Abstract
Methylguanidine (MG) has been implicated as a potent uremic toxin1–3. Furthermore, the carcinogenecity of the nitrosated compound, MG, has been reported4. Chemically, MG is an oxidative product which results from the exposure of creatinine (CRN) to silver, mercury, copper, Fe3+ or charcoal5. However the factors affecting the oxidation of CRN to MG are far different from the internal environment of uremics, and the mechanism of its synthesis in vivo still remains unclear. We have reported MG synthesis in various tissues of rats and also have shown MG synthesis in liver using isolated hepatocytes6.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Giovannetti, S., Biagini, M., Balestri, P. L., Navasesi, R., Giagnoni, P., deMatteis, A., Ferro-Milone, P. and Perfetti, C., Uremia-like syndrome in dogs chronically intoxicated with me thylguanidine and creatinine, Clin. Sci. 36 (1969) 445–452.
Giovannetti, S., Balestri, P. L. and Barsotti, G., Methylguanidine in uremia, Arch. Intern. Med. 131 (1973) 709–713
Barsotti, G., Bevilacqua, G., Morelli, E., Cappelli, P., Balestri, P. L. and Giovannetti, S., Toxicity arising from guanidine compounds: Role of methylguanidine as a uremic toxin, Kidney Int. 7 (1975) S299–S301.
Endo, G. and Takahashi, K., Identification and property of the mutagenic principle formed from a food-component, methylguanidine, after nitrosation in simulated gastric juice, Biochem. Biophys. Res. Commun. 54 (1973) 1384–1392.
Baumann, L. and Ingvalden, T., An oxidation product of creatinines J. Biol. Chem. 36 (1918) 277–280.
Nagase, S., Aoyagi, K., Narita, M. and Tojo, S., Biosynthesis of methylguanidine in isolated rat hepatocytes and in vivo. Nephron 40 (1985) 470–475.
Nagase, S., Aoyagi, K., Narita, M. and Tojo, S., Stimulatory and inhibitory factors of methylguanidine synthesis in rat organs, Jpn. J. Nephrol. 27 (1985) 1141–1147.
Nagase, S., Aoyagi, K., Narita, M. and Tojo, S., Synthesis of methylguanidine by active oxygen, with special reference to the signifcant role of hydroxy1 radical, Jpn. J. Nephro. 27 (1985) 1149–1159.
Berry, M. N. and Friend, D. S., High-yield preparation of isolated liver cells, J. Cell Biol. 43 (1969) 506–520.
Aoyagi, K., Ohba, S., Narita, M. and Tojo, S., Regulation of biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes and in vivo, Kidney Int. 24 (1983) S224–S228.
Zahlten, R. N., Stratman, F. W. and Lardy, H. A., Regulation of glucose synthesis in hormone-sensitive isolated rat hepatocytes, Proc. Natl. Acad, Sci. USA 70 (1973) 3213–3218.
Paller, M. S., Free radical scanvengers in mercuric chloride-induced aciite renal failure in the rat, J. Lab. Clin. Med. 28 (1985) 459–463.
Halliwll, B. and Gutteridge, J. M. C., Oxygen toxicity, oxygen radicals, transition metals and disease, Biochem. J. 219 (1984) 1–14.
Orrenius, S., Thor, H., Belloma, G. and Moldeus, P., Glutathione and tissue toxicity, in: “Proceedings of Iuphar 9th international congress of pharmacology, volume 2”, S. W. Paton, J. Mitchell and P. Turner Eds., The Macmillan Press Ltd, Houndmills, Hampshire (1984) pp. 57.
Halliwell, B. and Foyer, C.H., Ascorbic acid, metal ions and the superoxide radical, Biochem. J. 155 (1976) 697–700.
Aoyagi, K., Ohba, S. and Nagase, S. Mechanism of synthesis of guanidino compound, Jpn. J. Nephrolo. 27 (1985) 1034–1036.
Aoyagi, K., Narita, M. and Tojo, S., Uremic toxin: recent progress of our study, Medical Practice vol. 3 No2. (1986) 256–259.
Aoyagi, K., Nagase, S., Narita, M. and Tojo, S., Role of active oxygen on methylguanidine synthesis in isolated rat hepatocytes, Kidney Int. (in press)
Hollunger, G., Guanidines and oxidative phosphorylations, Acta pharmacol. Toxicol. 11 Supl. (1955) 1–84.
Hiramatsu, M., Edamatsu R., Kohno, M. and Mori, A., Proc. Annual Meeting Jpn. Guanidino Compound Res. Assoc. 9 (1986) 44–45.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Aoyagi, K., Nagase, S., Sakamoto, M., Narita, M., Tojo, S. (1989). Active Oxygen in Methylguanidine Synthesis by Isolated Rat Hepatocytes. In: Mori, A., Cohen, B.D., Koide, H. (eds) Guanidines 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0821-8_10
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0821-8_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8099-6
Online ISBN: 978-1-4613-0821-8
eBook Packages: Springer Book Archive