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Natural Toxins 2 pp 37–62Cite as

Overview of Snake Venom Chemistry

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 391)

Abstract

Snake venom is not composed of single compounds but is a complex mixture of proteins. It is not known exactly how many proteins are present in a venom, but it probably consists of fifty to sixty components. Each protein possesses its own biological activity. A further complication is that composition and activity of a snake venom vary among the species. In general, the closer the phylogenetic relationship of the snakes, the more similar are the venom properties and composition.

Keywords

  • Nerve Growth Factor
  • Acetylcholine Receptor
  • Snake Venom
  • Fibrin Clot
  • Fibrinolytic Enzyme

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Abo, V., Viera, L., Silveira, R., and Dajas, F. (1989). Effects of local inhibition of locus caeruleus acetyl-cholinesterase by fasciculin in rats. Neurosci. Lett98: 253–257.

    PubMed  CrossRef  CAS  Google Scholar 

  • Aird, S. D., Kaiser, I.I., Lewis, R. V, and Kruggel, W. G. (1985). Rattlesnake presynaptic neurotoxins: Primary structure and evolutionary origin of the acidic subunit. Biochemistry24: 7054–7058.

    PubMed  CrossRef  CAS  Google Scholar 

  • Aird, S. D., Kaiser, I. I., Lewis, R. V, and Kruggel, W. G. (1986). A complete amino acid sequence for the basic subunit of crotoxin. Arch. Biochem. Biophys. 249: 296–300.

    CAS  Google Scholar 

  • Aird, S. D., Middaugh, C. R., and Kaiser, I. I. (1989b). Spectroscopic characterization of textilotoxin, a presynaptic neurotoxin from the venom of the Australian eastern brown snake (Pseudonaja t. textilis). Biochim. Biophys. Acta997: 219–223.

    CrossRef  CAS  Google Scholar 

  • Aird, S. D., Steadman, B. L., Middaugh, C. R., and Kaiser, L.L. (1989a). Comparative spectroscopic studies of four crotoxin homologies and their subunits. Biochim. Biophys. Acta997: 211–218.

    CrossRef  CAS  Google Scholar 

  • Aird, S. D., Yates, J. R. III, Martino, P. A., Shabanowitz, J., Hunt, D. F., and Kaiser, I. I. (1990). The amino acid sequence of the acidic subunit B-chain of crotoxin. Biochim. Biophys. Acta 1040: 217–224.

    CAS  Google Scholar 

  • Alvarez, J., and Garcia-Sancho, J. (1989). Inhibition of red cell Ca2+-dependent K+ channels by snake venoms. Biochim. Biophys. Acta980: 134–138.

    PubMed  CrossRef  CAS  Google Scholar 

  • Anderson, A. J., and Harvey, A. L. (1988). Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. Br. J. Pharmacol93: 215–221.

    PubMed  CAS  Google Scholar 

  • Anderson, A. J., Harvey, A. L., and Mbugua, P. M. (1985). Effects of fasciculin 2, an anticholinesterase polypeptide from green mamba venom, on neuromuscular transmission in mouse diaphragm preparations. Neurosci. Lett54: 123–128.

    PubMed  CrossRef  CAS  Google Scholar 

  • Benishin, C. G., Sorensen, R. G., Brown, W. E., Krueger, B. K., and Blaustein, M. P. (1988). Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Mol. Pharmacol34: 152–159.

    PubMed  CAS  Google Scholar 

  • Benoit, E., and Dubois, J. M. (1986). Toxin I from the snake Dendroaspis polylepis polylepis: A highly specific blocker of one type of potassium channel in myelinated nerve fiber. Brain Res. 377: 374–377.

    PubMed  CrossRef  CAS  Google Scholar 

  • Betzel, C, Lange, G., Pal, G.-P, Wilson, K. S., Maelicke, A., and Saenger, W. (1991). The refined crystal structure of a-cobratoxin from Naja naja siamensisat 2.4-Å resolution. J. Biol. Chem266: 21530–21536.

