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The Biology of Nerve Growth Factor in Vivo

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Neurobiology of Amino Acids, Peptides and Trophic Factors

Part of the book series: Topics in the Neurosciences ((TINS,volume 8))

Abstract

A major theme in developmental neurobiology is the role of target tissues in the maintenance of the neurons that innervate those targets. During the development of the nervous system, more neurons are produced and send axons to targets than survive in the mature animal. Typically about 50% of the neurons projecting to a given structure will die during a restricted period. This has been termed naturally occurring cell death. Several lines of evidence indicate that the size of the target field is a major determinant of this cell death: Removal of the target results in greatly increased cell death, while expansion of the target decreases cell death (for reviews, see Refs. 1 and 2).

The authors thank our many colleagues who contributed the various studies mentioned in this paper. Work from the authors’ laboratories was supported by NIH grants HL20604, NS18071, and by grants from the March of Dimes Birth Defects Foundation and from Monsanto Company.

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Authors
  1. Eugene M. Johnson Jr.
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  2. Pamela T. Manning
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  3. Christine Wilcox
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Editor information

Editors and Affiliations

  1. Washington University School of Medicine, USA

    James A. Ferrendelli , Robert C. Collins  & Eugene M. Johnson ,  & 

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© 1988 Kluwer Academic Publishers

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Johnson, E.M., Manning, P.T., Wilcox, C. (1988). The Biology of Nerve Growth Factor in Vivo. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1721-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8969-2

  • Online ISBN: 978-1-4613-1721-0

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