Abstract
Although neuropathological and epidemiological studies have long indicated Alzheimer’s dementia (AD) as a major cause of cognitive deterioration in the elderly (Larsson et al., 1963; Kay et al, 1964; Roth et al, 1967), the reports of Davies and Maloney (1976) and Bowen et al (1976) describing selective deficits in cholinergic synaptic neurochemical markers in the cortex and hippocampus of Alzheimer’s patients provoked a paradigm shift in the thinking of the neuroscientific community concerning the pathobiology of this disorder. Thus, in the 7-year period prior to these two publications, approximately 30 articles per annum appeared in the medical/scientific literature on AD, whereas in the 5-year period after these reports, the annual number of publications increased nearly 10-fold. While other factors such as the increasing interest in geriatric medicine and the growing appreciation of the social and economic implications of AD with regard to the increasing lifespan of individuals in Western society undoubtedly contributed to the burgeoning medical and scientific interest in the disorder, the discovery of selective neurotransmitter deficits in AD clearly had a tremendous impact.
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Adams, C. E., Cepeda, C, Boylan, M. K., Fisher, R. S., Hull, C. D., Buchwald, N. A., Wainer, B. H., and Levine, M. S., 1986, Basal forebrain neurons have axon collaterals that project to widely divergent cortical areas in the cat, Brain Res. 397: 365–371.
Adem, A., Nordberg, A., Bucht, G., and Winblad, B., 1986, Extraneural cholinergic markers in Alzheimer’s and Parkinson’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 247–257.
Amaral, D. G., and Kurz, J., 1985, An analysis of the origins of the cholinergic and non-cholinergic septal projections to the hippocampal formation for the rat, J. Comp. Neurol. 240: 37–59.
Ansell, G. B., and Spanner, S., 1979, Sources of choline for acetylcholine synthesis in the brain, in: Nutrition and the Brain, Vol. 5 ( A. Barbeau, J. H. Growden, and R. J. Wurtman, eds.), Raven Press, New York, pp. 35–46.
Arendt, A. U., Bigl, V., Arendt, A., and Tennstedt, A., 1983, Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff s disease, Acta Neuropathol. (Berlin) 61: 101–108.
Armstrong, D. M., Saper, C. B., Levay, A. I., Wainer, B. H., and Terry, R. D., 1983, Distribution of cholinergic neurons in rat brain: Demonstration by immunocytochemical localization of choline acetyltransferase, J. Comp. Neurol. 216: 53–68.
Armstrong, D. M., Bruce, G., Hersh, L. B., and Terry, R. D., 1986, Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain, Neurosci. Lett. 71: 229–234.
Aston-Jones, G., Shaver, R., and Dinan, T., 1984, Cortically projecting nucleus basalis neurons in rat are physiologically heterogeneous, Neurosci. Lett. 46: 19–24.
Aston-Jones, G., Shaver, R., and Dinan, T. G., 1985, Nucleus basalis neurons exhibit axonal branching with decreased impulse conduction velocity in rat cerebrocortex, Brain Res. 325: 271–285.
Atack, J. R., Perry, E. K., Bonham, J. R., Perry, R. H., Tomlinson, B. E., Blessed, G., and Fairbairn, A., 1983, Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: Selective loss of the intermediate (10S) form, Neurosci. Lett. 40: 199–204.
Atack, J. R., Perry, E. K., Perry, R. H., Wilson, I. D., Bober, M. J., Blessed, G., and Tomlinson, B. E., 1985, Blood acetyl- and butyrylcholinesterases in senile dementia of Alzheimer type, J. Neurol. Sci. 70: 1–12.
Baisden, R. H., Woodruff, M. L., and Hoover, D. B., 1984, Cholinergic and non-cholinergic septo-hippocampal projections: a double-label horseradish peroxidase-acetylcholinesterase study in the rabbit, Brain Res. 290: 146–151.
Bartus, R., Dean III, R. L., Beer, B., and Lippa, A. S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217: 408–417.
Beller, S. A., Overall, J. E., and Swann, A. C, 1985, Efficacy of oral physostigmine in primary degenerative dementia: A double-blind study of response to different dose level, Psychopharmacology 87: 147–151.
Ben-Barak, Y., Gazit, H., and Dudai, Y., 1980, Fornix lesion prevents an organophosp-hate-induced decrease in muscarinic receptor levels in rat hippocampus, Brain Res. 194: 249–253.
Berger, B., Verney, C, Gaspar, P., and Febvret, A., 1985, Transient expression of tyrosine hydroxylase immunoreactivity in some neurons of the rat neocortex during postnatal development, Dev. Brain Res. 23: 141–144.
Bigl, V., Woolf, N. J., and Butcher, L. L., 1982, Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis, Brain Res. Bull. 8: 727–749.
Birdsall, N. J. M., Burgen, A. S. V., and Hulme, E. C, 1978, The binding of agonists to brain muscarinic receptors, Mol. Pharmacol. 14: 723–736.
Bisso, G. M., Masullo, C, Michalek, H., Silveri, M. C, and Pocchiari, M., 1986, Molecular forms of cholinesterases in CSF of Alzheimer’s Disease/Senile Dementia of the Alzheimer type patients and matched neurological controls, Life Sci. 38: 561–567.
Blessed, G., Tomlinson, B. E., and Roth, M., 1968, The association between quantitative measures of dementia and of senile change in the cerebral gray matter of elderly subjects, Br. J. Psychiatry 114: 797–811.
Bolam, J. P., Ingham, C. A., Izzo, P. N., Levey, A. I., Rye, D. B., Smith, A. D., and Wainer, B. H., 1987, Substance P-containing terminals in synaptic contact with cholinergic neurons in the neostriatum and basal forebrain: A double immunocytochemical study in the rat, Brain Res. 397: 279–289.
Bouras, C, Guntern, R., and Constantinidis, J., 1985, Somatostatin in dementias of the Alzheimer type, in: Clinical and Pharmacological Studies in Psychiatric Disorders ( G. D. Burrows, T. R. Norman, and L. Dennerstein, eds.), John Libbey, London, pp. 295–305.
Bouras, C, De St. Hilaire-Kafi, S., and Constantinidis, J., 1986, Neuropeptides in Alzheimer’s disease: A review and morphological results, Prog. Neuro-Psychopharmacol. Bio. Psychiatry 10: 271–286.
