Abstract
Macrophages play a central role in host resistance to microbial infections. Ingestion and subsequent killing of pathogenic microorganisms are necessary for prohibiting the spread of infectious agents. However, microorganisms or their products have the potential to severely compromise host immune defenses by altering the normal functioning of macrophages. For example, Legionella pneumophila is a facultative intracellular pathogen that grows within monocytes and macrophages (2,13,18). Proliferation of the organisms within these cells occurs even in the presence of serum antibody and complement (14,15). L. pneumophila appears to evade destruction within phagocytes by inhibiting phagosome-lysosome fusion (12). Thus, the prevention of phagolysosome fusion impairs this normal macrophage function which can lead to decreased host resistance.
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© 1986 Plenum Press, New York
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Becker, J., Grasso, R.J., Friedman, H. (1986). Transient Suppression of Yeast Phagocytosis Induced by Legionella Pneumophila in Cultures of Murine Resident Peritoneal Macrophages. In: Szentivanyi, A., Friedman, H., Nowotny, A. (eds) Immunobiology and Immunopharmacology of Bacterial Endotoxins. University of South Florida International Biomedical Symposia Series, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2253-5_24
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DOI: https://doi.org/10.1007/978-1-4613-2253-5_24
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