Abstract
With sufficient dose and qualities of radiation, cell injury causes release of important circulating mediators, cell death and, in those cells which do survive, delayed effects or subtle changes in cell physiology which can sensitize them to other insults. Gastrointestinal damage occurs at the upper end of the intermediate dose range, but hematopoietic damage occurs at the lower end (i.e. 150–200 cGy). However, subtle metabolic and physiologic deficiencies may occur in other organ systems. For example, at intermediate doses of radiation, cardiovascular changes may not be apparent, but these doses may sensitize the individual to sepsis or certain therapeutic drugs which also alter cardiovascular physiology.
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Cockerham, L.G., Forcino, C.D. (1988). Post-Irradiation Alterations In Cerebral Blood Flow. In: McCormack, P.D., Swenberg, C.E., Bücker, H. (eds) Terrestrial Space Radiation and Its Biological Effects. Nato ASI Series, vol 154. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1567-4_37
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DOI: https://doi.org/10.1007/978-1-4613-1567-4_37
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