Skip to main content

Tumor-Mediated Immunosubversion: Role of Dietary Essential Fatty Acid

  • Chapter
Carcinogenesis and Dietary Fat

Part of the book series: Prostaglandins, Leukotrienes, and Cancer ((PLAC,volume 6))

Abstract

It is said that “we are what we eat”. That, we would all agree, applies to our outward physical appearance - our stature and weight. We would also agree that our diet must include certain essential nutrients for our body to function normally. Now we are being told that nutrition may also be a critical factor in promoting or reducing our risk for certain diseases. On this point, agreement is not general.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Plescia, O.J., Smith, A. and Grinwich, K. (1975) Subversion of the immune system by tumor cells and the role of prostaglandins. Proc. Natl. Acad. Sci. U.S.A. 72:1848–1852.

    Article  PubMed  CAS  Google Scholar 

  2. Plescia, O.J., Smith, A., Grinwich, K. and Feit, C. (1975) The problem of cancer immunotherapy in perspective. In: “Fundamental Aspects of Neoplasia”. Gottlieb, A., Plescia, O.J. and Bishop, D. (eds.), Academic Press, New York, pp. 139–151.

    Google Scholar 

  3. Bennett, A., DelTacca, M., Stamford, I.F., et al. (1977) Prostaglandins from tumors of human large bowel. Brit. J. Cancer 35:881.

    Article  PubMed  CAS  Google Scholar 

  4. Rolland, P.H., Martin, P.M., Jacquemier, J., et al. (1980) Prostaglandins in human breast cancer: Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells. J. Natl. Cancer Inst. 64:1061.

    PubMed  CAS  Google Scholar 

  5. Tashjian, A., Jr., Voelkel, E., Levine, L. and Goldhaber, P. (1972) Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E2. J. Exp. Med. 136:1329.

    Article  PubMed  CAS  Google Scholar 

  6. Pelus, L.M. and Strausser, H.R. (1977) Prostaglandins and the immune response. Life Sci. 20:903.

    Article  PubMed  CAS  Google Scholar 

  7. Goldyne, M.E. and Stobo, J.D. (1981) Immunoregulatory role of prostaglandins and related lipids. CRC Critical Reviews in Immunology, 2:189.

    CAS  Google Scholar 

  8. Goodwin, J. and Webb, D. (1980) Regulation of the immune response by prostaglandins. Clin. Immunol. Immunopathol. 15:106–122.

    Article  CAS  Google Scholar 

  9. Kunkel, S.L. and Chensue, S.W. (1984) Prostaglandins and the immune response. Adv. Inflamm. Res. 7:93–109.

    CAS  Google Scholar 

  10. Gemsa, D. (1981) Stimulation of prostaglandin E release from macrophages and possible role in the immune response. Lymphokines Vol. II. (4), Pick, E. (ed.), Academic Press, New York, pp. 335–375.

    Google Scholar 

  11. Goodwin, J.S. (1980) Prostaglandin regulation of the immune response. [Letter] Cell. Immunol. 52(1):106–122.

    Article  Google Scholar 

  12. Plescia, O.J., Pontieri, G.M., Brown, J., Racis, S., Ippoliti, F., Bellelli, L., Sezzi, M.L. and Lipari, M. (1984) Amplification by macrophages of prostaglandin-mediated immunosuppression in mice bearing syngeneic tumors. Prost. Leuko. & Med. 16:205–223.

    Article  CAS  Google Scholar 

  13. Levine, L. (1982) Stimulation of cellular prostaglandin production by phorbolesters and growth factors and inhibition by cancer chemopreventive agents. In: “Prostaglandins and Cancer: First Internatinal Conference”. Powles, T.J., Bockman, R.S., Honn, K.V. and Ramwell, P., (eds.), Alan R. Liss, Inc., New York, p. 189.

    Google Scholar 

  14. Samuelsson, B., Bargeat, P., Hammerstrom, S., et al. (1980) Leukotrienes: A new group of biologically active compounds. In: “Advances in Prostaglandin and Thomboxane Research”. Samuelsson, B., Ramwell, P. and Paoletti, R. (eds.), Raven Press, New York, pp. 1–18.

