Sci. Lett. Poznan Ser. D 8: 165–170.

    Google Scholar 

  • Boczon, K., Michejda, J.W., and Hryniewiecka, L., 1967, Changes in bioenergetics of mitochondria and on lactate-N AD-oxidoreductase activity in rat skeletal muscle during experimental trichinosis, Proceedings of the 4th Meeting of the Federation of European Biochemical Societies, Oslo, Sweden, pp. 128.

    Google Scholar 

  • Borgers, M., DeNollen, S., and Thone, F., 1975, The development of alkaline phosphatase in trichinous muscle, Histochemistry 43: 257–267.

    Article  PubMed  CAS  Google Scholar 

  • Bourne, G.H., 1973, The Structure and Function of Muscle, Vols. I–IV, Academic Press, New York.

    Google Scholar 

  • Bruce, R.G., 1970a, The structure and development of the capsule of Trichinella spiralis, J. Parasitol. 56: 38–39.

    Article  Google Scholar 

  • Bruce, R.G., 1970b, The structure and composition of the capsule of Trichinella spiralis in host muscle, Parasitology 60: 223–227.

    Article  PubMed  CAS  Google Scholar 

  • Bullock, W. L., 1953, Phosphatases in experimental Trichinella spiralis infections in the rat, Exp. Parasitol. 12: 150–162.

    Article  Google Scholar 

  • Bullock, W.L., and Gangi, D.P., 1950, The distribution of alkaline glycerophosphatase in the muscle of rats infected with Trichinella spiralis, J. Parasitol. 36:Suppl. 30.

    Google Scholar 

  • Casey, M.A., and Harley, J.P., 1978, Trichinella spiralis: Skeletal muscle membrane potentials in infected and uninfected mice, Exp. Parasitol. 44: 66–71.

    Article  PubMed  CAS  Google Scholar 

  • Cohnheim, J., 1865, Todtliche Trichinose mit parenchymatoser Degeneration von Leber, Herz und Nieren, Virchows Arch. Pathol. Anat. 33: 447–451.

    Google Scholar 

  • Despommier, D.D., 1975, Adaptive changes in muscle fibers infected with Trichinella spiralis, Am. J. Pathol. 78: 477–496.

    PubMed  CAS  Google Scholar 

  • Despommier, D.D., 1976, Musculature, in: Ecological Aspects of Parasitology (C.R. Kennedy, ed.), North-Holland, Amsterdam, pp. 269–285.

    Google Scholar 

  • Despommier, D.D., Aron, L., and Turgeon, L., 1975, Trichinella spiralis: Growth of the intracellular (muscle) larva, Exp. Parasitol. 37: 108–116.

    Article  PubMed  CAS  Google Scholar 

  • Drachman, D.A., and Tunchay, T.O., 1965, The remote myopathy of trichinosis, Neurology 15: 1127–1135.

    PubMed  CAS  Google Scholar 

  • Dunlap, G.L., and Weiler, C.V., 1933, Pathogenesis of trichinous myocarditis, Proc. Soc. Exp. Biol. Med. 30: 1261–1262.

    Google Scholar 

  • Durante, G., 1902, Anatomie pathologique des muscles, in: Manuel d’Histologie Pathologique (F. Cornil and G. Ranvier, eds.), Masson, Paris, pp. 18–44.

    Google Scholar 

  • Edwards, J.L., and Hood, C.I., 1962, Studies on the pathogenesis of cardiac and cerebral lesions of experimental trichinosis in rabbits, Am. J. Pathol. 40: 711–717.

    PubMed  CAS  Google Scholar 

  • Ehrhardt, P., 1896, Zur Kenntniss der Muskelveränderungen bei der Trichinose des Menschen, Beitr. Pathol. Anat. 20: 1–42.

    Google Scholar 

  • Farris, K., and Harley, J.P., 1977, Trichinella spiralis: Alteration of gastrocnemius muscle kinetics in the mouse, Exp. Parasitol. 41: 17–30.

    Article  PubMed  CAS  Google Scholar 

  • Fasske, E., and Themann, H., 1961, Elektronmicroskopische Befunde an der Muskelfaser nach Trichinbefall, Virchows Arch. Pathol. Anat. 334: 459–474.

    Article  CAS  Google Scholar 

  • Fielder, A., 1864, Uber die Kernwucherung in der Muskeln bei der Trichinenkrankenheit, Virchows Arch. Pathol. Anat. 30: 461–468.

    Google Scholar 

  • Flury, F., 1913, Beitrage zur Chemie und Toxokologie der Trichinin, Arch. Exp. Pathol. Pharmakol. 53: 164–213.