Bowen, D. M., Smith, C. B., White, P., and Davidson, A. N., 1976, Neurotransmitter related enzymes and indixes of hypoxia in senile dementia and other abiotrophies, Brain, 99: 459–496.
Bowen, D. M., Benton, J. S., Spillane, J. A., Smith, C. C. T., and Allen, S. J., 1982, Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients, J. Neurol. Sci. 57: 191–202.
Bowen, D. M., Allen, S. J., Benton, J. S., Goodhardt, M. J., Haan, E. A., Palmer, A. M., Sims, N. R., Smith, C. C. T., Spillane, J. A., Esiri, M. M., Neary, D., Snowdon, J. S., Wilcock, G. K., and Davison, A. N., 1983, Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer’s disease, J. Neurochem. 41: 266–272.
Brinkman, S. D., and Gershon, S., 1983, Measurement of cholinergic drug effects on memory in Alzheimer’s disease, Neurobiol. Aging 4: 139–145.
Butcher, L. L., Talbot, K., and Bilezikjian, L., 1975, Acetylcholinesterase neurons in dopamine-containing regions of the brain, J. Neural Trans. 37: 127–153.
Candy, J. M., Perry, R. H., Perry, E. K., Irving, D., Blessed, G., Fairbairn, A. F., and Tomlinson, B. E., 1983, Pathological changes in the nucleus of Meynert in Alzheimer’s and Parkinson’s diseases, J. Neurol. Sci. 54: 277–289.
Carlsen, J., Zaborszky, L., and Heimer, L., 1985, Cholinergic projections from the basal forebrain to the basolateral amygdaloid complex: A combined retrograde fluorescent and immunohistochemical study, J. Comp. Neurol. 234: 155–167.
Casamenti, F., Deffenu, G., Abbamondi, A. L., and Pepeu, G., 1986, Changes in cortical acetylcholine output induced by modulation of the nucleus basalis, Brain Res. Bull. 16: 689–695.
Caulfield, M. P., Straughan, D. W., Cross, A.J., Crow, T., and Birdsall, N.J. M., 1982, Cortical muscarinic receptor subtypes and Alzheimer’s disease, Lancet 2: 1277.
Chipperfield, B., Newman, P. M., and Moyes, I. C. A., 1981, Decreased erythrocyte Cholinesterase activity in dementia, Lancet 2: 199.
Christie, J. E., Shering, A., Ferguson, J., and Glen, A. I. M., 1981, Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia, Br. J. Psychiatry 138: 46–50.
Clarke, P. B. S., Schwartz, R. D., Paul, S. M., Pert, C. B., and Pert, A. 1985, Nicotinic binding in rat brain: Autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [1251]alpha-bungarotoxin, J. Neurosci. 5: 1307–1315.
Collerton, D., 1986, Cholinergic function and intellectual decline in Alzheimer’s disease—Commentary, Neuroscience 19: 1–28.
Collier, B., and Mitchell, J. F., 1966, The central release of acetylcholine during stimulation of the visual pathway, J. Physiol. 184: 239–254.
Cortes, R., Probst, A., Tobler, H-J., and Palacios, J. M., 1986, Muscarinic cholinergic receptor subtypes in the human brain. II. Quantitative autoradiographic studies, Brain Res. 362: 239–253.
Coyle, J. T., 1982, Excitatory Amino Acid Neurotoxins, in: Handbook of Psychopharmacology, Vol. 15 ( L. L. Iversen, S. D. Iversen, and S. H. Snyder, eds.), Plenum Press, New York, pp. 237–269.
Coyle, J. T., Price, D. L., and Delong, M., 1983, Alzheimer’s Disease: A disorder of cortical cholinergic innervation, Science 219: 1184–1190.
Cross, A. J., Crow, T. J., Johnson, J. A., Perry, E. K., Perry, R. H., Blessed, G., and Tomlinson, B. E., 1984, Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer-type, J. Neurol. Sci. 64: 109–117.
Cross, A. J., Crow, T. J., Johnson, J. A., Perry, E. K., Perry, R. H., Blessed, G., and Tomlinson, B. E., 1984, Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer-type, J. Neurol. Sci. 64: 109–117.
Crow, T. J., Grove-White, I. G., and Kelman, G. R., 1971, Differential effect of atropine and hyoscine on human learning capacity, Br. J. Pharmacol. 43: 464.
Curtis, D. R., Ryall, R. W., and Waikins, J. C, 1965, Cholinergic transmission in the mammalian central nervous system, in: Cholinergic Mechanism ( P. G. Waser, ed.), Raven Press, New York, pp. 137–145.
Davies, P., 1979a, Biochemical changes in Alzheimer’s disease-senile dementia: neurotransmitters in senile dementia of the Alzheimer type, in: Congenital and Acquired Cognitive Disorders ( R. Katzman, ed.), Raven Press, New York, pp. 153–160.
Davies, P., 1979b, Neurotransmitter-related enzymes in senile dementia of the Alzheimer type, Brain Res. 171: 319–327.
Davies, P., and Maloney, A.J. F., 1976, Selective loss of cholinergic neurons in Alzheimer’s disease, Lancet 2: 1403.
Davies, P., and Reisullin, S., 1981, Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain, Brain Res. 216: 449–454.
Davies, P., and Verth, A. H., 1978, Regional distribution of muscarinic acetylcholine receptors in normal and Alzheimer’s type dementia brains, Brain Res. 138: 385–392.
Davies, P., Katzman, R., and Terry, R. D., 1980, Reduced somatostatin-like immunoreac-tivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementia, Nature 288: 279–280.
Davis, K. L., and Mohs, R. C, 1982, Enhancement of memory processes in Alzheimer’s disease with multiple-dose intravenous physostigmine, Am. J. Psychiatry 139: 1421–1424.
De Belleroche, J., Gardiner, I. M., Hamilton, M. H., and Birdsall, J. M., 1985, Analysis of muscarinic receptor concentration and subtypes following lesion of rat substantia innominata, Brain Res. 340: 201–209.
Dekosky, S. T., Scheff, S. W., and Markesbery, W. R., 1985, Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer’s disease and aging, Neurology 35: 1425–1431.
Delabar, J. M., Goldgaber, D., Lamour, Y., Nicole, A., Huret, J-L., Degrouchy, J., Brown, P., Gajdusek, C., and Sinet, P.-M. 1987, ß-amyloid gene duplication in Alzheimer’s Disease and karyotypically normal Down Syndrome, Science 235: 1390–1392.