    Google Scholar 

  15. Salomon, J.A. and Flower, R.J. (1982) In: “Methods in Enzymology”. W. Lands and W. Smith (eds.), Academic Press, New York, Vol. 86, p. 47.

    Google Scholar 

  16. Kondo, M., Koshira, Y., Kawamura, M. and Mureta, S. (1983) Biochem. J. 212:219–222.

    PubMed  CAS  Google Scholar 

  17. Demers, I.M. (1984) The effects of prostaglandins. Diagnostic Medicine, pp. 37–45.

    Google Scholar 

  18. Racis, S.P. (1986) Prostaglandins as Physiological Immunoregulators. Ph.D. Thesis, Rutgers, The State University and The University of Medicine and Dentistry of New Jersey.

    Google Scholar 

  19. Webb, D.R., Rogers, T.J. and Nowowiejski, I. (1980) Endogenous prostaglandin synthesis and the control of lymphocyte function. Proc. Natl. Acad. Sci. U.S.A. 332:262–270.

    Google Scholar 

  20. Goodwin, J.S., Selinger, D.S., Messner, R.P. and Reed, W.P. (1978) Effect of indomethacin in vivo on humoral and cellular immunity in humans. Infect. Immun. 19:430.

    PubMed  CAS  Google Scholar 

  21. Loose, L. and DiLuzio, N. (1973) Effect of prostaglandin E1 on cellular and humoral immune responses. J.R.E.S. 13:70.

    CAS  Google Scholar 

  22. Webb, D.R. and Nowowiejski, I. (1977) The role of prostaglandins in the control of the primary 19S immune response to SRBC. Cell Immunol. 33:1.

    Article  PubMed  CAS  Google Scholar 

  23. Webb, D. and Osheroff, P. (1976) Antigen stimulation of prostaglandin synthesis and control of the immune responses. Proc. Natl. Acad. Sci. U.S.A. 73:1300.

    Article  PubMed  CAS  Google Scholar 

  24. Herscowitz, H.B. and Stylos, W.A. (1975) Prostaglandin induced enhancement of the in vitro anamnestic response. Prost. 10:1848.

    Google Scholar 

  25. Hokama, Y., Matsuo, M., Lam, M. et al. (1980) Regulatory role of prostaglandins in the primary and secondary immune response to SRBC in mice. In: “Advances in Prostaglandin and Thromboxane Research”. Samuelsson, B., Ramwell, P. and Paoletti, R. (eds.), Raven Press, New York, pp. 1669–1674.

    Google Scholar 

  26. Rogers, T.J., Campell, L., Calhoun, K., Nowowiejski, I. and Webb, D.R. (1982) Suppression of B cell and T cell responses by the prostaglandin induced T cell derived suppressor (PITS). Cell. Immunol. 66:269.

    Article  PubMed  CAS  Google Scholar 

  27. Zimecki, M. and Webb, D.R. (1976) The regulation of the immune response to T-independent antigens by prostaglandins and B cells. J. Immunol. 117:2158–2164.

    PubMed  CAS  Google Scholar 

  28. Droller, M., Schneider, M. and Perlman, P. (1978) A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells. Cell. Immunol. 39:166.

    Google Scholar 

  29. Leung, K. and Mihich, E. (1980) Prostaglandin modulation of development of cell-mediated immunity in culture. Nature 288:597.

    Article  PubMed  CAS  Google Scholar 

  30. Brunda, M., Herberman, R. and Holden, H. (1980) Inhibition of murine natural killer cell activity by prostaglandins. J. Immunol. 124:2682.

    PubMed  CAS  Google Scholar 

  31. Bray, M.A., Gordon, D. and Morley, J. (1974) Role of prostaglandins in reactions of cellular immunity. Int. J. Pharmacol. 52:4530.

