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Molecular Mechanisms in Genetic Stability and Change: The Role of Deoxyribonucleotide Pool Balance

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Genetic Consequences of Nucleotide Pool Imbalance

Part of the book series: Basic Life Sciences ((BLSC,volume 31))

Abstract

For both theoretical and practical reasons, elucidation of the dialectical processes of genetic stability and change is one of the central problems of biology. The molecular basis of evolution resides in the intimately associated mechanisms of heredity and mutagenesis, which together have led gradually to the accumulation of a vast store of genetic variation within gene pools. Although the actual course of evolution is mediated by natural selection, in the absence of variation, selection can do nothing [7]. Heredity is a manifestation of the stability of genes from one generation to the next. It is necessary for the formation of normal progeny, and for the integrity and longevity of species. Genetic variation is a manifestation of the instability of genes, and of the ‘fluidity’ of the genome. It is responsible, ultimately, for the origin of species, but more immediately, for a substantial number of serious human diseases, including cancer.

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Authors and Affiliations

  1. Department of Biology, York University, Toronto, Ontario, M3J IP3, Canada

    Robert H. Haynes

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  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

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© 1985 Plenum Press, New York

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Haynes, R.H. (1985). Molecular Mechanisms in Genetic Stability and Change: The Role of Deoxyribonucleotide Pool Balance. In: de Serres, F.J. (eds) Genetic Consequences of Nucleotide Pool Imbalance. Basic Life Sciences, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2449-2_1

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  • DOI: https://doi.org/10.1007/978-1-4613-2449-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9488-7

  • Online ISBN: 978-1-4613-2449-2

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