    Google Scholar 

  • Frothingham, C., Jr., 1906, A contribution to the knowledge of the lesions caused by Trichina spiralis, J. Med. Res. 15: 483–490.

    PubMed  CAS  Google Scholar 

  • Gabryel, P., and Gustowska, L., 1967, Veränderungen der quergestreiften Muskelfasern im frühen Stadium einer Trichinal spiralis Infektion, Gegenbauers Morph. Jahrb. 111: 174–180.

    CAS  Google Scholar 

  • Garbulinski, T., Kozar, Z., Bubien, Z., Debowy, J., and Biblinski, E., 1965, 32P-Incorpo-ration into energetic phosphates of the heart and skeletal muscles in rats infected with Trichinella spiralis, Acta Parasitol. Pol. 13: 275–281.

    CAS  Google Scholar 

  • Gould, S.E., 1945, Pathology, in: Trichinosis (S.E. Gould, ed.). Charles C. Thomas, Springfield, Illinois, pp. 73–132.

    Google Scholar 

  • Gould, S.E., 1970, Anatomic pathology, in: Trichinosis in Man and Animals (S.E. Gould, ed.), Charles C. Thomas, Springfield, Illinois, pp. 147–189.

    Google Scholar 

  • Graham, J.Y., 1897, Beiträge zur Naturgeschichte der Trichina spiralis, Arch. Mikrosk. Anat. 50: 219–275.

    Article  Google Scholar 

  • Hankes, L.V., and Stoner, R.D., 1958, Incorporation of DL-tyrosine-2-C-14 and DL-tryptophan-2-C-14 by encysted Trichinella spiralis larvae, Exp. Parasitol. 7: 82–89.

    Article  Google Scholar 

  • Hemmert-Halswick, A., and Bugge, G., 1934, Trichinen und Trichinose, Ergebn. Allg. Pathol. 28: 313–319.

    Google Scholar 

  • Horlick, S.S., and Bicknell, R.E., 1929, Trichiniasis with wide-spread infestation of many tissues, N. Engl. J. Med. 201: 816–819.

    Article  Google Scholar 

  • Howard, W.T., Jr., 1899, Report of a fatal case of trichinosis without eosinophilia but with large numbers of eosinophilic cells in the muscle lesions; with remarks on the origin of eosinophilic cells in trichinosis, Philadelphia Med. J. 4: 1085–1087.

    Google Scholar 

  • Hryniewiecka, L., Boczon, K., and Michejda, J.W., 1970, Trichinella spiralis: Enzymes reducing and oxidizing cytochrome c in rat muscle, Exp. Parasitol. 28: 544–550.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, W.L., and Harley, J.P., 1977, Trichinella spiralis: Taxes of first stage migratory larvae. Exp. Parasitol. 42: 363–373.

    Article  PubMed  CAS  Google Scholar 

  • Karpiak, S.E., Kozar, Z., and Krzyanowski, M., 1963, Changes in the metabolism of the skeletal muscles of guinea pigs caused by the invasion of Trichinella spiralis. I. Influence of the invasion on the carbohydrate metabolism of muscles, Wiad. Parazytol. 9: 435–446.

    CAS  Google Scholar 

  • Knorr, H., 1912, Bietrag zur Kenntnis der Trichinellen Krankheit des Menschen, Dtsch. Arch. Klin. Med. 108: 137–159.

    Google Scholar 

  • Kozar, Z., Karpiak, S.E., and Krzyzanowski, M., 1965, Changes in the metabolism of the skeletal muscles of guinea pigs caused by the invasion of Trichinella spiralis. II. Effect of invasion on the metabolism of organic acids, Acta Parasitol. Pol. 13: 271–274.

    Google Scholar 

  • Kozar, Z., Zarzycki, J., Seniuta, R., and Martynowicz, T., 1967, Histochemical study of drug effects on mice infected with Trichinella spiralis, Exp. Parasitol. 21: 177–185.

    Article  Google Scholar 

  • Langerhans, R., 1892, Ueber regressive Veränderungen der Trichinen und ihre Kapseln, Virchows Arch. Pathol. Anat. 130: 205–216.

    Article  Google Scholar 

  • Leuckart, R., 1860, Untersuchungen über Trichina spiralis, Leipzig, Winter, pp. 57.

    Google Scholar 

  • Lewis, J.H., 1928a, Studien über den Mechanismus der Trichinelleninfektion. II. Der Einfluss des Glykogens auf die Muskelinvasion, Zentralbl. Bakteriol. 107: 114–126.

    CAS  Google Scholar 

  • Lewis, J.H., 1928b, Influence of glycogen on the infection of muscle with trichinae, Trans. Chicago Pathol. Soc. 13: 12–15.

