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New Actions of Parathyroid Hormone

  • Shaul G. Massry
  • Takuo Fujita

Table of contents

  1. Front Matter
    Pages i-xv
  2. First International Conference on New Actions of Parathyroid Hormone

  3. Parathyroid Hormone Secretion, Metabolism and Mode of Action

    1. Front Matter
      Pages 9-9
    2. J. T. Potts Jr., S. Nussbaum, K. Wiren, M. Freeman, T. Igarashi, T. Okasaki et al.
      Pages 11-18
    3. Michael P. Caulfield, Le T. Duong, Michael Rosenblatt
      Pages 19-27
    4. M. F. Attie, S. Goldfarb, M. Fallon, J. Shaker, K. Carmichael
      Pages 29-40
    5. J. E. Zull, J. Chuang, I. Yike, J. Reese, R. Laethem
      Pages 41-49
    6. Michael Rosenblatt, Michael Chorev, Ruth F. Nutt, Michael P. Caulfield, Noboru Horiuchi, Thomas L. Clemens et al.
      Pages 61-67
    7. Keith Hruska, Michael Goligorsky, Ian Reid, Roberto Civitelli, Iris Verod, Yasuo Suzuki et al.
      Pages 69-72
    8. Paula H. Stern, Victoria M. Stathopoulos
      Pages 73-80
    9. Takuo Fujita, Hisamitsu Baba, Toru Yamaguchi, Masashi Nishikawa, Mariko Sase, Masafumi Fukushima et al.
      Pages 81-85
    10. T. J. Martin, B. E. Kemp, J. M. Moseley, L. G. Raisz, L. J. Suva, W. I. Wood
      Pages 87-94
    11. Gideon A. Rodan, Mark Thiede, David D. Thompson, Masaki Noda, Sevgi B. Rodan, Michael Rosenblatt
      Pages 95-99
  4. The Vascular Action of Parathyroid Hormone

  5. Parathyroid Hormone and Muscle

    1. Front Matter
      Pages 163-163
    2. Genaro M. A. Palmieri, Tulio E. Bertorini, David F. Nutting, Abbie B. Hinton
      Pages 165-172
    3. Tulio E. Bertorini
      Pages 173-182
    4. Lester L. S. Mok, May C. M. Yang, Peter K. T. Pang, James C. Thompson, Cary W. Cooper
      Pages 183-191
    5. L. M. Baddour, M. M. Hill, A. B. Hinton, G. M. A. Palmieri
      Pages 193-195
  6. Metabolic Effects of Parathyroid Hormone

    1. Front Matter
      Pages 197-197
    2. T. Drüeke, J.-B. Roullet, B. Lacour
      Pages 199-202
    3. Yoshiki Nishizawa, Hitoshi Tanishita, Hitoshi Goto, Satoshi Hagiwara, Takami Miki, Shuzo Otani et al.
      Pages 203-211
    4. Neil A. Kurtzman
      Pages 247-252
    5. Kazuyuki Itoh, Shigeto Morimoto, Tsunehito Shiraishi, Kazuhisa Taniguchi, Toshio Onishi, Yuichi Kumahara
      Pages 259-264
    6. Klaus Olgaard, Henrik Daugaard, Martin Egfjord, Vibeke Pless, Merete Holm
      Pages 265-270
    7. K. Lindenau, K. Vetter, J. Pfitzner, L. Meyer, I. Kaschube, W. Dutz et al.
      Pages 271-276
    8. P. T. Fröhling, F. Kokot, K. Vetter, F. Krupki, K. Lindenau
      Pages 277-287
    9. Takashi Shigematsu, Yoshindo Kawaguchi, Yoosuke Ogura, Tatsuo Suda, Tadashi Miyahara
      Pages 289-297
  7. Parathyroid Hormone and the Nervous System

    1. Front Matter
      Pages 299-299
    2. Shaul G. Massry, Miroslaw Smogorzewski, Anisul Islam
      Pages 301-316
    3. Cosmo L. Fraser, Allen I. Arieff
      Pages 317-328
    4. S. Morimoto, F. Masugi, T. Hironaka, T. Shiraishi, K. Itoh, H. Yamamoto et al.
      Pages 329-334
    5. Carlo Gennari
      Pages 335-345
  8. Aging and Parathyroid Hormone

    1. Front Matter
      Pages 347-347
    2. Takuo Fujita
      Pages 349-355
    3. Dike N. Kalu
      Pages 357-362
  9. Clinical Topics

    1. Front Matter
      Pages 363-363
    2. Dean T. Yamaguchi, Charles R. Kleeman
      Pages 365-377

About this book

Introduction

Shaul G. Massry Division of Nephrology, The University of Southern California, School of Medicine Los Angeles, California In the last two decades evidence has accumulated indicating that parathyroid hormone may exert a multitude of effects on many cells and a variety of organs beyond its classical targets: the kidney and the bone. These efforts have been spearheaded by nephrologists. The interest of this group of clinicians-scientists stems from the fact that patients with renal failure have secondary hyperparathyroidism and markedly elevated blood levels of PTH (1,2). If this hormone does act on various organs, it becomes plausible that excess blood levels of PTH may be harmful in these patients. Indeed, in an Editorial published in 1977, Massry suggested that the elevated blood levels of PTH in patients with renal failure may exert deleterious effects on many systems and as such may participate in the genesis of many of the manifestations of the uremic syndrome (3). Thus, the essence of the Massry hypothesis is the notion that PTH may act as a major uremic toxin. The search for uremic toxins did not yield successful results. In the last three decades many compounds have been implicated as uremic toxins. However, a cause and effect relationship between these compounds and the manifestations of the uremic syndrome has not been established in most cases.

Keywords

Hydra bone cartilage cells endothelium migration regulation skeletal muscle smooth muscle

Editors and affiliations

  • Shaul G. Massry
    • 1
  • Takuo Fujita
    • 2
  1. 1.University of Southern CaliforniaLos AngelesUSA
  2. 2.Kobe University School of MedicineKobeJapan

Bibliographic information