Abstract
In the last few years, some phenotypic and functional aspects of thyroid infiltrating T lymphocytes in Hashimoto’s thyroiditis (HT) have been defined1-5. Most thyroid T cells have the CD8+cytotoxic/suppressor phenotype and a proportion of them express receptors for IL-2, suggesting their in vivo activation4. In addition, most of T-cell clones established from HT infiltrates appeared to be progenies of CD8+ T cells with natural killer (NK) activity. Here we report an analysis at clonal level of T lymphocytes infiltrating HT glands in which their ability to produce interleukin-2 (IL-2) and interferon-gamma (IFN-γ) was evaluated.
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References
M.C. Bene et al. , - Clin exp Immunol 52:311 (1983).
G.F. Del Prete et al. , - J Clin Endocrinol Metab 62:52 (1986).
M. Bagnasco et al. , - Int Archs Allergy appl Immunol (in press).
G.F. Del Prete et al. , - Clin exp Immunol 64:140 (1986).
Y. Iwatani et al. , - J Clin Endocrinol Metab 63:695 (1986).
W.L. Farrar et al. , - J Immunol 126:1120 (1981).
J.Y. Djeu et al. , - J Exp Med 156:1222 (1982).
J.R. Klein and M.J. Bevan - J Immunol 130:1780 (1983);
G. Trinchieri and B. Perussia - Immunol Today 6:131 (1985).
S. Romagnani et al. , - J Immunol 136:3513 (1986).
H.J. Leibson et al. , - Nature 309:799 (1984).
M. Brunswick and P. Lake - J Exp Med 161:953 (1985).
S.M. McLachlan et al. , - Clin exp Immunol 52:45 (1983).
G.F. Bottazzo et al. , - Lancet 2:1115 (1983).
T.F. Davies - J Clin Endocrinol Metab 61:418 (1985).
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© 1987 Plenum Press, New York
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Tiri, A., Del Prete, G.F., Mariotti, S., Pinchera, A., Romagnani, S., Ricci, M. (1987). High Frequency of Interferon-γ Producing T Cells In Thyroid Infiltrates of Patients With Hashimoto’s Thyroiditis. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_42
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DOI: https://doi.org/10.1007/978-1-4613-0945-1_42
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8258-7
Online ISBN: 978-1-4613-0945-1
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