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Stretch-Activated Ion Channels

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Molecular Biology of Membrane Transport Disorders

Abstract

Mechanosensitive or stretch-activated (SA) channels respond to membrane stress by changes in open probability. These channels exist in auditory cells, stretch receptors, muscle spindles, vascular endothelium, and other neurosensory tissues where their physiological function seems readily apparent. It is less obvious why nonexcitable cells, such as those of blood and epithelial tissues, need channels that respond to mechanical stimuli. Clearly, all cells must cope with the dual problems of volume regulation and electrolyte homeostasis. Since the primary function of epithelia is salt and water transport, these cells face both extracellular and intracellular osmotic challenges. For example, Na-transporting epithelia in the intestine and kidney must accommodate significant variations in net solute uptake without suffering destructive changes in cell volume, caused by slight discrepancies between influx and efflux.1

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Cornell University Medical College, New York, New York, 10021, USA

    Henry Sackin

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  1. Henry Sackin
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Editor information

Editors and Affiliations

  1. University of Texas Medical School at Houston, Houston, Texas, USA

    Stanley G. Schultz

  2. University of Arkansas College of Medicine, Little Rock, Arkansas, USA

    Thomas E. Andreoli

  3. Case Western Reserve University, Cleveland, Ohio, USA

    Arthur M. Brown

  4. The Johns Hopkins University, Baltimore, Maryland, USA

    Douglas M. Fambrough

  5. Yale University School of Medicine, New Haven, Connecticut, USA

    Joseph F. Hoffman

  6. University of Iowa College of Medicine, Iowa City, Iowa, USA

    Michael J. Welsh

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© 1996 Plenum Press, New York

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Sackin, H. (1996). Stretch-Activated Ion Channels. In: Schultz, S.G., Andreoli, T.E., Brown, A.M., Fambrough, D.M., Hoffman, J.F., Welsh, M.J. (eds) Molecular Biology of Membrane Transport Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1143-0_11

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  • DOI: https://doi.org/10.1007/978-1-4613-1143-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8446-8

  • Online ISBN: 978-1-4613-1143-0

  • eBook Packages: Springer Book Archive

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