Molecular Biology of Membrane Transport Disorders

  • Stanley G. Schultz
  • Thomas E. Andreoli
  • Arthur M. Brown
  • Douglas M. Fambrough
  • Joseph F. Hoffman
  • Michael J. Welsh

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Jonathan Covault
    Pages 11-45
  3. William P. Dubinsky, Otilia Mayorga-Wark
    Pages 73-86
  4. William A. Catterall
    Pages 129-145
  5. C. K. Ifune, Joe Henry Steinbach
    Pages 147-168
  6. David H. MacLennan, Michael S. Phillips, Yilin Zhang
    Pages 181-200
  7. Henry Sackin
    Pages 201-222
  8. Douglas M. Fambrough, Giuseppe Inesi
    Pages 223-241
  9. Michael M. Gottesman, Suresh V. Ambudkar, Marilyn M. Cornwell, Ira Pastan, Ursula A. Germann
    Pages 243-257
  10. Mark Donowitz, Susan A. Levine, C. H. Chris Yun, Steven R. Brant, Samir Nath, Jeannie Yip et al.
    Pages 259-275
  11. Ronald S. Kaplan
    Pages 277-302
  12. Victoria P. Knutson, Patricia V. Donnelly, Maria M. Lopez-Reyes, Yvonne L. O. Balba
    Pages 303-319
  13. Mariel Birnbaumer, Lutz Birnbaumer
    Pages 321-366
  14. Laurinda A. Jaffe
    Pages 367-378
  15. John R. Sachs
    Pages 379-406

About this book

Introduction

When the six of us gathered to start planning for what was to be the Third Edition of Physiology of Membrane Disorders, it was clear that since 1986, when the Second Edition appeared, the field had experienced the dawning of a new era dominated by a change in focus from phenomenology to underlying mechanisms propelled by the power of molecular biology. In 1985, detailed molecular information was available for only three membrane transporters: the lac permease, bacterial rhodopsin, and the acetylcholine receptor. During the decade that has since elapsed, almost all of the major ion channels and transport proteins have been cloned, sequenced, mutagenized, and expressed in homologous as well as heterologous cells. Few, if any, of the transporters that were identified during the previous era have escaped the probings of the new molecular technologies and, in many instances, considerable insight has been gained into their mechanisms of function in health and disease. Indeed, in some instances novel, unexpected transporters have emerged that have yet to have their functions identified. The decision to adopt the new title Molecular Biology of Membrane Transport Disorders was a natural outgrowth of these considerations.

Keywords

ATPase Biomembran Escherichia coli Pathogene Transporter cells erythrocyte molecular biology pathophysiology physiology signal transduction

Editors and affiliations

  • Stanley G. Schultz
    • 1
  • Thomas E. Andreoli
    • 2
  • Arthur M. Brown
    • 3
  • Douglas M. Fambrough
    • 4
  • Joseph F. Hoffman
    • 5
  • Michael J. Welsh
    • 6
  1. 1.University of Texas Medical School at HoustonHoustonUSA
  2. 2.University of Arkansas College of MedicineLittle RockUSA
  3. 3.Case Western Reserve UniversityClevelandUSA
  4. 4.The Johns Hopkins UniversityBaltimoreUSA
  5. 5.Yale University School of MedicineNew HavenUSA
  6. 6.University of Iowa College of MedicineIowa CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-1143-0
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8446-8
  • Online ISBN 978-1-4613-1143-0
  • About this book