    PubMed  CAS  Google Scholar 

  • Bhaskaran, R., Huang, C. C, Chang, D. K., and Yu, C. (1994). J. Mol Biol235: 1291–1306.

    PubMed  CrossRef  CAS  Google Scholar 

  • Bieber, A. L., Tu, T., and Tu, A. T. (1975). Studies of an acidic cardiotoxin isolated from the venom of Mojave rattlesnake (Crotalus scutulatus). Biochim. Biophys. Acta400: 178–188.

    PubMed  CAS  Google Scholar 

  • Bjarnason, J. B., and Tu, A. T. (1978). Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox)venoms: Isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry17: 3395–3404.

    CrossRef  CAS  Google Scholar 

  • Black, A. R., Breeze, A. L., Othman, I. B., and Dolly, J. O. (1986). Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain. Biochem. J237: 397–404.

    PubMed  CAS  Google Scholar 

  • Black, A. R., Donegan, CM., Denny, B. J., and Dolly, J. O. (1988). Solubilization and physical characterization of acceptors for dendrotoxin and ß-bungarotoxin from synaptic membranes of rat brain. Biochemistry27: 6814–6820.

    PubMed  CrossRef  CAS  Google Scholar 

  • Bolioli, B., Castello,M. E., Jerusalinsky, D., Rubinstein, M., Medina, J., and Dajas, F. (1989). Acetylcholinesterase inhibition by fasciculin in rats. Brain Res504: 1–6.

    CAS  Google Scholar 

  • Bon, C, Changeux, J. R, Jeng, T. W., and Fraenkel-Conrat, H. (1979). Postsynaptic effects of crotoxin and of its isolated subunits. Eur. J. Biochem99: 471–481.

    PubMed  CrossRef  CAS  Google Scholar 

  • Busch, A. E., Kavanaugh, M. P., Osborne, P. B., North, R. A., and Adelman, J. P. (1991). Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels. Mol. Pharmacol40: 572–576.

    PubMed  Google Scholar 

  • Cate, R. L., and Bieber, A. L. (1978). Purification and characterization of Mojave (Crotalus scutulatus scutulatus)toxin and its subunits. Arch. Biochem. Biophys189: 397–408.

    PubMed  CrossRef  CAS  Google Scholar 

  • Cervenansky, C, Dajas, F., Harvey, A. L., and Karlsson, E. (1991). Fasciculins, anticholinesterase toxins from mamba vneoms: Biochemistry and pharmacology. In Snake Venoms( A. L. Harvey, ed.), Pergamon Press, New York, pp. 303–321.

    Google Scholar 

  • Chang, C. C, Kawata, Y, Sakiyama, F., and Hayashi, K. (1990). The role of an invariant tryptophan residue in a-bungarotoxin and cobrotoxin. Investigation of active derivatives with the invariant tryptophan replaced by kynurenine. Eur. J. Biochem193: 567–572.

    PubMed  CrossRef  CAS  Google Scholar 

  • Chang, L. S., and Yang, C. C. (1988). Role of the N-terminal region of the A chain in ß,-bungarotoxin fromthe venom of Bungarus multicinctus(Taiwan-banded krait). J. Protein Chem7: 713–726.

    PubMed  CrossRef  CAS  Google Scholar 

  • Chwetzoff, S., Mollier, P., Bouet, F., Rowan, E. G., Harvey, A. L., and Ménez, A. (1990). On the purification of notexin. Isolation of a single amino acid variant from the venom of Notechis scutatus scutatus. FEBSLett. 261: 226–230.

    CrossRef  CAS  Google Scholar 

  • Dajas, F., Bolioli, B., Castello, M. E., and Silveira, R. (1987). Rat striatal acetylcholinesterase inhibition byfasciculin (a polypeptide from green mamba snake venom). Neurosci. Lett77: 87–91.

