Abstract
Skin biopsies from 150 patients with cutaneous lymphoma, premalignant or “pseudolymphomatous” conditions and benign dermatoses were examined by immunoenzymatic staining of frozen sections with a panel of monoclonal antibodies against lymphocytes, macrophages and accessory cells. Two patterns of infiltration were identified. In one of these T cells associated with Langerhans cells and HLA-DR-positive macrophages of dendritic morphology, were seen. In the other B cell follicles were present in addition to the above type of infiltrate. The latter pattern was restricted to patch tests biopsies, cutaneous lymphocytomas, and malignant lymphomas of B-cell origin.
It is concluded that lymphocytic skin infiltrates are divisible into different patterns of immunological reactions similar to those seen in lymphoid organs.
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Ralfkiaer, E., Hou-Jensen, K., Mason, D.Y., Stein, H., Wantzin, G.L., Thomsen, K. (1985). Benign and Malignant Lymphocytic Skin Infiltrates Immunological Patterns Recognized by Immunohistochemical Staining with Monoclonal Antibodies. In: Klaus, G.G.B. (eds) Microenvironments in the Lymphoid System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2463-8_125
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DOI: https://doi.org/10.1007/978-1-4613-2463-8_125
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