Abstract
Blastokinin (1) or uteroglobin (UG; 2) is a secretory protein with a low molecular mass (15.8 kDa). This protein was originally discovered in the rabbit uterine fluid during early pregnancy (1, 2). Its synthesis and secretion in the endometrium are stimulated by progesterone (2–5). Since its discovery in 1967, UG has been one of the most thoroughly studied markers of progesterone action in the rabbit endometrium. In addition to the uterus, UG has been found in several other organs of rabbits, namely, the oviduct, the male genital tract and the tracheobronchial tree of both male and female animals (4–9). More recently, we detected UG in the circulation of the rabbit (10). The source of this protein in circulation seems to be the tracheobronchial epithelium and/or the progesterone-induced uterine endometrium (10).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Krishnan, R.S., and Daniel, Jr. J.C. 1967 Science 158: 490.
Beier, H.M. 1969 Biochem Biophys. Acta 160: 289.
Arthur, A.T., and Daniel, Jr. J.C. 1972. Fertil. Steril. 23: 115.
Kay, E., and Feigelson, M. 1974. Biochem. Biophys. Acta. 271: 436.
Petzoldt, U., Dames, W., Grottschweski, G.H.M, and Neuhoff, V. 1972. Cytobiology 5: 272.
Beier, H.M., Bohn, H., and Muller, W. 1975 Cell Tissue Res. 165: 1.
Kirchner, C. 1976. Cell Tissue Res. 170: 415.
Kirchner, C., and Schroer, H.G. 1976. J. Reprod. Fertil. 47: 325.
Noske, I.G., Feigelson, M. 1976 Biol. Reprod. 15: 704.
Kikukawa, T., and Mukherjee, A.B. 1989. J. Cell Mol. Endocrinol. 62: 177.
Nieto, A., Ponstingl, H., and Beato, M. 1977. Arch. Biochem. Biophys. 180: 82.
Ponstingl, H., Nieto, A, and Beato, M. 1978. Biochemistry 17: 3908.
Popp, R.A., Foresman, K.R., Wise, L.D., and Daniel, Jr., J.C. 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5516.
Atger, M., Mercier, J.C., Haze, G., Fridlansky, F., and Milgrom, E. 1979. Biochem. J. 177: 985.
Mornon, J.P., Fridlansky, F., Bally, R., and Milgrom, E. 1980. J. Mol. Biol. 127: 415.
Morize, I., Surcouf, E., Vaney, M.C., Epelboin, Y., Buehner, M., Fridlansky, R., Milgrom E., and Mornon, J.P., 1987. J. Mol. Biol. 194: 725.
Aumuller, G., Seitz, J., Heyns, W., and Kirchner, C. 1985. Histochemistry 83: 413.
Warembourg, M., Tranchant, O., Atger, M., and Milgrom, E. 1986. Endocrinology 119: 1632.
Mayol, R.F., and Longenecker, D.E. 1974. Endocrinology 95: 1534.
Shirai, E., Izuka, R., and Notake, Y. 1972. Fertil. Steril. 23: 522.
Daniel, Jr. J.C. 1971. Adv. Biosci. 6: 191.
Daniel, Jr. J.C. 1972. Fertil. Steril. 23: 522.
Wolf, D.P., and Mastroianni, Jr. L. 1975. Fertil. Steril. 26: 240.
Voss, H.G., and Beato, M. 1977. Fertil. Steril. 28: 972.
Cowan, B.C., North, D.H., Whitworth, N.S., Fujita, R., Schumacher, U.K., and Mukherjee, A.B. 1986. Fertil. Steril. 45: 820.
Kikukawa, T., Cowan, B.C., Tejada, R.I., and Mukherjee, A.B 1988. J. Clin. Endocrinol. Metab. 67: 315.
Dhannireddy, R., Fujita, R., and Mukherjee, A.B. 1988 Biochem Biophys. Res. Commun. 152: 1447.
Manyak, M., Kikukawa, T., and Mukherjee, A.B. 1988, J. Urol. 140: 176.
Miele, L., Cordella-Miele, E., and Mukherjee, A.B. 1987. Endocrine Rev. 8: 474.
Challis, J.R.G., Davies, I.J., and Ryan, K.J. 1973. Endocrinol. 93: 971.
Janne, O., Isomaa, V.V., Torkkeli, T.K., Isotalo, H.E., and Kopu, H.T. 1983. In: Wayne Bardin, C., Milgrom, E., and Mauvais-Jarvis, P. (eds) Progesterone and Progestins. Raven Press New York, p 33.
Chilton, B. S., Mani, S. K. and Bullock, D. W. 1988. Mol. Endocrinol. 2: 1169.
Goswami, A., and Feigelson, M. 1974. Endocrinology 95: 669.
