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Role of Astroglial Cells in Experimental Allergic Encephalomyelitis

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Trends in Neuroimmunology

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Abstract

Astrocyte reaction is among the prominent events occurring in CNS inflammatory lesions. Such reaction leads to a particular way of scarring resulting in fibrous gliosis. Reactive astrocytes show cell body and nucleus morphology larger than the two major types of astrocytes described in normal nervous tissue.1,2 Reactive astrocytes also contain larger amounts of DNA,3 intermediate filaments,4 glial fibrillary acidic protein (GFAP)5,6 and oxidoreductive enzyme activity.7 These cells probably contribute also to the removal and phagocytosis of degenerating myelin.4 In vivo reactive astrocytes probably originate from normal astrocytes undergoing hyperplasia and hypertrophy1,7−11 However, the inducing signals and the time course of this activation are still unknown.

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Author information

Authors and Affiliations

  1. Department of Neurology, University of Florence, V. le Morgagni 85, 50134, Florence, Italy

    L. Massacesi, F. Sarlo, E. Castigli, J. Olivotto, M. Vergelli & L. Amaducci

  2. Institute> of Neurology, Catholic University, Rome, Italy

    A. L. Abbamondi

Authors
  1. L. Massacesi
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  2. A. L. Abbamondi
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  3. F. Sarlo
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  4. E. Castigli
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  5. J. Olivotto
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  6. M. Vergelli
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  7. L. Amaducci
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Editor information

Editors and Affiliations

  1. University of Cagliari, Cagliari, Italy

    Maria Giovanna Marrosu  & Carlo Cianchetti  & 

  2. University of Padua, Padua, Italy

    Bruno Tavolato

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© 1990 Plenum Press, New York

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Massacesi, L. et al. (1990). Role of Astroglial Cells in Experimental Allergic Encephalomyelitis. In: Marrosu, M.G., Cianchetti, C., Tavolato, B. (eds) Trends in Neuroimmunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0607-8_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0607-8_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7889-4

  • Online ISBN: 978-1-4613-0607-8

  • eBook Packages: Springer Book Archive

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