    Google Scholar 

  • Loeschke, H., 1927, Vorstellungen über das Wesen von Hyalin und Amyloid auf Grund von serologischen Versuchen, Beitr. Pathol. Anat. 77: 231–239.

    Google Scholar 

  • Maier, D.M., and Zaiman, H., 1966, The development of lysosomes in rat skeletal muscle in trichinous myositis, J. Histochem. Cytochem. 14: 396–400.

    Article  Google Scholar 

  • Maier, D.M., Zaiman, H., and Howard, R., 1962, Histochemical changes in muscle degeneration, Lab. Invest. 11: 667 (abstract).

    Google Scholar 

  • McCoy, O.R., Downing, V.F., and van Voorhis, S.N., 1941, The penetration of radioactive phosphorus into encysted Trichinella larvae, J. Parasitol. 27: 53–58.

    Article  Google Scholar 

  • Michejda, J.W., and Boczon, K., 1972, Changes in bioenergetics of skeletal muscle mitochondria during experimental trichinosis in rats, Exp. Parasitol. 3: 161–171.

    Article  Google Scholar 

  • Nevinny, H., 1927, Uber die Veränderungen der Skelettmuskulatur bei Trichinose, Virchows Arch. Pathol. Anal. 266: 185–238.

    Article  Google Scholar 

  • Nicolesco, S., Onicesco, D., Gavat, V., and Simionesco, V., 1962, A propos de la signification de certaines lesions nerveuses déterminées par les parasites animaux a localisation musculaire, Acta Morphol. Acad. Sci. Hung. 11: 257–266.

    PubMed  CAS  Google Scholar 

  • Ochoa, J., and Pallis, C., 1980, Trichinella thrives in both oxidative and glycolytic human muscle fibers, J. Neurol. Neurosurg. Psychiatry 43: 281–282.

    Article  PubMed  CAS  Google Scholar 

  • Ogielski, L., 1949, Reaction of the vascular vessels against invasion of the larvae of Trichinella spiralis, Zool. Pol. 5: 35–42.

    Google Scholar 

  • Paget, J., 1866, On the discovery of trichina, Lancet 1: 269–270.

    Article  Google Scholar 

  • Purkerson, J., and Despommier, D., 1974, Fine structure of the muscle phase of Trichinella spiralis in the mouse, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 7–23.

    Google Scholar 

  • Read, C.P., 1970, Chemical pathology, in: Trichinosis in Man and Animals (S.E. Gould, ed.), Charles C. Thomas, Springfield, Illinois, pp. 91–101.

    Google Scholar 

  • Ribas-Mujal, D., 1971, Trichinosis, in: Pathology of Protozoal and Helminthic Diseases, Williams and Wilkins, Baltimore, pp. 677–710.

    Google Scholar 

  • Ribas-Mujal, D., and Rivera-Pomar, J.M., 1968, Biological significance of the early structural alterations in skeletal muscle fibers infected by Trichinella spiralis, Virchows Arch. Pathol. Anat. 345: 154–168.

    Article  CAS  Google Scholar 

  • Ritterson, A.L., 1966, Nature of the cyst of Trichinella spiralis, J. Parasitol. 52: 157–161.

    Article  PubMed  CAS  Google Scholar 

  • Rogers, W.P., 1942, The metabolism of trichinosed rats during the early phase of the disease, J. Helminthol. 20: 139–158.

    Article  CAS  Google Scholar 

  • Schanzel, H., and Holman, J., 1966, Lokalisation der alkalischen Phosphatase in der Trichinella befallenden Muskulatur, Angew. Parasitol. 7: 252–259.

    Google Scholar 

  • Seniuta, R., 1971, Histochemical investigations of the activity of some phosphates in skeletal muscles of mice under the influence of infection with Trichinella spiralis, Fol. Histochem. Cytochem. 9: 95–116.

    CAS  Google Scholar 

  • Staubli, C., 1905a, Klinische und experimentelle Untersuchengen über Trichinosis, Verhandl. Kongr. Inn. Med. 22: 353–362.

    Google Scholar 

  • Staubli, C., 1905b, Klinische und experimetelle Untersuchungen über Trichinose und über die Eosinophilie in Allgemeinen, Virchows Arch. Pathol. Anat. Physiol. 85: 286–341.

    Google Scholar 

  • Staubli, C., 1909, Trichinosis, J.Y. Bergmann, Wiesbaden, 295 pp.

    Google Scholar 

  • Stewart, G.L., 1973, Studies on chemical pathology in trichinosis, Doctoral thesis, Rice University, Houston, Texas, 85 pp.