Bochskanl, R., and Kirchner, C. 1981. Wilh. Roux Arch. Dev. Biol. 190: 127.
Mukherjee, A. B., Cordella-Miele, E., Kikukawa, T., and Miele, L. 1988. In: Zappia, V., Galletti, P., Porta R., and Wold, F. (eds) Advances in Post-translational Modifications of Proteins and Ageing. Plenum Publishing, New York, pp. 135–152.
Mukherjee, A.B., Laki, Ki, and Agrawal, A. K. 1980. Med. Hypoth. 6: 1043.
Siiteri, P.K., Febris, F., Clemens, L.E., Chang, R.J., Gondos, B., and Stites, D. 1977. Ann. N.Y. Acad. Sci. 286: 384.
Mukherjee, D.C., Ulane, R.E., Manjunath, R., and Mukherjee, A.B. 1983. Science 219: 989.
Mukherjee, A.B., Ulane, R.E., and Agrawal, A.K. 1982. Amer. J. Reprod. Immunol. 2: 135.
Mukherjee, A.B., Cunningham, D., Agrawal, A.K., and Manjunath, R. 1982. Ann. N.Y. Acad. Sci. 392: 401.
Manjunath, R., Chung, S.I., and Mukherjee, A.B. 1984. Biochem. Biophys. Res. Commun. 121: 400.
Schiffman, E., Geetha, V., Pencev, D., Warabi, H., Mato, J., Hirata, F., Brownstein, M., Manjunath, R., Mukherjee, A.B., Liotta, L., and Terranova, V.P. 1983. In: Keller, H., Till E.D. (eds) Agents and Actions Supplements. Birkhauser Verlag, Basel, Vol. 12: 106.
Schiffman, E., Geetha, V., Pencev, D., Mato, J., Garcia-Castro, I., Chiang, P.K., Manjunath R. and Mukherjee, A.B. 1984. In: Kay, A.B., Frank Austen K., Lichtenstein, L.M. (eds). Asthma: Physiology, Immunopharmacology and treatment. Third International Symposium. Academic Press, London, p. 173.
Vasanthakumar, A., Manjunath, R., Mukherjee, A.B., Warabi, H., and Schiffman, E. 1988. Biochem. Pharmacol. 37: 389.
Manjunath, R., Levin, S.W., Kumaroo, K.K., Butler, J.DeB., Donlon, J., McDonald, H., Fujita, R, Schumacher, U.K., and Mukherjee, A.B. 1987. Biochem. Pharmacol. 36: 741.
Flower, R.J., and Blackwell, G.J. 1979. Nature 275: 456.
Hirata, F., Schiffman, E., Venkatasubramanian, K., Solomon, D. and Axelrod, J.A. 1980. Proc. Natl. Acad. Sci. USA 77: 2535.
DiRosa, M., Flower, R. J., Hirata, F., Parente, L., and Russo-Marie, F. 1984. Prostaglandins 28: 441.
Levin, S.W., Butler, J. DeB, Schumacher, U.K., Wightman, P.D., and Mukherjee, A.B. 1986. Life Sci. 38: 1813.
Benveniste, J. and Pretolani, M. 1985. In: Russo-Marie, F., Mencia-Huerta J.M., and Chignard, M. (eds). Advances in Inflammation. Research. Raven Press, New York, Vol. 10: 7.
Bourne, H. R. 1989. Nature 337: 504.
Gramzow, M., Schroeder, H., Fritsche, U., Kurelec, B., Robitzki, A., Zimmermann, H., Friese, K., Kreuter, M. H., and Muller, W. E. G. 1989. Cell 59: 939.
Guinea, R., Lopez-Rivas, A., and Carrasco, L. 1989. J. Biol. Chem. 264: 21923.
Wallner, B. P., Mattaliano, R.J., Hession, C., Cate, R. L., Tizard, R., Sinclair, L. K., Foeller, C., Chow, E. P., Browning, J. L., Ramachandran, K. L., Pepinsky, R. B. 1986. Nature 320: 77.
Crompton, M. R., Moss, S. E. and Crumpton, M. J. 1988. Cell 55: 1.
Miele, L., Cordella-Miele, E., Facchiano, A., and Mukherjee, A. B. 1988. Nature 335: 726.
Weber, K., and Johnson, N. 1986 FEBS Lett. 203: 95.
Geisow, M.J. 1986 Febs Lett. 203: 99.
Wilbur, W.J., and Lipman, D.J. 1983. Proc. Natl. Acad. Sci. USA. 80: 726.
Cirino, G., Flower, R.J., Browning, J.L., Sinclair, L.K., and Pepinsky, R.B. 1987. Nature, 328: 270.
Davidson, F.F., Dennis E.A., Powell, M., and Glenney, J.R. Jr. 1987. J. Biol. Chem. 262: 1698.
