Summary
Epidemiologic studies of Epstein-Barr Virus (EBV)-associated malignancies continue to demonstrate the interrelationship of multiple etiologic factors, thereby allowing several opportunities for intervention with the disease process. For the two malignancies most closely linked with EBV, Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC), the risk factors are more readily identified in high-incidence areas than in low-incidence areas. The report of an apparent decline in BL incidence in Africa is in contrast with a reported increase in incidence among young white males in the United States. The search for etiologic factors in BL, in addition to EBV and malaria, is currently focusing on retroviruses. For NPC, evidence continues to support the major roles of genetics and salted fish in southern Chinese, but other etiologic factors appear to be important in non-Chinese. In areas of low incidence for BL and NPC, less homogeneous patterns are seen suggesting the inclusion of unrelated cases. Precise definition of study groups may be aided by new laboratory assays. The further development and utilization of cancer registry data throughout the world will also increase our knowledge of these diseases.
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References
ARMSTRONG, R.W., ARMSTRONG, M.J., YU, M.C., AND HENDERSON, B.E., Salted fish and inhalants as risk factors for nasopharyngeal carcinoma. Cancer, 43, 2967–2970 (1983)
BALE, S., BALE, A.E., AND LEVINE, P.H., The “Family Study” approach to investigating the role of genetic factors in nasopharyngeal carcinoma (this volume).
BERARD, C.W., O’CONOR, G.T., THOMAS, L.B., and TORLONI, H., Histopathological Definition of Burkitt’s Tumor, World Health Organization, , New York (1969).
BIGGAR, R.J., NKRUMAH, F.K., NEEQUAYE, J., and LEVINE, P.H., Changes in presenting tumor site of Burkitt’s lymphoma in Ghana, West Africa, 1975–1978. Br. J. Cancer, 46, 632–636 (1981).
BURKITT, D., A lymphoma syndrome in African children. Ann. Royal Coll. Surg. Eng., . 30, 211–219 (1962).
FRAUMENI, J.F., JR., AND MASON, T.J., Cancer mortality among Chinese Americans, 1950–1969. JNCI, 52, 659–665 (1974).
HO., J.H.C., Nasopharyngeal carcinoma (NPC). In: G. Klein, S. Weinhouse, and A. Haddow (eds.), Advances in Cancer Research, pp. 57–92, Academic Press, New York (1972).
HUANG, D.P., SAW, D., TEOH, T.B., AND HO, J.H.C., Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish. In: G. de-The, and Y. Ito (eds.), Nasopharyngeal Carcinoma: Etiology and Control, pp. 315–3Z8, International Agency for Research in Cancer, Lyon (1978).
ITO, Y., KISHISHITA, M., MORIGAKI, T., YANASE, S., and HIRAYAMA, T., Induction and intervention of Epstein-Barr virus expression in human lymphoblastoid cell lines: a simulation model for study of cause and prevention of nasopharyngeal carcinoma and Burkitt’s lymphoma. In: E. Grundmann, G.R.F. Krueger, and D.V. Ablashi (eds.), Nasopharyngeal Carcinoma, pp. 255–262, Gustav Fischer Verlag, Stuttgart/New York(1981).
JUDSON, S.C., HENLE, W., and HENLE, G., A cluster of Epstein-Barr virus-associated American Burkitt’s lymphomas. N. Engl. J. Med., 297, 464–468 (1977).
KLEIN, G., Studies on the Epstein-Barr virus genome and the EBV-determined nuclear antigen in human malignant disease in tumor viruses. Cold Spring Harbor Symp. Quant. Biol., 39, 783–796 (1974).
Lenoir, G., O’conor, G.T., And Olweny, C. (eds.), Burkitt’s Lymphoma: A Human Tumor Model, International Agency for Research on Cancer, Lyon (1985).
Levine, P.H., And Connelly, R.R., Epidemiology of nasopharyngeal cancer. In: R.E. Wittes (ed.), Head and Neck Cancer, pp. 13–34, John Wiley and Sons, Ltd., Sussex, England (1985).