Delima, A. D., and Singer, W., 1986, Cholinergic innervation of the cat striate cortex: A choline acetyltransferase immunocytochemical analysis, J. Comp. Neurol. 250: 324–338.
Delong, M. R., 1971, Activity of pallidal neurons during movement, J. Neurophys. 34: 414–427.
Deutsch, J. A., 1971, The cholinergic synapse and the site of memory, Science 174: 788–794.
Drachman, D. A., and Leavitt, J., 1974, Human memory and the cholinergic system: A relationship to aging? Arch. Neurol. 30: 113–121.
Drachman, D. A., and Sahakian, B. J., 1980, memory and cognitive function in the elderly, Arch. Neurol. 37: 674–675.
Dutar, P., Lamour, Y., Rascol, O., and Jobert, A., 1986a, Septo-hippocampal neurons in the rat: Further study of their physiological and pharmacological properties, Brain Res. 365: 325–334.
Dutar, P., Rascol, O., Jobert, A., and Lamour, Y., 1986b, Comparison of septo-hippocampal with basalo-cortical projection neurons in the rat: An electrophysiological approach, Neurosci. Lett. 63: 86–90.
Eckenstein, F., and Thoenen, H., 1983, Cholinergic neurons in the rat cerebral cortex demonstrated by immunohistochemical localization of choline acetyltransferase, Neurosci. Lett. 36: 211–215.
El-Defrawy, S. R., Boegman, R. J., Jhamandas, K., Beninger, R. J., and Shipton, L., 1986, Lack of recovery of cortical cholinergic function following quinolinic or ibotenic acid injections into the nucleus basalis magnocellularis in rats, Exp. Neurol. 91: 628–633.
Epelbaum, J., Lamour, Y., EnjalLamourbert, A., Hamon, M., Dutar, P., and Kordon, C, 1986, Modifications in the cortical regional distribution of choline acetyltransferase, somatostatin and somatostatin binding sites in the normal rat and following lesion of the nucleus basalis, Brain Res. 371: 376–379.
Feldberg, W., and Vogt, M., 1948, Acetylcholine synthesis in different regions of the nervous system, J Physiol. (London) 107: 372–381.
Fine, A., Dunnett, S. B., Bjorklund, A., and Iversen, S. D., 1985, Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease, Proc. Natl. Acad. Sci. USA 82: 5227–5230.
Fisher, R. S., Boylan, M. K., Hull, C. D., Buchwald, N. A., and Levine, M. S., 1985, Branched projections of pallidal and peripallidal neurons to neocortex and neostriatum: a double-labeling study in the cat, Brain Res. 326: 156–159.
Fonnum, F., 1970, Topographical and subcellular localization of choline acetyltransferase in the rat hippocampal region, J. Neurochem. 17: 1029–1037.
Foote, S. L., Freedman, R., and Oliver, A. P., 1975, Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex, Brain Res. 86: 229–242.
Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., Davison, A. N., Esiri, M. M., Neary, D., Snowden, J. S., Wilcock, G. K., 1985, Neurochemical studies of early-onset Alzheimer’s disease: Possible influence on treatment, N. Engl. J. Med. 313: 7–11.
Frotscher, M., and Leranth, C., 1985, Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: A combined light and electron microscopic study, J. Comp. Neurol. 239: 237–246.
Gage, F. H., and Bjorklund, A., 1986, Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism, J. Neurosci. 6: 2837–2847.
Gauthier, S., Robitaille, Y., Quirion, R., and Leblanc, R., 1986, Antemortem laboratory diagnosis of Alzheimer’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 391–403.
German, D. C, Bruce, G., and Hersh, L. B., 1985, Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyl-transferase, Neurosci. Lett. 61: 1–5.
Goldgaber, D., Lerman, M. I., Mcbride, O. W., Saffiotti, U., and Gajdusek, D. C, 1987, Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease, Science 235: 877–880.
Gower, A. J., 1986, Lesioning of the nucleus basalis in the rat as a model of Alzheimer’s disease, TIPS, Nov., pp. 432–434.
Greenfield, S., Cheramy, A., Leviel, V., and Glowinski, J., 1980, In vivo release of acetylcholinesterase in cat substantia nigra and caudate nucleus, Nature 284: 355–358.
Halliwell, J. V., and Adams, P. R., 1982, Voltage-clamp analysis of muscarinic excitation in hippocampal neurons, Brain Res. 250: 71–92.
Harbaugh, R. E., Roberts, D. W., Coombs, D. W., Saunders, R. L., and Reeder, T. M., 1984, Preliminary reports: Intracranial cholinergic drug infusion in patients with Alzheimer’s disease, Neurosurgery 15: 514–518.
Haroutunian, V., Kanof, P. D., and Davis, K. L., 1985, Pharmacological alleviation of cholinergic lesion induced memory deficits in rats, Life Sci. 37: 945–952.
Hartgraves, S. L., Mensah, P. L., and Keliv, P. H., 1982, Regional decreases of cortical choline acetyltransferase after lesions of the septal area and in the area of nucleus basalis magnocellularis, Neuroscience 7: 2369–2376.
Hebb, C. O., Krnjevic, K., and Silver, A., 1963, Effect of undercutting on the acetylcholinesterase and choline acetyltransferase activity in the cat cerebral cortex, Nature 198: 692–693.
Henke, H., and Lang, W., 1983, Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients, Brain Res. 267: 281–291.
Höhmann, C. F., Bear, M. F., and Ebner, F. F., 1985, Glutamic acid decarboxylase activity decreases in mouse neocortex after lesion of the basal forebrain, Brain Res. 333: 165–168.
Höhmann, C. F., Kitt, C. A., Wainer, B. H., Price, D. L., and Coyle, J. T., 1986, Distribution of ChAT immunoreactivity in the BALB/C mouse, Neurosci. Lett. Abstr. 26: 440.
Hoover, D. B., Muth, E. A., and Jacobowitz, D. M., 1978, A mapping of the distribution of acetylcholine, choline acetyltransferase and acetylcholinesterase in discrete areas of rat brain, Brain Res. 153: 295–306.
Houser, C. R., Crawfod, G. D., Salvaterra, P. M., and Vaughn, J. E., 1985, Immu-nocytochemical localization of choline acetyltransferase in rat cerebral cortex: A study of cholinergic neurons and synapses, J. Comp. Neurol. 234: 17–34.
