Genetic Consequences of Nucleotide Pool Imbalance

  • Frederick J. de Serres

Part of the Basic Life Sciences book series (BLSC, volume 31)

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

  3. Nucleotide Metabolism

  4. DNA Replication Errors Caused by Nucelotide Imbalance

  5. Genetic Consequences of Nucleotide Pool Imbalances

    1. Bernard A. Kunz
      Pages 189-209
    2. Wolfgang Sadée, Binh Trong Nguyen
      Pages 233-240
    3. Takeshi Seno, Dai Ayusawa, Kimiko Shimizu, Hideki Koyama, Keiichi Takeshi, Tada-aki Hori
      Pages 241-263
    4. David I. Hoar, Leo S. Dimnik
      Pages 265-282
    5. Mark Meuth, Otelinda Gonçalves, Marie Trudel
      Pages 297-312
    6. A. R. Peterson, P. V. Danenberg, L. L. V. Ibric, H. Peterson
      Pages 313-334

About this book

Introduction

This book is concerned with the genetic consequences of nu­ cleotide pool imbalance. There are a number of ways in which this state can be achieved and the majority of papers in this volume de­ scribe the effects of nucleotide pool imbalance on DNA replication and repair, and the induction of gene mutations in various organisms. This book grew out of a Conference on "Genetic Consequences of Nu­ cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983. The Organizing Com­ mittee consisted of Drs. Diana Anderson (BIBRA), Robert Haynes (York University), Bernard Kunz (NIEHS), Barry Glickman (NIEHS), and Frederick J. de Serres (NIEHS), Chairman. The meeting was org- ized by the staff of the Office of the Associate Director for Genetics and was financed solely by the National Institute of Environmental Health Sciences. Frederick J. de Serres, Ph.D. Associate Director for Genetics v CONTENTS SECTION I. INTRODUCTION Molecular Mechanisms in Genetic Stability and Change: 1 The Role of Deoxyribonucleotide Pool Balance •••••• Robert H. Haynes SECTION II. NUCLEOTIDE METABOLISM 25 Metabolic Effects of Poly(ADP-ribose) Inhibitors •••••••• Kathryn M. Milam and James E. Cleaver Ribonucleotide Reductase and Deoxyribonucleotide 33 POQ 1 s ............................................ . Peter Reichard 47 Enzymatic Channeling of DNA Precursors •••••••••••••••••• Christopher K. Mathews A Possible Secondary Role for Thymine-Containing DNA 67 Precursors ....................................... . Robert J. Melamede and Susan S. Wallace Multiple Mechanisms of Adenosine Toxicity in an Adenosine Sensitive Mutant of Baby Hamster 103 Kidney (BHK) Cells ............................... .

Keywords

DNA Nucleotide enzyme gene genetics metabolism molecular mechanisms mutation replication

Editors and affiliations

  • Frederick J. de Serres
    • 1
  1. 1.National Institute of Environmental Health SciencesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-2449-2
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9488-7
  • Online ISBN 978-1-4613-2449-2
  • About this book