Abstract
The utility of clearance (CL) as the parameter to relate rate of elimination to measured drug concentration is now well established in pharmacokinetics. The concept of clearance was first proposed by Möller et al. (1) to characterize the handling of urea by the kidney, and subsequently applied to quantitate the removal of substances by the liver, gastrointestinal tract and other eliminating organs. Today, clearance measurements are used to assess organ function, to predict steady-state concentrations following constant rate regimens, to predict the degree of hepatic first-pass loss of orally administered drug, and to assess the extent of drug absorption (2,3). The application of clearance concepts in pharmacokinetics has come with the measurement of concentrations of drug and metabolites in plasma and blood.
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© 1984 Plenum Press, New York
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Rowland, M. (1984). Clearance — Models, Validation and Implications. In: Benet, L.Z., Levy, G., Ferraiolo, B.L. (eds) Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2799-8_13
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DOI: https://doi.org/10.1007/978-1-4613-2799-8_13
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