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Epstein-Barr Virus and Associated Diseases

Proceedings of the First International Symposium on Epstein-Barr Virus-Associated Malignant Diseases (Loutraki, Greece—September 24–28, 1984)

  • Editors
  • P. H. Levine
  • D. V. Ablashi
  • G. R. Pearson
  • S. D. Kottaridis

Part of the Developments in Medical Virology book series (DIMV, volume 1)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Immunodeficiency Diseases

  3. EBV-Associated Malignancies

    1. Front Matter
      Pages 79-79
    2. Malcolm J. Simons
      Pages 90-105
    3. Anne P. Lanier, Sarala Krishnamurthy, Susan E. Clift, Kathy T. Kline, Georg W. Bornkamm, Werner Henle et al.
      Pages 145-150
    4. M. Yadav, N. Malliha, A. W. Norhanom, U. Prasad
      Pages 180-192
  4. Molecular Biology of EBV

    1. Front Matter
      Pages 219-219
    2. Elliott Kieff, Kevin Hennessy, Timothy Dambaugh, Takumi Matsuo, Sue Fennewald, Mark Heller et al.
      Pages 221-247
    3. M. Bodescot, B. Chambraud, M. Perricaudet
      Pages 256-266
    4. N. Balachandran, L. M. Hutt-Fletcher
      Pages 289-298
    5. P. J. Farrell, J. Dyson, P. Tuffnell, M. Biggin, T. Gibson, A. Bankier et al.
      Pages 299-306
    6. Jen-Yang Chen, R. Palmer Beasley, Chia-Siang Chien, Czau-Siung Yang
      Pages 307-310
    7. H. Wolf, S. Gu, M. Haus, U. Leser
      Pages 311-316
  5. Mechanisms of EBV Transformation

    1. Front Matter
      Pages 317-317
    2. Ronald Glaser
      Pages 319-333
    3. Beverly E. Griffin, David King, Loraine Karran
      Pages 355-361
    4. N. Raab-Traub, D. Huang, C. S. Yang, G. Pearson
      Pages 362-372
    5. David J. Volsky, Barbara Volsky, Mona Hedeskog, Faruk Sinangil, Thomas G. Gross
      Pages 373-382
    6. Yohei Ito, Harukuni Tokuda, Hajime Ohigashi, Koichi Koshimizu, Yi Zeng
      Pages 383-391
    7. D. V. Ablashi, J. Whitman, J. Dahlberg, G. Armstrong, J. Rhim
      Pages 392-401
  6. EBV Proteins

    1. Front Matter
      Pages 409-409
    2. G. Milman, D. K. Ades, M.-S. Cho, S. C. Hartman, G. S. Hayward, A. L. Scott et al.
      Pages 426-435
    3. J. Dillner, L. Eliasson, L. Sternås, B. Kallin, G. Klein, R. A. Lerner
      Pages 446-455
    4. J. Luka, T. Kreofsky, T. C. Spelsberg, G. R. Pearson, K. Hennessey, E. Kieff
      Pages 456-465
    5. Ann Boyd, Jay Stoerker, Jane Holliday, Ronald Glaser
      Pages 466-476
    6. Masamichi Kishishita, Yohei Ito, Janos Luka, Gary R. Pearson
      Pages 477-484

About this book

Introduction

It has been slightly more than two decades since the Epstein-Barr virus (EBV) was discovered by Prof. M.A. Epstein and his colleagues at the University of Bristol in their search for the causative agent of Burkitt's lymphoma. For several years EBV was a "virus in search of a disease." The first documentation that EBV was pathogenic for humans was in 1969 when Drs. Gertrude and Werner Henle identified it as the causative agent for infectious mononucleosis. Seroepidemiologic and biochemical studies subsequently linked EBV to Burkitt's lymphoma (BL), nasopharyngeal carcinoma (NPC), and more recently to the X-linked lymphoproliferative syndrome. With its widespread pattern of infection and a predilection for producing clinical signs and symptoms in only certain individuals, EBV has provided a model for many other candidate oncogenic viruses, including papilloma viruses, herpes simplex, and HTLV/LAV. In 1975, an international workshop was sponsored by the National Cancer Institute to address the problem of EBV production, thus facilitating basic research on the virus. This proved to be the last international meeting on EBV for almost a decade. In the past, progress in both clinical and basic research on EBV has been presented in two types of international meetings, the international herpesvirus workshops devoted primarily to basic research on both human and animal herpesviruses, and the international symposia on NPC, in which EBV-related studies were interspersed with clinical, epidemiologic and other etiologic aspects of this important human neoplasm.

Keywords

antibody antigen cancer cell documentation immunodeficiency immunology immunosuppression infection infectious lymphoma molecular biology neoplasm research virus

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