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Guanidines 2

Further Explorations of the Biological and Clinical Significance of Guanidino Compounds

  • Akitane Mori
  • Burton D. Cohen
  • Hikaru Koide

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Analytical Method for Guanidino Compounds and New Guanidino Compounds

    1. Front Matter
      Pages 1-1
    2. Moto-o Nakajima, Kazuo Nakamura, Yoshio Shirokane, Yoshihei Hirasawa
      Pages 3-11
    3. Katsuo Haruki, Shuichi Hatakeyama, Masayoshi Hirata, Hiroaki Muramoto, Yohei Tofuku, Ryoyu Takeda
      Pages 13-14
  3. Metabolism of Guanidino Compounds

    1. Front Matter
      Pages 33-33
    2. Ijaz A. Qureshi, Bart Marescau, Maurice Levy, Peter P. De Deyn, Jacques Letarte, Armand Lowenthal
      Pages 45-51
    3. Yoko Watanabe, Isao Yokoi, Akitane Mori
      Pages 53-60
    4. Myron D. Gross, Alexander M. Simon, Richard J. Jenny, Ernest D. Gray, Denise M. McGuire, John F. Van Pilsum
      Pages 61-69
    5. Kazumasa Aoyagi, Sohji Nagase, Masako Sakamoto, Mitsuharu Narita, Shizuo Tojo
      Pages 79-85
    6. Masako Sakamoto, Kazumasa Aoyagi, Sohji Nagase, Shoji Ohba, Mitsuhiro Miyazaki, Mitsuharu Narita et al.
      Pages 87-95
    7. Midori Hiramatsu, Rei Edamatsu, Masahiro Kohno, Akitane Mori
      Pages 97-105
  4. Physiological, Pharmacological and Toxicological Aspects of Guanidino Compounds

    1. Front Matter
      Pages 107-107
    2. Burton D. Cohen
      Pages 109-113
    3. Katsuya Nagai, Akiko Hashida, Hachiro Nakagawa
      Pages 115-122
    4. Michio Kitaura, Yoji Ochiai, Seiji Sugimoto, Koji Kabutan, Yoshinori Kosogabe, Chiaki Tsuji et al.
      Pages 129-134
    5. Masayoshi Hirata, Shuichi Hatakeyama, Katsuo Haruki, Hiroaki Muramoto, Yohei Tofuku, Ryoyu Takeda
      Pages 135-136
    6. Yoshiyuki Takano, Fumitake Gejyo, Yoshio Shirokane, Moto-o Nakajima, Masaaki Arakawa
      Pages 137-146
    7. Seiji Sugimoto, Yoji Ochiai, Michio Kitaura, Koji Kabutan, Chiaki Tsuji, Yoshinori Kosogabe et al.
      Pages 147-151
    8. Hideki Sugi, Isao Yokoi, Yoko Watanabe, Akitane Mori
      Pages 159-164
  5. Involvement of Seizure Mechanism

    1. Front Matter
      Pages 167-167
    2. Isao Yokoi, Akira Edaki, Yoko Watanabe, Yoshihisa Shimizu, Hiroko Toda, Akitane Mori
      Pages 169-181
    3. Shoichiro Shindo, Douglas W. Bonhaus, Ryan J. Huxtable
      Pages 183-187
    4. Ryan J. Huxtable, Anders Lehmann, Mats Sandberg, Shoichiro Shindo
      Pages 189-197
    5. Peter Wiecherf, Bart Marescau, Peter P. De Deyn, Luth Van Gorp, Werner P. De Potter, Armand Lowenthal
      Pages 199-202
    6. Bart Marescau, Peter P. De Deyn, Lut Van Gorp, Werner P. De Potter, Armand Lowenthal, Peter Wiechert et al.
      Pages 203-212
  6. Hyperargininemia

