Immunobiology and Immunopharmacology of Bacterial Endotoxins

  • Andor Szentivanyi
  • Herman Friedman
  • Alois Nowotny

Table of contents

  1. Front Matter
    Pages i-x
  2. Introductory Section

  3. Chemical and Molecular Characteristics of Endotoxins

  4. Physiological and Pharmacological Effects of Endotoxins

    1. Front Matter
      Pages 97-97
    2. John J. Spitzer, Gregory J. Bagby, Charles H. Lang
      Pages 99-110
    3. Michael R. Yelich, Linda Witek-Janusek, James P. Filkins
      Pages 111-132
    4. Joseph F. Williams, Andor Szentivanyi
      Pages 159-169
    5. Raymond E. Shepherd, Charles H. Lang, Brent A. Brumfield, Norman W. Robie, Karen R. DuSapin, Kathleen H. McDonough
      Pages 171-185
    6. John W. Hadden, Ann Galy, Elba M. Hadden, J. L. Touraine, Ronald G. Coffey
      Pages 187-198
  5. Immunogenicity and Non-Specific Effects of Endotoxin

    1. Front Matter
      Pages 199-199

About this book

Introduction

Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le. , bacterial endo­ toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.

Keywords

Antigen antibiotics bacteria immunobiology infection infections interferon leukemia lymphocytes macrophages pharmacology proteins research retroviruses virus

Editors and affiliations

  • Andor Szentivanyi
    • 1
  • Herman Friedman
    • 1
  • Alois Nowotny
    • 2
  1. 1.University of South Florida College of MedicineTampaUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-2253-5
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9319-4
  • Online ISBN 978-1-4613-2253-5
  • About this book