Abstract
Various experimental transplantation models have been used in order to investigate the physiology, pathophysiology and treatment of grafted tissues under in vivo conditions(1). Since in homologous and especially in heterologous transplantation models severe immunological problems exist, the description of thymus aplastic nude(nu/nu)mice(2)and nude(rnu/ rnu)rats(3)has stimulated experimental transplantation research. The genes governing thymic agenesis and hairlessness proved to be linked and inherited as autosomal traits. This effect is linked with loss’ of immunocompetend T-lymphocytes, resulting in a lack of immune resistance. If nude mice or rats are used as recipients, hetero(xeno-)transplantation can be achieved without immunosuppressive therapy. Beside malignant and also various benign human tissue were successfully transplanted to nude mice.
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References
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© 1987 Plenum Press, New York
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Usadel, K.H., Paschke, R., Teuber, J., Schwedes, U. (1987). Heterotransplantation of Autoimmune Human Thyroid to Nude Mice as a Tool for in Vivo Autoimmune Research. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_24
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DOI: https://doi.org/10.1007/978-1-4613-0945-1_24
Publisher Name: Springer, Boston, MA
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