    1. Front Matter
      Pages 223-223
    2. Armand Lowenthal, Bart Marescau
      Pages 225-231
    3. Naoki Mizutani, Chiemi Hayakawa, Yukihiro Oya, Kazuyoshi Watanabe, Yoko Watanabe, Akitane Mori
      Pages 233-243
    4. Bart Marescau, Ijaz A. Qureshi, Peter P. De Deyn, Jacques Letarte, Nestor Chamoles, Makoto Yoshino et al.
      Pages 245-249
    5. Peter P. De Deyn, Robert L. Macdonald, Bart Marescau, Armand Lowenthal
      Pages 251-257
  7. Involvement of Giuanidino Compounds in Renal Dysfunction

    1. Front Matter
      Pages 259-259
    2. Yasushi Suzuki, Fumitake Gejyo, Masaaki Arakawa
      Pages 261-265
    3. Sohji Nagase, Kazumasa Aoyagi, Masako Sakamoto, Mitsuhiro Miyazaki, Shoji Ohba, Mitsuharu Narita et al.
      Pages 267-275
    4. Masato Inouchi, Tomoya Fujino, Takeo Sato, Takashi Yasuda, Hitoshi Tomita, Tsukasa Kanazawa et al.
      Pages 277-288
    5. Makoto Ishizaki, Hiroshi Kitamura, Hisako Sugai, Kazuyuki Suzuki, Kosei Kurosawa, Gen Futaki et al.
      Pages 289-297
    6. Burton D. Cohen, Harini Patel
      Pages 299-301
    7. Shuei Nakayama, Masahiro Junen, Ikuo Kiyatake, Hikaru Koide
      Pages 303-311
    8. Shuei Nakayama, Ikuo Kiyatake, Yoshio Shirokane, Hikaru Koide
      Pages 313-322
    9. Kazuyuki Tasaki, Kazukiyo Yoshida, Fumitake Gejyo, Masaaki Arakawa
      Pages 323-329
    10. Yoshiharu Tsubakihara, Eiji Yamato, Kenji Yokoyama, Eisaku Kitamura, Noriyuki Okada, Isao Nakanishi et al.
      Pages 331-336
    11. Kazuo Isoda, Tetsuya Mitarai, Noritsugu Imamura, Hidehiko Honda, Ryoji Nagasawa, Satoru Hirose et al.
      Pages 337-344
  8. Back Matter
    Pages 345-365

About this book

Introduction

Guanidine is named for its similarity to the purine guanine which, in turn, is named for its principal source guano, which comes from the Inca word, huano, for dung. Guanidine, therefore, translates into dung-like, which is hardly a genteel way to introduce a subject. On the other hand, texts are seldom inspirational, "frequently crude and rarely literary and should be judged on how successfully they assemble, organize and present current data. I am impressed that the material which fol]ows goes a long way toward successfully achieving those goals. Tue International Guanidine Society is a synthesis of three groups of investigators: biologists studying guanidines as phosphagens, neurologists interested in guanidines as convulsants and nephrologists involved with guanidines as toxins. As a member of the latter group. I am gratified by the considerable progress this book represents. To begin with. there now appears to be a common theme which unifies current speculation concerning the metabolic origin of the guanidines in uremia. At the First International Congress in 1983, evidence was presented which supported the theory that certain guanidines were products of the mixed function oxidation of urea. This year's meeting brings together overwhelming data showing that methyl guanidine is an effect of active oxygen reacting with creatinine. An idolatry, worshipped throughout biochemistry, that urea and creatinine are inert byproducts of protein metabolism, is shown to have feet of clay.

Keywords

Oxidation Toxin biochemistry chemistry plants

Editors and affiliations

  • Akitane Mori
    • 1
  • Burton D. Cohen
    • 2
  • Hikaru Koide
    • 3
  1. 1.Okayama University Medical SchoolOkayamaJapan
  2. 2.The Bronx Lebanon Hospital CenterBronxUSA
  3. 3.Juntendo University School of MedicineTokyoJapan

Bibliographic information