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Culture of Rabies Virus in Vitro

  • Chapter
Rabies

Part of the book series: Developments in Veterinary Virology ((DVVI,volume 7))

Abstract

Since the early 1950s, cell culture systems have been developed which have led to the understanding of much of the structure and biology of rabies virus and have also made it possible to grow the virus in sufficient quantities for vaccine production. In this chapter, we give a brief historical account of the production of the wide variety of cell systems available today and of how they have been employed in the various areas of research and virus assay. The information gained in terms of virus infection and pathogenesis in vivo is discussed, as are the ways in which cell cultures are now applied in the important areas of diagnosis and epizootiology of the disease. There is a short résumé on vaccine production and the problems of transferring the appropriate technology to the developing countries. We conclude by considering the many questions that remain and how tissue culture techniques may assist in providing some of the answers.

formerly of the Animal Virus Research Institute, Pirbright, Woking, Surrey, England

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Authors and Affiliations

  1. 238 Weybourne Road, Aldershot, Hants, England

    Joan Crick

  2. Central Veterinary Laboratory, Ministry of Agriculture, Fisheries and Food, New Haw, Weybridge, Surrey, England

    Arthur King

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  1. Joan Crick
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Editors and Affiliations

  1. University of Toronto, Toronto, Ontario, Canada

    James B. Campbell

  2. Animal Diseases Research Institute, Agriculture Canada, Nepean, Canada

    K. M. Charlton

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Crick, J., King, A. (1988). Culture of Rabies Virus in Vitro . In: Campbell, J.B., Charlton, K.M. (eds) Rabies. Developments in Veterinary Virology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1755-5_3

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