Biochemistry, Molecular Biology, and Physiology of Phospholipase A2 and Its Regulatory Factors

  • Anil B. Mukherjee

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 279)

Table of contents

  1. Front Matter
    Pages i-viii
  2. K. B. Ward, N. Pattabiraman
    Pages 23-36
  3. Robert L. Heinrikson, Ferenc J. Kézdy
    Pages 37-47
  4. Theordore L. Hazlett, Raymond A. Deems, Edward A. Dennis
    Pages 49-64
  5. O. P. Kuipers, C. J. van den Bergh, H. M. Verheij, G. H. de Haas
    Pages 65-84
  6. Rodney L. Biltonen, Thomas R. Heimburg, Brian K. Lathrop, John D. Bell
    Pages 85-103
  7. Eleonora Cordella-Miele, Lucio Miele, Simone Beninati, Anil B. Mukherjee
    Pages 105-123
  8. Thomas Hoffman, Clara Brando, Elaine F. Lizzio, Crystal Lee, Michael Hanson, Karen Ting et al.
    Pages 125-136
  9. Lucio Miele, Eleonora Cordella-Miele, Antonio Facchiano, Anil B. Mukherjee
    Pages 137-160
  10. Robert Crowl, Cheryl Stoner, Tim Stoller, Yu-Ching Pan, Robert Conroy
    Pages 173-184
  11. Fusao Hirata, Aiko Hirata
    Pages 211-218
  12. R. Franson, R. Raghupathi, M. Fry, J. Saal, B. Vishwanath, S. S. Ghosh et al.
    Pages 219-230
  13. John S. Bomalaski, Mike A. Clark
    Pages 231-238
  14. Back Matter
    Pages 253-264

About this book

Introduction

During the past decade there has been a dramatic expansion of our knowledge on phospholipases in general, and phospholipase A2 (PLA2) in particular. Progress in this field has been evident on many fronts, with novel information rapidly accumulating in the literature regarding the chemistry and molecular biology of this enzyme and its role in many important physiological processes. These include cellular signal transduction via the G-protein cycle, and in the generation of many cellular mediators, such as the platelet activating factor (PAF) and the eicosanoids that participate in the initiation and propagation of inflammation, to mention a few. This symposium was organized to obtain an overview of current investigations on this enzyme from the standpoint of its chemistry, molecular biology and physiology. Another important focus of this symposium concerns the regulation of PLA2, including endogenous and synthetic inhibitors and activators of this enzyme. To review these important areas in PLA2 research we invited scientists who made significant contributions in this field. The papers in this volume are organized to emphasize the recent advances in several areas of investigation, including: (I) the structure and mechanism of action of PLA2, (2) mechanism of activation of PLA2, (3) molecular biology, physiology and endogenous inhibitors of this enzyme and finally, (4) clinical investigations emphasizing the pathophysiological role of this enzyme in human diseases. The first article in this volume is by Dr.

Keywords

DNA Glutamin Peptide biochemistry enzymes molecular aspects molecular biology physiology signal transduction

Editors and affiliations

  • Anil B. Mukherjee
    • 1
  1. 1.National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0651-1
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7910-5
  • Online ISBN 978-1-4613-0651-1
  • Series Print ISSN 0065-2598
  • About this book