Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation

  • T. J. Collier
  • D. E. RedmondJr.
  • R. H. Roth
  • J. D. Elsworth
  • J. R. SladekJr.

Abstract

The motor abnormalities and progressive debilitation associated with Parkinson’s disease has been linked to depletion of the neurotransmitter dopamine in the nigrostriatal system of the brain (12). Supplementation of brain dopamine by administration of the precursor substance L-dopa significantly improves the motor symptoms of the disease, and has been the preferred treatment for the past 20 years (16). However, chronic L-dopa administration often yields negative side-effects (3), and the benefit of the drug diminishes as the disease progresses (7,24).

Keywords

Dopamine Tyrosine Neurol Catecholamine Tated 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • T. J. Collier
    • 1
  • D. E. RedmondJr.
    • 2
  • R. H. Roth
    • 3
  • J. D. Elsworth
    • 3
  • J. R. SladekJr.
    • 1
  1. 1.Department of Neurobiology and AnatomyUniversity of Rochester School of MedicineRochesterUSA
  2. 2.Departments of PsychiatryYale University School of MedicineNew HavenUSA
  3. 3.Departments of PharmacologyYale University School of MedicineNew HavenUSA

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