    Google Scholar 

  32. Plescia, O.J., Yamamoto, T. and Shimamura, T. (1975) Cyclic AMP and immune responses: Changes in the splenic level of cyclic AMP during the response of mice to antigen. Proc. Natl. Acad. Sci. U.S.A. 72:888–891.

    Article  PubMed  CAS  Google Scholar 

  33. Braun, W. (1974) Regulatory factors in the immune response: Analysis and perspective. In: “Cyclic AMP, Cell Growth, and the Immune Response”. Braun, W., Lichtenstein, L.M. and Parker, C.W. (eds.), Springer-Verlag, New York, pp. 4–23.

    Google Scholar 

  34. Skelly, R., Steinberg, A.D. and Plescia, O.J. (1978) Regulation of antigen-induced changes in cyclic nucleotide levels in NZB/W F1 mice. Cell. Immunol. 36:282–293.

    Article  Google Scholar 

  35. Bourne, H.R., Lichtenstein, L.M., Melmon, K.L., Henney, C.S., Weinstein, Y. and Shearer, G.M. (1974) Modulation of inflammation and immunity by cyclic AMP. Science 184:19–28.

    Article  PubMed  CAS  Google Scholar 

  36. Goodwin, J.S., Kaszubowski, P.A. and Williams, R.C., Jr. (1979) Cyclic adenosine monophosphate response to prostaglandin E2 on subpopulations of human lymphocytes. J. Exp. Med. 150(5): 1260–1264.

    Article  PubMed  CAS  Google Scholar 

  37. Watson, J., Epstein, R. and Cohn, M. (1973) Cyclic nucleotides as intracellular mediators of the expression of antigen-sensitive cells. Nature 246:405.

    Article  PubMed  CAS  Google Scholar 

  38. Parker, C.S., Sullivan, T.J. and Wedner, H.J. (1974) Cyclic AMP and the immune response. In: “Advances in Cyclic Nucleotide Research”. Robeson, G.A. and Greengard, P. (eds.), Raven Press, New York, Vol. IV, p. 1.

    Google Scholar 

  39. Hoffeld, J.T., Metzger, Z. and Oppenheim, J.J. (1981) In: “Lymphokines”, Vol. II. Pick, E. (ed.), Academic Press, New York, pp. 469–482.

    Google Scholar 

  40. Bray, M.A., Gordon, D. and Morley, J. (1976) Regulation of lymphokine secretion by prostaglandins. Agents Action 6:71.

    Article  Google Scholar 

  41. Dawson, W. (1982) The role of arachidonic acid products in macrophage function. In: “Prostaglandins and Related Lipids”, Vol. II. Powles, T.J., Bockman, R.S., Honn, K.V. and Ramwell, P. (eds.), Alan R. Liss, Inc., New York, pp. 609–617.

    Google Scholar 

  42. Humes, J.L., Bonney, R.J., Pelus, L., et al. (1977) Macrophage synthesis and release prostaglandins in response to inflammatory stimuli. Nature 269:149–151.

    Article  PubMed  CAS  Google Scholar 

  43. Kurland, J.L. and Bockman, R. (1978) Prostaglandin E production by human monocytes and mouse peritoneal macrophages. J. Exp. Med. 147:952.

    Article  PubMed  CAS  Google Scholar 

  44. Pelus, L.M., Bockman, R.S. (1979) Increased prostaglandin synthesis by macrophages from tumor-bearing mice. J. Immunol. 123:2118–2122.

    PubMed  CAS  Google Scholar 

  45. Salmon, S.E. (1982) Interrelationship of endogenous macrophages, prostaglandin synthesis and tumor cell clonogenicity in human tumor biopsies. In: “Prostaglandins and Related Lipids”, Vol. II. Powles, T.J., Bockman, R.S., Honn, K.V. and Ramwell, P. (eds.), Alan R. Liss, Inc., New York, pp. 633–649.