Levine, P.H., Connelly, R.R., And Mckay, W.F., The influence of residence, race, and place of birth on the incidence of nasopharyngeal carcinoma. In: U. Prasad, D.V. Ablashi, P.H., Levine, and G.R. Pearson (eds.), Nasopharyngeal Carcinoma: Current Concepts, pp. 143–156, University of Malaya Press, Kuala Lumpur (1983).
Levine, P.H., Connelly, R.R., And Mckay, W.F., Burkitt’s lymphoma in the United States: cases reported to the American Burkitt Lymphoma Registry compared with population-based incidence and mortality data. In: G.T. O’Conor (ed.), Burkitt’s Lymphoma: A Human Cancer Model, International Agency for Research on Cancer, Lyon (in press).
Levine, P.H., Connelly, R.R., And Mckay, F.W., Recent findings in nasopharyngeal cancer in the United States, (submitted).
Levine, P.H., Kamaraju, L.S., Connelly, R.R., Berard, C.W., Dorfman, R.F., Magrath, I., And Easton, J.M., The American Burkitt’s lymphoma registry: Eight years experience. Cancer, 49, 1016–1022 (1982).
Levine, P.H., O’conor, G.T., And Berard, C.W., Antibodies to Epstein-Barr virus (EBV) in American patients with Burkitt’s lymphoma. Cancer, 30, 610–615 (1972).
Levine, P.H., Sandler, S.G., Komp, D.M., O’conor, G.T., And O’connor, D.M., Simultaneous occurrence of “American Burkitt’s Lymphoma” in neighbors. N. Engl. J. Med., 288, 562–563 (1973).
Magrath, I., Clinical and pathobiological features of Burkitt’s lymphoma and their relevance to treatment (this volume).
Miller, R.W., Genetic and familial factors. In: P. Calabresi, P.S. Schein, and S.A. Rosenberg (eds.), Basic Principles and Clinical Management of Cancer, Macmillan Publishing Company, New York (in press).
Pike, M.C., Williams, E.H., And Wright, B.H., Burkitt’s tumour in the West Nile District of Uganda, 1961–5. Br. J. Med., 2, 395–399 (1967).
Pike, M.C., And Morrow, R.H., Some epidemiological problems with “EBV + Malaria gives BL”-A review. In: P.M. Biggs, G. de-The, and L.N. Payne (eds.). Oncogenesis and Herpesviruses, pp. 349–350, International Agency for Research on Cancer, Lyon (1972).
Raab-Traub, N., Huang, D., Yang, C.S., And Pearson, G., Ebv Dna content and expression in nasopharyngeal carcinoma (this volume).
Saxinger, W., Blattner, W.A., Levine, P.H., Clark, J., Biggar, R., Hoh, M.W., Moghissi, J., Mourali, N., Nkrumah, F.K., Wilson, P.J.L., Jacobson, R., Crookes, R., Strong, M., Ansari, A.A., And Gallo, R.C., Human T-cell leukemia virus (HTLV-1) antibodies in Africa. Science, 225, 1473–1476 (1984).
Saxinger, W.C., Levine, P.H., Dean, A.G., De-The, G., Sarngadharan, M.G., And Gallo, R.C., Evidence for exposure to the HTLV-III in Uganda prior to 1973 (submitted).
Shanmugaratnam, K., Nasopharynx. In: D. Schottenfeld, and J.F. Fraumeni, Jr. (eds.), Cancer Epidemiology and Prevention, pp. 536–553, W.B. Saunders Co., Philadelphia (1982).
Simons, M.J., Genetic aspects of EBV-associated malignancies (this volume).
Simons, M.J., And Shanmugaratnam, K. (eds.), The Biology of Nasopharyngeal Carcinoma, UICC Technical Report Series, Hans Huber Publishers, Berne (1982).
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© 1985 Martinus Nijhoff Publishing, Boston
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Levine, P.H. (1985). The Epidemiology of Epstein-Barr Virus-Associated Malignancies. In: Levine, P.H., Ablashi, D.V., Pearson, G.R., Kottaridis, S.D. (eds) Epstein-Barr Virus and Associated Diseases. Developments in Medical Virology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2625-0_8
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DOI: https://doi.org/10.1007/978-1-4613-2625-0_8
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