Abstract
It is well-known that parathyroid hormone [PTH] and vitamin D serve critical roles in divalent ion homeostasis through their actions on kidney and bone. On the other hand, renal production of two dihydroxy metabolites of 25-hydroxyvitaminD3 [25(0H)D3], 1,25-dihydroxyvitaminD3 [1,25(0H)2D3] and 24, 25-dihydroxyvitamin D3[24,25(0H)2D3], is tightly and reciprocally regulated by a number of factors. Of several factors involved in inducing renal 1,25(0H)2D3 production, the most important one is PTH physiologically. This hormone stimulates renal production of 1,25(0H)2D3 through a mechanism involving adenosine 3’,5’ -monophosphate[cAMP]. In contrast, 1,25(0H)2D3 is known to be the sole physiological factors in enhancing renal 24,25(0H)2D3 production. Whether PTH regulates renal 24,25(0H)2D3 production as an independent action besides its stimulatory effect on renal 1,25(0H)2D3 production is still not clear.
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© 1989 Plenum Press, New York
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Shigematsu, T., Kawaguchi, Y., Ogura, Y., Suda, T., Miyahara, T. (1989). Human Parathyroid Hormone Inhibits Renal 24, 25-Dihydroxyvitamin D3 Synthesis by a Mechanism Involving Adenosine 3’, 5’ Monophosphate in Rats. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_35
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DOI: https://doi.org/10.1007/978-1-4613-0567-5_35
Publisher Name: Springer, Boston, MA
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