    Google Scholar 

  46. Stenson, W.F. and Parker, C.W. (1980) Editorial: Prostaglandins, Macrophages, and Immunity. J. Immunol. 125:1.

    PubMed  CAS  Google Scholar 

  47. Goldyne, M. and Stobo, J. (1980) Prostaglandin E2 as a modulator of macrophage-T lymphocyte interaction. J. Invest. Dermat. 74:297.

    Article  CAS  Google Scholar 

  48. Plescia, O.J., Grinwich, K. and Plescia, A.M. (1976) Subversive activity of syngeneic tumor cells as an escape mechanism from immune surveillance and the role of prostaglandins. Ann. N.Y. Acad. Sci. 276:455.

    Article  PubMed  CAS  Google Scholar 

  49. Bockman R.S. (1980) Stage-dependent reduction in T colony formation in Hodgkin’s disease. J. Clin. Invest. 66:528.

    Article  Google Scholar 

  50. Goodwin, J.S., Messner, R.P., Bankhurst, A.D., Peake, G.T., Saiki, J.H. and Williams, R.G., Jr. (1977) Prostaglandin producing suppressor cells in Hodgkin’s disease. N. Engl. J. Med. 297:-963–968.

    Article  PubMed  Google Scholar 

  51. Fischer, R.I.U. and Bostwick-Burton, H. (1982) Depressed T cell AH3 proliferative responses in Hodgkins disease. J. Immunol. 129:1770.

    Google Scholar 

  52. Bockman, R.S. (1982) Prostaglandins, T Lymphocyte precursors and cancer. In: “Prostaglandins and Related Lipids”. Powles, T.J., Bockman, R.S., Honn, K.V. and Ramwell, P. (eds.), Alan R. Liss, New York, pp. 415–423.

    Google Scholar 

  53. Brown, J.W. (1986). Tumor-mediated Immunosuppression and neoplasia, Ph.D. Thesis, Rutgers - The State Unviersity, New Brunswick, NJ.

    Google Scholar 

  54. Grinwich, K. and Plescia, O.J. (1977) Tumor-mediated immunosuppression: Prevention by inhibitors of prostaglandin synthesis. Prostaglandins 14:1175–1181.

    Article  PubMed  CAS  Google Scholar 

  55. Pelus, L.M., Strausser, H.R. (1976) Indomethacin enhancement of spleen-cell responsiveness to mitogen stimulation in tumorous mice. Int. J. Cancer 18(5): 653–660.

    Article  PubMed  CAS  Google Scholar 

  56. Kollmorgen, G.M., Langley, R.E., Kasanke, S.O., et al. (1982). In: “First International Conference on the Modulation and Mediation of Cancer by Vitamins”. Meyskins and Prasad (eds.), Karger Press.

    Google Scholar 

  57. Committee on Diet, Nutrition and Cancer, National Academy of Sciences (1982). Diet, Nutrition and Cancer, National Academy Press, Washington, D.C.

    Google Scholar 

  58. Berenblum, I. and Shubik, P. (1947) A new quantitative approach to the study of the stages of chemical carcinogenesis in the mouse skin. Br. J. Cancer 1:373–391.

    Google Scholar 

  59. Boutwell, R.K. (1974) The function and mechanism of promoters of carcinogenesis. CRC Crit. Rev. Toxicol. 2:419–466.

    Article  PubMed  CAS  Google Scholar 

  60. Hennings, H., Shores, R., Warik, M., et al. (1983) Malignant conversion of mouse skin tumor promoters is increased by tumor-initiators and unaffected by promoters. Nature 304:67–69.

    Article  PubMed  CAS  Google Scholar 

  61. Verma, A.K., Ashendel, C.L. and Boutwell, R.K. (1980) Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins and tumor promotion caused by TPA. Cancer Res. 40:308–315.

    PubMed  CAS  Google Scholar 

  62. Kersey, J.N., Spector, B.D. and Good, R.A. (1973) Immunodeficiency and cancer. Adv. Cancer Res. 18:211.

    Article  PubMed  CAS  Google Scholar 

  63. Lahane, J.E. and Lane, M. (1974) Immunocompetence in advanced cancer patients prior to chemotherapy. Oncology 30:458.