Haigler, H.T., Schlaepfer, D.D., and Burgess, W.H. 1987 J. Biol. Chem. 262: 6921.
Slotboom, A. J., Verger, R., Verheij, H. M., Baartsman, P. H. M., Van Deenen, L. L. M., and De Haas, G. H. 1976. Chem. Phys. Lipids 17: 128.
Deems, R. A., Eaton, B., and Dennis, E. A. 1975. J. Biol. Chem. 250: 9013.
Lutz, R. A., Bull, C. and Rodbard, D. 1986. Enzyme 36: 197.
Romero, G., Thompson, K. and Biltonen, R. L. 1987. J. Biol. Chem. 262: 13476.
Gheriani-Gruszka, N., Almog, S., Biltonen, R. L. and Lichtenberg, D. 1988. J. Biol. Chem. 263: 11808.
Bell, J. D. and Biltonen, R. L. 1989. J. Biol. Chem. 264: 12194.
Cho, W., Tomasselli, A. G., Heinrikson, R. L. and Kezdy, F. J. 1988. J. Biol. Chem. 263: 11237.
Tomasselli, A. G., Hui, J., Fisher, J., Zurcher-Neely, H., Reardon, I. M., Oriaku, E., Kezdy, F. J. and Heinrikson, R. L. 1989. J. Biol. Chem. 264: 10041.
Camussi, G., Tetta, C., Bussolino, F., and Baglioni, C. 1990. J. Exp. Med. 171: 913.
Chan, C., Ni, M., Miele, L., Mukherjee, A. B., Nussenblatt, R. B. 1990. 5th International Symposium on the Immunology and Immunopathology of the Eye. Tokyo, March 13–15, 1990.
Ialenti, A., Doyle, P. M., Hardy, G. N., Simpkin, D. S. E., and DiRosa, M. 1990. Agents and Actions 29: 48.
Vostal, J., Mukherjee, A. B., Miele, L., and Shulman, N. R. 1989. Biochem. Biophys. Res. Commun.165: 27.
Sudhoff, T.C., Slaughter, C.A., Leznicki, I., Barion, P., and Reynolds, G.A. 1988. Proc. Natl. Acad. Sci. USA 85: 664.
Kretsinger, R. H., and Creutz, C. E. 1986. Nature 320: 573.
Davidson, F. F., Lister, M. D., and Dennis, E. A. 1990. J. Biol Chem. 265: 5602.
Ahn, N. G., Teller, D. C., Bienkowski, M. J., McMullen, B. A., Lipkin, E. W., and De Haen, C. 1988. J. Biol. Chem. 263: 18657.
Errasfa, M., Bachelet, M., and Russo-Marie, F. 1988. Biochem. Biophys. Res. Commun. 153: 1267.
Cirino, G., Peers, S. H., Flower, R. J., Browning, J. L., and Pepinsky, R. B. 1989. Proc. Natl. Acad. Sci. USA 86: 3428.
Drust, D. S., and Creutz, C. E. 1988. Nature 331: 88.
Hirata, F. 1983. Adv. Prostaglandin, Thromboxane, Leukotriene Res. 11: 73.
Pepinsky, R. B., Tizard, R., Mattaliano, R., Sinclair, L. K., Miller, G. L., Browning, J. L., Chow, E. P., Burne, C., Huang, K., Pratt, D., Watcher, L., Hession, C., Frey, A.Z., and Wallner, B. P., 1988. J. Biol. Chem. 263: 10799.
Creutz, C. E., Zaks, W. J., Hamman, H.C., Crane, S., Martin, W. H., Gould, K. L., Oddie, K. M., and Parsons, S. J. 1987. J. Biol. Chem. 262: 1860.
Nakano, T., Hanasaki, K. and Arita, H. 1989. J. Biol. Chem. 264: 5400.
Metafora, S., Facchiano, F., Facchiano, A., Esposito, C., Peluso, G., and Porta, R. 1987. J. Prot. Chem. 6: 353.
Porta, R., Esposito, C., Persico, P., Peluso, G. and Metafora, S. 1988. In: Zappia, V., Galletti, P., Porta, R., and Wold, F., (eds). Advances in Posttranslational modification of Proteins and Aging. Plenum Press, New York. Vol. I.
Paonessa, G., Metafora, S., Tajana, G., Abrescia, P., De Santis, A., Gentile, V. and Porta, R. 1984. Science 226: 852.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Miele, L., Cordella-Miele, E., Facchiano, A., Mukherjee, A.B. (1990). Inhibition of Phospholipase A2 by Uteroglobin and Antiflammin Peptides. In: Mukherjee, A.B. (eds) Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors. Advances in Experimental Medicine and Biology, vol 279. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0651-1_9
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0651-1_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7910-5
Online ISBN: 978-1-4613-0651-1
eBook Packages: Springer Book Archive