Ichimiya, Y., Arai, H., Kosaka, K., and Iizuka, R., 1986, Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia, Acta Neuropathol. 70: 112–116.
Inoue, M., Oomura, Y., Nishino, H., Aou, S., Sikdar, S. K., Hynes, M., Mizuno, Y., and Katabuchi, T., 1983, Cholinergic role in monkey dorsolateral prefrontal cortex during bar-press feeding behavior, Brain Res. 278: 185–194.
Jacobowitz, D. M., and Creed, J., 1983, Cholinergic projection sites of the nucleus of tractus diagonalis, Brain Res. Bull. 10: 365–372.
Jenni-Eiermann, S., Von Hahn, H. P., Honegger, C. G., Ulrich, J., 1984, Studies on neurotransmitter binding in senile dementia, Gerontology 30: 350–358.
Johnston, M. V., Mckinney, M., and Coyle, J. T., 1979, Evidence for a cholinergic projection to neocortex from neurons in basal forebrain, Proc. Natl. Acad. Sci. USA 76: 5392–5396.
Johnston, M. V., Mckinney, M., and Coyle, J. T., 1981a, Neocortical cholinergic innervation: A description of extrinsic and intrinsic components in the rat, Exp. Brain Res. 43: 159–172.
Johnston, M. V., Young, A. C, and Coyle, J. T., 19816, Laminar distribution of cholinergic markers in neocortex: effects of lesions, J. Neurosci. Res. 6: 597–607.
Jones, E. G., Burton, H., Saper, C. B., and Swanson, L. W., 1976, Midbrain, diencephalic and cortical relationships of the basal nucleus of Meynert and associated structures in primates, J Comp. Neurol. 167: 385–398.
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K., and Muller-Hill, B., 1987, The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor, Nature 325: 733–736.
Karnovsky, M. J., and Roots, L., 1964, A “direct-coloring” thiocholine method for Cholinesterase, J Histochem. Cytochem. 12: 219–221.
Katzman, R., 1986, Medical progress—Alzheimer’s disease, N. Engl. J. Med. 314: 964–973.
Kay, D. W. K., Beamish, P., and Roth, M., 1964, Old-age mental disorders in Newcastel upon Tyne, I and II, Br. J. Psychiatry 110: 146–158, 668–682.
Kelly, J. S., Dodd, J., and Dingledine, R., 1979, Acetylcholine as an excitatory and inhibitory transmitter in the mammalian central nervous system, Prog. Brain Res. 49: 254–266.
Kimura, H., Mcgeer, P. L., Peng, J. H., and Mcgeer, E. G., 1981, The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat, J. Comp. Neurol. 200: 151–201.
Kitt, C. A., Price, D. L., Struble, R. G., Cork, L. C, Wainer, B. H., Becher, M. W., and Mobley, W. C, 1984, Evidence for cholinergic neuropathologies in senile plaques, Science 226: 1443–1445.
Kitt, C. A., Mitchell, S. J., Delong, M. R., Wainer, B. H., and Price, D. L., 1987, Fiber pathways of basal forebrain cholinergic neurons in monkeys, Brain Res. 406: 192–206.
Koelle, G., 1969, Significance of acetylcholinesterase in central synaptic transmission, Fed. Proc. 28: 95–100.
Koelle, G. B., and Friedenwald, J. S., 1949, A histochemical method for localizing Cholinesterase activity, Proc. Soc. Exp. Biol. Med. 70: 617–622.
Kohler, C, and Chan-Paley, V., 1983, Distribution of gamma aminobutyric acid containing neurons and terminals in the septal area, Anat. Embryol. 167: 53–65.
Kohler, C, Chan-Paley, V., and Wu, J.-Y., 1984, Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain, Anat. Embryol. 169: 41–44.
Krnjevic, 1974, Chemical nature of synaptic transmission in vertebrates, Physiol. Rev. 54: 418–465.
Krnjevic, K., and Phillis, J. W., 1963, Acetylcholine sensitive cells in cerebral cortex, J Physiol. (London) 166: 296–327.
Krnjevic, K., and Ropert, N., 1982, Electrophysiological and pharmacological characteristics of facilitation of hippocampal population spikes by stimulation of the medial septum, Neuroscience 7: 2165–2183.
Kuhar, M. J., 1976, The anatomy of cholinergic neurons, in: Biochemistry of Cholinergic Functions ( A. M. Goldberg and I. Hanin, eds.), Raven Press, New York, pp. 3–27.
Kuhar, M. J., and Yamamura, H. I., 1976, Localization of cholinergic muscarinic receptors in rat brain by light microscopic radioautography, Brain Res. 110: 229–243.
Lal, S., Wood, P. L., Kiely, M. E., Etienne, P., Gauthier, S., Stratford, J., Ford, R. M., Dastoor, D., and Nair, N. P. V., 1984, CSF acetylcholinesterase in dementia and in sequential samples of lumbar CSF, Neurobiol. Aging 5: 269–274.
Lamour, Y., Dutar, P., and Jobert, A., 1982a, Excitatory effect of acetylcholine on different types of neurons in the first somatosensory neocortex of the rat: Laminar distribution and pharmacological characteristics, Neuroscience 7: 1483–1494.
Lamour, Y., Dutar, P., and Jobert, A., 19826, Spread of acetylcholine sensitivity in the neocortex following lesion of the nucleus basalis, Brain Res. 252: 377–381.
Lamour, Y., Dutar, P., and Jobert, A., 1985, Effects of TRH, cyclo-(His-Pro) and (3-Me-His2) TRH on identified septohippocampal neurons in the rat, Brain Res. 331: 343–347.
Lamour, Y., Dutar, P., Rascol, O., and Jobert, A., 1986, Basal forebrain neurons projecting to the rat frontoparietal cortex: Electrophysiological and pharmacological properties, Brain Res. 362: 122–131.
Lang, W., and Henke, H., 1983, Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients, Brain Res. 267: 271–280.
Larsson, T., Sjogren, T., and Jacobson, G., 1963, Senile dementia, Acta Psychiatr. Scand. 167 (Suppl): 39.
Lehmann, J., Nagy, J. I., Atmadja, S., and Fibiger, H. C, 1980, The nucleus basalis magnocellularis: the origin of a cholinergic projection to the neocortex of the rat, Neuroscience 5: 1161–1174.
Lehmann, J., Struble, R. G., Antuono, P. G., Coyle, J. T., Cork, L. C, and Price, D. L., 1984, Regional heterogeneity of choline acetyltransferase activity in primate neocortex, Brain Res. 322: 361–364.
Lemann, W., and Saper, C. B., 1985, Evidence for a cortical projection to the magnocellular basal nucleus in the rat: an electron microscopic axonal transport study, Brain Res. 334: 339–343.
Levey, A. L., Wainer, B. H., Mufson, E. J., and Mesulam, M. M., 1983, Co-localization of acetylcholinesterase and choline-acetyltransferase in the rat cerebrum, Neuroscience 9: 9–22.
Levey, A. I., Wainer, B. H., Rye, D. B., Mufson, E. J., and Mesulam, M.-M., 1984, Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons, Neuroscience 13: 341–353.
Lewis, P. R., and Shute, C. C. D., 1967, The cholinergic limbic system: Projections to the hippocampal formation, medial cortex, nuclei of the ascending cholinergic reticular system and the subfornical organ and supraoptic crest, Brain Res. 90: 521–540.
London, E. D., Mckinney, M., Dam, M., Ellis, A., and Coyle, J. T., 1984, Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus, J Cerebral Blood Flow Metabol. 4: 381–390.
Lysakowski, A., Wainer, B. H., Rye, D. B., Bruce, G., and Hersh, L. B., 1986, Cholinergic innervation displays strikingly different laminar preferences in several cortical areas, Neurosci. Lett. 64: 102–108.
Marquis, J. K., Völliger, L., Direnfeld, L. K., and Freedman, M., 1984, Assays of Cholinesterase activity in plasma, erythrocytes and cerebrospinal fluid (CSF) of SDAT patients and normal controls, in: Alzheimers Disease: Advances in Basic Research and Therapies (R. J. Wurtman, S. H. Corkin, and J. H. Growson, eds.), Proceedings of the Third Meeting of the International Study Group on the Treatment of Memory Disorders associated with Aging, p. 458, Center for Brain Sciences and Metabolism, Charitable Trust, Zurich.
Mash, D. C, and Mesulam, M. M., 1986, Muscarine receptor distributions within architectonic subregions of the primate cortex, Soc. Neurosci. Abstr. 12: 809.
Mash, D. C, Glynn, D. D., and Potter, L. T., 1985, Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer’s disease and experimental cholinergic denervation, Science 228: 1115–1117.
Matthews, D. A., Salvaterra, P. M., Crawford, G. D., House, C. R., and Vaughn, J. E., 1987, An immunocytochemical study of choline acetyltransferase-containing neurons and axon terminals in normal and partially deafferented hippocampal formation, Brain Res. 402: 30–43.
Mccormick, D. A., and Prince, D. A., 1985, Two types of muscarinic response to acetylcholine in mammalian cortical neurons, Proc. Natl. Acad. Sci. USA 82: 6344–6348.
Mcgeer, P. L., Mcgeer, E. G., Singh, V. K., and Chase, W. H., 1974, Choline acetyltransferase localization in the central nervous system by immunocytochemistry, Brain Res. 81: 373–379.
Mcgeer, P. L., Mcgeer, E. G., Suzuki, J., Dolman, C. E., and Nagai, T., 1984, Aging Alzheimer’s disease, and the cholinergic system of the basal forebrain, Neurology 34: 741–745.
Mckinney, M., and Coyle, J. T., 1982, Regulation of neocortical muscarinic receptors: Effects of drug treatment and lesions, J. Neurosci. 2: 97–105.
Mckinney, M., Coyle, J. T., and Hedreen, J. C, 1983, Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system, J Comp. Neurol. 217: 103–121.
Meibach, R. C, and Siegel, A., 1977, Efferent connections of the hippocampal formation in the rat, Brain Res. 124: 197–224.
Mesulam, M-M., and Mufson, E. J., 1984, Neural inputs into the nucleus basalis of the substantia innominata (Ch4) in the rhesus monkey, Brain 107: 253–274.
Mesulam, M-M., Mufson, E. J., Levey, A. L, and Wainer, B. H., 1983, Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkey, J Comp. Neurol. 214: 170–197.
Mesulam, M-M., Mufson, E.J. Levey, A. I., and Wainer, B. H., 1984, Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry, Neuroscience 12: 669–686.
Mesulam, M. M., Volicer, L., Marquis, J. K., Mufson, E. J., and Green, R. C, 1986, Systematic Regional Differences in the cholinergic innervation of the primate cerebral cortex: Distribution of enzyme activities and some behavioral implications, Ann. Neurol. 19: 144–151.
Mitchell, S. J., Richardson, R. T., Baker, F. H., and Delong, M. R., 1983, Electrophysiological and functional characteristics of neurons in the nucleus basalis of Meynert in macaque monkeys, Soc. Neurosci. Abstr. 8: 212.
Mohs, R. C, Davis, K. L., and Levey, M. L., 1981, Partial reversal of anticholinergic amnesia by choline chloride, Life Sci. 29: 1317–1323.
Mohs, R. C, Davis, B. M., Johns, C. A., Mathe, A. A., Greenwald, B. S., Horvath, T. B., and Davis, K. L., 1985, Oral physostigmine treatment of patients with Alzheimer’s disease, Am. J. Psychiatry 142: 28–33.
Morrow, A. L., Loy, R., and Creese, L, 1983, Septal deafferentation increases hippocampal adrenergic receptors: Correlation with sympathetic axon sprouting, Proc. Natl. Acad. Sci. USA 80: 6718–6722.
Murray, C. L., and Fibiger, H. C, 1985, Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine, Neuroscience 14: 1025–1032.
Murray, C. L., and Fibiger, H. C, 1986, Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis, Behav. Neurosci. 100: 23–32.
Nagai, T., Kimura, H., Maeda, T., Mcgeer, P. L., Peng, F., and Mcgeer, E. G., 1982, Cholinergic projections from the basal forebrain of rat to the amygdala, J. Neurosci. 2: 513–520.
Nakamura, Y., Hassler, R., Kataoka, Y., Bak, I. J., and Kim, J. S., 1976, Regional distribution of choline acetyltransferase and acetylcholinesterase activity in baboon brain, Folia Psychiatri Neurol. Jpn. 30: 185–194.
Nakano, I., and Hirano, A., 1982, Loss of large neurons of the medial septal nucleus in an autopsy case of Alzheimer’s disease (abstract), J. Neuropathol. Exp. Neurol. 41: 341.
Nordberg, A., and Winblad, B., 1986, Brain nicotinic and muscarinic receptors in normal aging and dementia, in: Alzheimer’s and Parkinson’s Disease: Strategies for Research and Development ( A. Fisher, I. Hanin, and C. Lachman, eds), Plenum Press, New York, pp. 95–108.
Nordberg, A., Adolfsson, R., Marcusson, J., and Winblad, B., 1982, Cholinergic receptors in the hippocampus in normal aging and dementia of Alzheimer type, in: The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System, Vol. 20: Aging ( E. Giacobini, G. Filogram, G. Giacobini, and A. Vernadakis, eds.), Raven Press, New York, pp. 231–245.
Nordberg, A., Larsson, C, Adolfsson, R., Alafuzoff, I., and Winblad, B., 1983, Muscarinic receptor compensation in hippocampus of Alzheimer patients, J. Neural Transmiss. 56: 13–19.
Olton, D. S., Wenk, G. L., and Mos, R. C, 1987, Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system, in: Psychopharmacology: A Generation of Progress, Raven Press, New York.
Palacios, J. M., 1982, Autoradiographic localization of muscarinic cholinergic receptors in the hippocampus of patients with senile dementia, Brain Res. 243: 173–175.
Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C, Powell, T. P., Eckenstein, F., Esiri, M. M., and Wilcock, G. K., 1983, Persistance of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer’s type demonstrated by immunohisto-chemical staining for choline acetyltransferase, Brain Res. 289: 375–379.
Pedata, F., Lo Conte, G., Sorbi, S., Pepeu, I. M., and Pepeu, G., 1982, Changes in high affinity choline uptake in rat cortex following lesions of the magnocellular forebrain nuclei, Brain Res. 233: 359–367.
Pepeu, G., Casamenti, F., Pedata, F., Cosi, C, and Pepeu, I. M., 1986, Are the neurochemical and behavioural changes induced by lesins of the nucleus basalis in the rat a model of Alzheimer’s disease? Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 541–551.
Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., and Tomlinson, B. E., 1977a, Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue, J. Neurol. Sci. 34: 247–265.
Perry, E. K., Perry, R. H., Blessed, G., and Tomlinson, B. E., 1977b, Necropsy evidence of central cholinergic deficits in senile dementia (letter to the ed.), Lancet 1:189.
Perry, E. K., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P. H., and Perry, R. H., 1978, Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Br. Med. J. 2: 1457–1459.
Perry, E. K., Blessed, G., Tomlinson, B. E., Perry, R. H., Crow, T. J., Cross, A. J., Dockray, G. J., Dimaline, R., and Arregui, A., 1981, Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes, Neurobiol. Aging 2: 251–256.
Perry, R. H., Candy, J. M., Perry, E. K., Irving, D., Blessed, G., Fairbairn, A. F., and Tomlinson, B. E., 1982, Extensive loss of choline acetylransferase activity is not reflected by neuronal loss in the nucleus of Meynert in Alzheimer’s disease, Neurosci. Lett. 33: 311–315.
Perry, E. K., Atack, J. R., Perry, R. H., Hardy, J. A., Dodd, P. R., Edwardson, J. A., Blessed, G., Tomlinson, B. E., and Fairbairn, A. F., 1984, Intralaminar neurochemical distributions in human mid tempo ral cortex: Comparison between Alzheimer’s disease and the normal, J. Neurochem. 42: 1402–1410.
Phillis, J. W., 1968, Acetylcholine release from the cerebral cortex: Its role in cortical arousal, Brain Res. 7: 378–389.
Pomara, N., Bagne, C. A., Stanley, M., and Yarbrough, G. G., 1986, Prospective strategies for cholinergic interventions in Alzheimer’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 553–569.
Pope, A., Hess, H. H., and Levin, E., 1965, Neurochemical pathology of the cerebral cortex in presenile dementias, Trans. Am. Neurol. Assoc. 89: 15–16.
Potter, L. T., Flynn, D. D., Hanchett, H. E., Kalinoski, D. L., Luber-Narod, J., and Mash, D. C, 1984, Independent Ml and M2 receptors: Ligands, autoradiography and functions, Trends Pharmacol. Sci. l (Suppl): 22–31.
Price, J. L., and Stern, R., 1983, Individual cells in the nucleus basalis-diagonal band complex have restricted axonal projections to the cerebral cortex in the rat, Brain Res. 269: 352–356.
Prusky, G., and Cynader, M., 1986, The distribution of muscarinic and nicotinic acetyl-cholinergic binding sites in the developing cat visual cortex, Soc. Neurosci. Abstr. 12: 1372.
Quirion, R., Richard, J., Dam, T. V., 1985, Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex, Brain Res. 333: 345–349.
Reisine, T. D., Yamamura, H. I., Bird, E. D., and Enna, S. J., 1978, Pre- and postsynaptic neurochemical alternatives in Alzheimer’s disease, Brain Res. 159: 477–481.
Richardson, R. T., and Delong, M. R., 1986, Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey, Brain Res. 399: 364–368.
Richter, J. A., Perry, B. K., and Tomlinson, B. E., 1980, Acetylcholine and choline levels in postmortem human brain tissue: preliminary observations in Alzheimer’s disease, Life Sci. 26: 1680–1689.
Rigdon, G. C, and Prich, J. H., 1986, Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex, J. Neurosci. 6: 2535–2542.
Rinne, J. O., Rinne, J. K., Laakso, K., Paijarvi, Rinne, U. K., 1984, Reduction in muscarinic receptor binding in limbic areas of Alzheimer brain, J. Neurol. Neurosurg. Psychiatry 47: 651–653.
Rinne, J. O., Laakso, K., Lonnberg, P., Molsa, P., Paljarvi, L., Rinne, J. K., Sako, E., and Rinne, U. K., 1985, Brain muscarinic receptors in senile dementia, Brain Res. 336: 19–25.
Rogers, J., and Morrison, J. G., 1985, Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer’s Disease, J. Neurosci. 5: 2801–2808.
Rolls, E. T., Sanghera, M. K., and Roper-Hall, A., 1979, The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey, Brain Res. 164: 121–135.
Rosenberg, G. S., and Davis, K. L., 1982, The use of cholinergic precursors in neuropsychiatric diseases, Am. J. Clin. Nutri. 36: 709–720.
Rossier, J., 1977, Choline acetyltransferase: A review with special reference to its cellular and subcellular localization, Int. Rev. Neurobiol. 20: 283–337.
Rossor, M. N., Garrett, N.J., Johnson, A. L., Mountjoy, C. Q., Roth, M., and Iversen, L L., 1982a, A post-mortem study of cholinergic and GAB A systems in senile dementia, Brain 10: 313–339.
Rossor, M. N., Svendsen, C, Hunt, S. P., Mountjoy, C. Q., Roth, M., and Iversen, L. L., 1982b, The substantia innominata in Alzheimer’s disease: A histochemical and biochemical study of cholinergic marker enzymes, Neurosci. Lett. 28: 217–222.
Rossor, M. N., Iversen, L. L., Reynolds, G. P., Mountjoy, C. Q., and Roth, M., 1984, Neurochemical characteristics of early and late onset types of Alzheimer’s disease, Br. Med. J. 288: 961–964.
Roth, M., Tomlinson, B. E., and Blessed, G., 1967, The relationship between measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects, Proc. R. Soc. Med. 60: 254–259.
Rotter, A., Birdsall, N.J. M., Burgen, A. S. V., Field, P. M., Hulme, E. C., and Raisman, G., 1979, Muscarinic receptors in the central nervous system of the rat. I. Technique for autoradiographic localization of the binding of [3H]propylbenzilylcholine mustard and its distribution in the forebrain, Brain Res. Rev. 1: 141–165.
Rye, D. B., Wainer, B. H., Mesulam, M.-M., Mufson, E. J., and Saper, C. B., 1984, Cortical projections arising from the basal forebrain: study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase, Neuroscience 13: 627–643.
Rylett, R. G., Ball, M. J., and Colhoun, E. H., 1983, Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer’s disease, Brain Res. 289: 169–175.
Saper, C. B., 1984, Organization of cerebral cortical afferent systems in the rat. II. Magno-cellular basal nucleus, J. Comp. Neurol. 222: 313–342.
Saper, C. B., German, D. C, and White, C. L. III, 1985, Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer’s type: possible role in cell loss, Neurology 35: 1089–1095.
Schwartz, A. S., and Kohlstaedt, E. V., 1986, Physostigmine effects in Alzheimer’s disease: Relationship to dementia severity, Life Sci. 38: 1021–1028.
Sethy, V. M., Kuhar, M. J., Roth, R. H., Van Woert, H. H., Aghajaniau, G. K., 1973, Cholinergic neurons: Effect of acute septal lesion on ACh and Ch content of rat hippocampus, Brain Res. 55: 681–686.
Shimohama, S., Taniguchi, T., Fujiwara, M., and Kameyama, M., 1986, Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia, J. Neurochem. 46: 288–293.
Shute, C. C. D., and Lewis, P. R., 1967, The ascending cholinergic reticular system: Neocortical, olfactory and subcortical projections, Brain 90: 497–520.
Silitto, A. M., and Kemp, J. A., 1983, Cholinergic modulation of the functional organization of the cat visual cortex, Brain Res. 289: 143–155.
Sims, N. R., Bowen, D. M., Smith, C. C, Flack, R. H., Davison, A. N., Snowden, J. S., and Neary, D., 1980, Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer’s disease, Lancet 1: 333–336.
Sims, N. R., Bowen, D. M., Allen, S. J., Smith, LI., Neary, D., Thomas, D. J., and Davison, A. W., 1983, Presynaptic cholinergic dysfunction in patients with dementia, J. Neurochem. 40: 503–509.
Sitaram, N., Weingartner, H., Caine, E. D., and Gillin, J. C., 1978, Choline: selective enhancement of serial learning and encoding of low imagery words in man, Life Sci. 22: 1555–1560.
Smith, R. C, Ho, B. T., Hus, L., Vroulis, G., and Claghorm, J., 1982, Cholinesterase enzymes in the blood of patients with Alzheimer’s disease, Life Sci. 30: 543–546.
Sofroniew, M. V., Eckenstein, F., Thoenin, H., and Cuello, A. C, 1982, Topography of choline acetyltransferase-containing neurons in the forebrain of the rat, Neurosci. Lett. 33: 7–12.
Soininen, H., Halonen, T., and Riekkinen, P. J., 1981, Acetylcholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type, Acta Neurol. Scand. 64: 217–224.
Spehlman, R., and Smathers, C. C, 1974, The effects of acetylcholine and of synaptic stimulation on the sensorimotor cortex of cats. II. Comparison of the neuronal responses to reticular and other stimuli, Brain Res. 74: 243–253.
Spokes, E. G. S., 1979, An analysis of factors influencing measurements of dopamine, noradrenaline, glutamic acid decarboxylase and choline acetylase in human post-mortem brain, Brain 102: 333–346.
St. George-Hyslop, P., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L., Watkins, P. C, Myers, R. H., Feldman, R. G., Pollen, D., Drachman, D., Growdon, J., Bruni, A., Foncin, J.-F., Salmon, D., Frommelt, P., Amaducci, L., Sorbi, S., Piacentini, S., Stewart, G. K., Hobbs, W. J., Conneally, M., and Gusella, J. F., 1987, The genetic defect causing familial Alzheimer’s Disease maps on chromosome 21, Science 235: 885–889.
Stone, T. W., 1972, Cholinergic mechanisms in the rat somatosensory cerebral cortex, J. Physiol. (London) 225: 485–489.
Storm-Mathisen, J., 1974, Choline-acetyltransferase and acetylcholinesterase in the fascia dentata following lesions of the entorhimal afferents, Brain Res. 80: 181–197.
Struble, R. G., Cork, L. C, Whitehouse, P. J., and Price, D. L., 1982, Cholinergic innervation in neuritic plaques, Science 216: 413–415.
Summers, W. K., Majovski, L. V., Marsh, G. M., Tachiki, K., and Kling, A., 1986, Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type, N. Engl. J. Med. 315: 1241–1287.
Sunderland, T., Tariot, P., Murphy, D. L., Weingartner, H., Mueller, E. A., and Cohen, R. M., 1985, Scopolamine challenges in Alzheimer’s Disease, Psychopharmacology 87: 247–249.
Swanson, L. W. and Cowan, W. M., 1977, An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat, J. Comp. Neurol. 172: 49–84.
Tagliavini, F., and Pilleri, G., 1983, Neuronal counts in basal nucleus of Meynert in Alzheimer’s disease and in simple senile dementia, Lancet 1: 469–470.