    Article  Google Scholar 

  64. Hersh, E.M., Gutterman, J.U., Movliget, G.M., et al. (1976) Immunocompetence, immunodeficiency and prognosis in cancer. Ann. N.Y. Acad. Sci. 276:386–406.

    Article  PubMed  CAS  Google Scholar 

  65. Hiel, V., Horokova, Z., Shaff, R.E., et al. (1976) Alteration of tumor growth by aspirin and indomethacin: Studies with two transplanted tumors in mice. Eur. J. Phrmacol. 37:367.

    Article  Google Scholar 

  66. Pollard, M. and Lucker, P.H. (1981) Treatment of chemically induced intestinal cancers with indomethacin. Proc. Natl. Acad. Sci. U.S.A. 167:161.

    CAS  Google Scholar 

  67. Bennett, A. (1979) Prostaglandins and cancer. In: “Practical Applications of Prostaglandins and Their Synthesis Inhibitors”. Karim, S. (ed.), University Park Press, Baltimore, pp. 149–189.

    Google Scholar 

  68. Plescia, O.J., Grinwich, K., Sheridan, J. and Plescia, A.M. (1978) Subversion of the immune system by tumors as a mechanism of their escape from immune rejection. Prog. Biochem. Pharmacol. 14:123–138.

    PubMed  CAS  Google Scholar 

  69. Strausser, H. and Humes, J. (1975) Prostaglandin synthesis inhibition: Effect on bone changes and sarcoma tumor induction in Balb/mice. Int. J. Cancer 15:724.

    Article  PubMed  CAS  Google Scholar 

  70. Trevisani, A., Ferretti, E., Capuzzo, A. and Tomasi, V. (1980) Elevated levels of PGE2 in Yoshida hepatoma and the inhibition of tumor growth by nonsteroidal anti-inflammatory drugs. Br. J. Cancer 41:341–347.

    Article  PubMed  CAS  Google Scholar 

  71. Lynch, M.R. and Salomon, J. (1979) Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. J. Natl. Cancer Inst. 62:117.

    PubMed  CAS  Google Scholar 

  72. Goodwin, J.S. (1980) Prostaglandin synthesis inhibitors as immunoadjuvants in the treatment of cancer. J. Immunopharacol. 2:397.

    Article  CAS  Google Scholar 

  73. Plescia, O.J. (1982) Does prostaglandin synthesis effect in vivo tumor growth by altering tumor/host balance? In: “Prostaglandins and Cancer: First International Conference”. Powles, T.J., Bakman, R.S., Honn, K.V. and Ramwell, P. (eds.), Alan R. Liss, New York, pp. 205–223.

    Google Scholar 

  74. Bennett, A., Charlier, E.M., McDonald, A.M., et al. (1977). Prostaglandins and breast cancer. Lancet 2:624.

    Article  PubMed  CAS  Google Scholar 

  75. Wynder, E.L., Rose, D.P. and Cohen, L.A. (1986) Diet and breast cancer in causation and therapy. Cancer 58:1804–1813.

    Article  PubMed  CAS  Google Scholar 

  76. Hirayama, T. (1978) Epidemiology of breast cancer with special reference to the role of diet. Prev. Med. 7:173–195.

    Article  PubMed  CAS  Google Scholar 

  77. Willett, W.C., Stampfer, M.J., Colditz, G.X., et al. (1987) Dietary fat and the risk of breast cancer. New Engl. J. Med. 316:22–28.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers, Boston

About this chapter

Cite this chapter

Plescia, O.J., Brown, J., Lombardi, D., Lenti, L., Racis, S., Pontieri, G.M. (1989). Tumor-Mediated Immunosubversion: Role of Dietary Essential Fatty Acid. In: Abraham, S. (eds) Carcinogenesis and Dietary Fat. Prostaglandins, Leukotrienes, and Cancer, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1585-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1585-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8878-7

  • Online ISBN: 978-1-4613-1585-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics