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Regulation of Growth and Secretion of Growth Factors by 17 B-Estradiol and V-RASH Oncogene in Human Mammary Carcinoma Cell Lines

  • Chapter
Cellular and Molecular Biology of Mammary Cancer

Abstract

Breast cancer is unique among cancers in that its growth is strongly regulated in about one third of clinical cases by estrogenic hormones or antiestrogenic antagonists (1). Breast cancer occurs in women who never had functional ovaries with only 1% of the frequency of that in women with intact ovaries. Thus, estrogens are stimulatory, at least initially, in nearly all breast cancers. This hormonal component of growth control appears to be a remnant of normal, differentiated epithelial proliferation. During puberty or pregnancy-lactation, estrogen exerts mitogenic, anabolic and secretory effects on mammary epithelium. While estrogen is a proximate mitogen for either normal or malignant breast epithelium, the hypothalamus-pituitary axis is indirectly in control of ovarian estrogen secretion by virtue of gonadotropin releasing hormone and gonadotropin stimulation (2).

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Abbreviations

E2 :

estradiol

IMEM:

improved nodified Eagle’ medium

CM:

conditional meduim

CME2 :

medium conditioned by cells petreated with estradiol

HPLC:

high performance liquid chromotography

PDFG:

platelet-derived growth factor

EGF:

epidremal growth factor

IGF:

insulin-like growth factor

TGF:

transforming growth factor

FGF:

fibrolast growth factor

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Authors and Affiliations

  1. Medical Breast Cancer Section Medicine Branch, National Cancer Institute National Institutes of Health, Bethesda, MD, 20892, USA

    Robert B. Dickson & Marc E. Lippman

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  1. Robert B. Dickson
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  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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Dickson, R.B., Lippman, M.E. (1987). Regulation of Growth and Secretion of Growth Factors by 17 B-Estradiol and V-RASH Oncogene in Human Mammary Carcinoma Cell Lines. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_13

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_13

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