Tanzi, R. E., Gusella, J. F., Watkins, P. C, Bruns, G. A. P., St. George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., and Neve, R. L., 1987, Amyloid ß protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus, Science 235: 880–883.
Thal, L. J., Fuld, P. A., Masur, D. M., and Sharpless, N. S., 1983, Oral physostigmine and lecithin improve memory in Alzheimer disease, Ann. Neurol. 13: 491–496.
Thal, L. J., Masur, D. M., Sharpless, N. S., Fuld, P. A., and Davies, P., 1986, Acute and chronic effects of oral physostigmine and lecithin in Alzheimer’s disease, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 627–636.
Tune, L., Gucker, S., Folstein, M., Oshida, L., and Coyle, J. T., 1985, Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type, Ann. Neurol. 17: 46–48.
Vincent, S. R., Saioh, K., and Fibiger, H. C, 1986, The localization of central cholinergic neurones, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 10: 637–656.
Wainer, B. H., Bolam, J. P., Freund, T. F., Henerson, Z., Totterdell, S., and Smith, A. D., 1984, Cholinergic synapses in the rat brain: a correlated light and electron microscopic immunohistochemical study employing a monoclonal antibody against choline acetyltransferase, Brain Res. 308: 69–76.
Walker, L. C, Kitt, C. A., Delong, M. R., and Price, D. L., 1985, Noncollateral projections of basal forebrain neurons to frontal and parietal neocortex in primates, Brain Res. Bull. 15: 307–314.
Walker, L. C, Brizzee, K. R., Kaack, M. B., and Price, D. L., 1986, Choline acetyltransferase and acetylcholinesterase activities in neocortex and hippocampus of squirrel monkey (Saimiri sciureus), Am. J. Primatol. 11: 195–210.
Wamsley, J. K., Zarbin, M. A., Birdsall, N.J. M., and Kuhar, M. J., 1980, Muscarinic cholinergic receptors: autoradiographic localization of high and low affinity agonist binding sites, Brain Res. 200: 1–12.
Watson, M., Vickroy, T. W., Fibiger, H. C, Roeske, W. R., and Yamamura, H. I., 1985, Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex, Brain Res. 346: 387–391.
Wenk, G. L., and Engisch, K. L., 1986, [3H]Ketanserin (Serotonin Type 2) binding increases in rat cortex following basal forebrain lesions with ibotenic acid, J. Neurochem. 47: 845–849.
Wenk, G. L., Hughey, D. J., and Olton, D. S., 1987, Basal forebrain cholinergic neurons and Alzheimer’s disease, in: Animal Models of Dementia: A Synaptic Neurochemical Perspective, Vol. 3, Neurology and Neurobiology ( J. T. Coyle, ed.), pp. 81 - 101, Alan R. Liss, New York.
Wenk, H., Bigl, V., and Meyer, U., 1980, Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats, Brain Res. Rev. 2: 296–316.
Wettstein, A., and Spiegel, R., 1984, Clinical trials with the cholinergic drug RS 86 in Alzheimer’s disease (AD) and senile dementia of the Alzheimer type (SDAT), Psychopharmacology 84: 572–573.
Whitacker, V. P., and Sheridan, M. N., 1965, The morphology and acetylcholine content of isolated cerebral cortical synaptic vesicles, J. Neurochem. 12: 363–372.
White, P., Goodhardt, M. J., Keet, J. P., Hiley, C. R., Carrasco, L. H., Williams, I. E. I., and Bowen, D. M., 1977, Neocortical cholinergic neurons in elderly people, Lancet 1: 668–670.
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., and Delong, M. R., 1981, Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol. 10: 122–126.
Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and Delong, M. R., 1982, Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain, Science 215: 1237–1239.
Whitehouse, P. J., Kopajtic, T., Jones, B. E., Kuhar, M. J., and Price, D. L., 1985, An in vitro receptor autoradiographic study of muscarinic cholinergic receptor subtypes in the amygdala and neocortex of patients with Alzheimer’s disease, Neurology 35 (Suppl 1): 217.
Whitehouse, P. J., Martino, A. M., Antuono, P. G., Lowenstein, P. R., Coyle, J. T., Price, D. L., Kellar, K.J., 1986, Nicotinic acetylcholine binding in Alzheimer’s disease, Brain Res. 371: 146–151.
Wieraszko, A. B., Oderfeld-Nowak, B., and Narkiewicz, O., 1977, Ipsi and contralateral changes in acetylcholinesterase and choline acetyltransferase activities in hippocampus following unilateral septal lesions in the rat, Neuroscience 2: 649–654.
Wilcock, G. K., Esiri, M. M., Bowen, D. M., and Smith, C. C, 1982, Alzheimer’s disease: Correlation of cortical choline acetyltransferase activity with the severity of dementia and histologic abnormalities, J. Neurol. 57: 407–417.
Wilcock, G. K., Esiri, M. M., Bowen, D. M., and Smith, C. C, 1983, The nucleus basalis in Alzheimer disease, cell counts and cortical biochemistry, Neuropathol. Appl. Neurobiol. 9: 175–179.
Wood, P. L. Etienne, P., Lal, S., Nair, N. P. V., Finlayson, M. H., Gautheir, S., Palo, J., Haltia, M., Paetau, A., Bird, E. D., 1983, A post-mortem comparison of the cortical cholinergic system in Alzheimer’s disease and Pick’s disease, J. Neurol. Sci. 62: 211–217.
Woolf, N.J., Eckenstein, F., and Butcher, L. L., 1983, Cholinergic projections revealed by choline acetyltransferase (ChAT) immunohistochemistry and fluorescent tracer histology performed on the same tissue section, Soc. Neurosci. Abstr. 9: 967.
Yamamura, H. I., and Snyder, S. H., 1974, Muscarinic cholinergic binding in rat brain, Proc. Natl. Acad. Sci USA 71: 1725–1729.
Yamamura, H. I., Kuhar, M. J., Greenberg, D., and Snyder, S. H., 1974, Muscarinic cholinergic receptor binding: regional distribution in monkey brain, Brain Res. 66: 541–546.
Zaczek, R., Hedreen, J. C. and Coyle, J. T., 1979, Evidence for a hippocampal-septal glutamatergic pathway in the rat, Exp. Neurol. 65: 145–156.
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Höhmann, C., Antuono, P., Coyle, J.T. (1988). Basal Forebrain Cholinergic Neurons and Alzheimer’s Disease. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0933-8_2
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