    Google Scholar 

  • Stewart, G.L., 1976, Studies on biochemical pathology in trichinosis. II. Changes in liver and muscle glycogen and some blood chemical parameters in mice, Rice Univ. Stud. 62: 211–223.

    Google Scholar 

  • Stewart, G.L., and Charniga, L.M., 1980, Distribution of Trichinella spiralis in muscles of the mouse, J. Parasitol. 66: 688–689.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., and Giannini, S., 1982, Intracellular parasites of striated muscle: A review, Exp. Parasitol. 53: 406–447.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., and Read, C.P., 1972a, Ribonucleic acid metabolism in mouse trichinosis, J. Parasitol. 58: 252–256.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., and Read, C.P., 1972b, Some aspects of cyst synthesis in mouse trichinosis, J. Parasitol. 58: 1061–1064.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., and Read, C.P., 1973a, Deoxyribonucleic acid metabolism in mouse trichinosis, J. Parasital. 59: 264–267.

    Article  CAS  Google Scholar 

  • Stewart, G.L., and Read, C.P., 1973b, Changes in RNA in mouse trichinosis, J. Parasitol. 59: 997–1005.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., and Read, C.P., 1974. Studies on biochemical pathology in trichinosis. I. Changes in myoglobin, free creatine, phosphocreatine and two protein fractions of mouse diaphragm muscle, J. Parasitol. 60: 996–1000.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, G.L., Fisher, F.M., Jr., Ribelles, E., Chiapetta, V., and LaBrum, R., 1978, Trichinella spiralis: Alterations of blood chemistry in the mouse, Exp. Parasitol. 45: 287–297.

    Article  PubMed  CAS  Google Scholar 

  • Stoner, R.D., and Hankes, L.V., 1955, Incorporation of C14 labeled amino acids by Trichinella spiralis, Exp. Parasitol. 4: 435–444.

    Article  PubMed  CAS  Google Scholar 

  • Stoyanov, D.P., and Nenov, St. D. 1965, Some histochemical changes in tissues of guinea pigs infected with Trichinella spiralis, Med. Parazytol. 34: 392–396.

    Google Scholar 

  • Teppema, J.S., Robinson, J.E., and Ruitenberg, E.J., 1973, Ultrastructural aspects of capsule formation in Trichinella spiralis infection in the rat, Parasitology 66: 291–296.

    Article  PubMed  CAS  Google Scholar 

  • Terry, L.L., and Work, J.L., 1940, Trichinosis of the myocardium: Report of a case with autopsy findings, Am. Heart J. 19: 478–485.

    Article  Google Scholar 

  • Virchow, R., 1860a, Uber Trichina spiralis, Virchows Arch. Pathol. Anat. 18: 330–346.

    Google Scholar 

  • Virchow, R., 1860b, Vorläufige Nachricht über neue trichinen Fütterungen, Virchows Arch. Pathol Anat. 18: 535–536.

    Google Scholar 

  • Wehrmann, O., 1927, Beitrag zur pathologischen Anatomie der Trichinose des Menschen, Virchows Arch. Pathol. Anat. 263: 584–589.

    Article  Google Scholar 

  • Weller, C.V., and Shaw, M., 1932, Myocardial failure due to trichinosis, Trans. Assoc. Am. Physicians 47: 31–46.

    Google Scholar 

  • Zarzycki, J., 1956, Histologic investigations on the glycogen content in striated muscle infected with trichinellae, Med. Weter. 12: 328–332.

    Google Scholar 

  • Zarzycki, J., 1962, Histochemical investigations on distribution of nucleic acids and inorganic salts in muscle tissue at the infection with Trichinella spiralis in: Trichinellosis, Proceedings of the 1st International Conference on Trichinellosis (Z. Kozar, ed.), Polish Scientific Publications, Warsaw, pp. 302–305.

    Google Scholar 

  • Zarzycki, J., 1963, Studies on distribution and activity of succinic dehydrogenase in muscle tissue during infection with Trichinellae, Wiad. Parazytol. 9: 459–464.

    Google Scholar 

  • Zoller, H., 1927, Uber Herzmuskelentzündung im Verlauf der Trichinose, Virchows Arch. Pathol. Anat. 265: 430–443.

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Parasitology, Department of Biology, The University of Texas, Arlington, Texas, 76019, USA

    George L. Stewart

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  1. George L. Stewart
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  1. Merck Institute for Therapeutic Research, Rahway, New Jersey, USA

    William C. Campbell

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© 1983 Plenum Press, New York

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Stewart, G.L. (1983). Pathophysiology of the Muscle Phase. In: Campbell, W.C. (eds) Trichinella and Trichinosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3578-8_7

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  • DOI: https://doi.org/10.1007/978-1-4613-3578-8_7

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