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Pathogenesis of Perivenous and Demyelinating Encephalomyelitis and Its Relevance for Multiple Sclerosis Research

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Multiple Sclerosis

Part of the book series: Ettore Majorana International Science Series ((PHYSC,volume 16))

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Abstract

The inflammatory demyelinating plaque in the brain and spinal cord is the hallmark of multiple sclerosis (MS) pathology (Charcot, 1868; Marburg, 1906; Dawson, 1915). The pathology consists of primary demyelination (Marburg, 1906) and chronic perivenous inflammation, mainly located around larger veins and venules (Seitelberger, 1970). It was noted at the beginning of this century that plaques show a high variability of structural changes, i.e., from extensive cellular infiltration to few cells present, various degrees of axonal and oligodendroglia loss, and various degrees of remyelination, gliosis and connective tissue reaction. These observations lead to a large number of different, sometimes even contradictory pathogenetic theories of this disease (Dawson, 1915; Lassmann, 1983).

To Mrs. Alma Sagan, the best fighter of the MS malady and all those heros who fight back the disease, this paper is dedicated.

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Authors and Affiliations

  1. NYS Institute for Basic Research in Developmental, Disabilities, Staten Island, NY, 10314, USA

    H. M. Wisniewski, G. Schuller-Levis, P. D. Mehta & R. E. Madrid

  2. Neurological Institute, University of Vienna, Vienna, Austria

    Hans Lassmann

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  1. H. M. Wisniewski
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  2. Hans Lassmann
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  3. G. Schuller-Levis
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  4. P. D. Mehta
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  5. R. E. Madrid
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Editors and Affiliations

  1. Neurological Department, Univeristy of Milan, Milan, Italy

    G. Scarlato

  2. University of Oxford, Oxford, UK

    W. B. Matthews

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Wisniewski, H.M., Lassmann, H., Schuller-Levis, G., Mehta, P.D., Madrid, R.E. (1984). Pathogenesis of Perivenous and Demyelinating Encephalomyelitis and Its Relevance for Multiple Sclerosis Research. In: Scarlato, G., Matthews, W.B. (eds) Multiple Sclerosis. Ettore Majorana International Science Series, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2403-4_1

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