    PubMed  CrossRef  CAS  Google Scholar 

  • Danse, J.-M., and Gamier, J.-M. (1990). cDNA deduced aminoacid sequences of two novel kappa-neurotoxins from Bungarus multicinctus. Nucleic Acids Res. 18: 1050.

    Google Scholar 

  • Ducancel, F., Boulain, J.-C, Trémeau, O., and Ménez, A. (1989). Direct expression of E. coliof a functionally active protein A — snake toxin fusion protein. Protein Eng. 3: 139–143.

    PubMed  CrossRef  CAS  Google Scholar 

  • Fabiano, R. J., and Tu, A. T. (1981). Purification and biochemical study of viriditoxin, tissue damaging toxin, from prairie rattlesnake venom. Biochemistry20: 21–27.

    PubMed  CrossRef  CAS  Google Scholar 

  • Faure, G., Guillaume, J. L., Camoin, L., Saliou, B., and Bon, C. (1991). Multiplicity of acidic subunit isoforms of crotoxin, the phospholipase A2 neurotoxin from Crotalus durissus terrificusvenom, results from post translational modifications. Biochemistry30: 8074–8083.

    PubMed  CrossRef  CAS  Google Scholar 

  • Gourdou, I., Mabrouk, K., Harkiss, G., Marchot, P., Watt, N., Hery, F., and Vigne, R. (1990). Neurotoxicity in mice due to cysteine-rich parts of visna virus and HIV-1 tatproteins. C. R. Acad. Sci7 /7311: 149–155.

    Google Scholar 

  • Harvey, A. L., and Karlsson, E. (1980). Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps. A neurotoxin that enhances acetylcholine release of neuromuscular junctions. Naunyn Schmiedebergs Arch. Pharmacol312: 1–6.

    PubMed  CrossRef  CAS  Google Scholar 

  • Hawgood, B., and Bon, C. (1991). Snake venom presynaptic toxins. Handbook Natural Toxins5: 3–52.

    Google Scholar 

  • Hendon, R. A., and Tu, A. T. (1979). The role of crotoxin subunits in tropical rattlesnake neurotoxic action. Biochim. Biophys. Acta578: 243–252.

    PubMed  CAS  Google Scholar 

  • Hite, L. A., Shannon, J. D., Bjarnason, J. B., and Fox, J. W. (1992). Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin efrom Crotalus atrox: Evidence for signal, zymogen, and disintegrin-like structure. Biochemistry31: 6203–6211.

    PubMed  CrossRef  CAS  Google Scholar 

  • Itoh, N., Tanaka, N., Mihashi, S., and Yamashina, I. (1987). Molecular cloning and sequence analysis of cDNA bfor batroxobin, a thrombin-like snake venom enzyme. J. Biol. Chem262: 3132–3135.

    PubMed  CAS  Google Scholar 

  • Jeng, T. W., Hendon, R. A., and Fraenkel-Conrat, H. (1978). Search for the relationship among the hemolytic, phospholipolytic and neurotoxic activities of snake venoms. Proc. Natl. Acad. Sci. USA75: 600–604.

    PubMed  CrossRef  CAS  Google Scholar 

  • Joubert, F. J., and Strydom, D. J. (1978). Snake venoms: The amino acid sequences of trypsin inhibitor E of Dendroaspispolylepispotylepis(black mamba) venom. Eur. J. Biochem87: 191–198.

    PubMed  CrossRef  CAS  Google Scholar 

  • Karlsson, E. D., Mbugua, P., and Rodriquez-Ithurralde, D. (1984). Fasciculins, anticholinesterase toxins from the venom of green mamba Dendroaspis angusticeps. Pharmacol. Ther. 30: 259–276.

    CrossRef  Google Scholar 

  • Kase, R., Kitagawa, H., Hayashi, K., Tanoue, K., and Inagaki, F. (1989). Neutralizing monoclonal antibody specific for a-bungarotoxin. Preparation and characterization of the antibody, and localization of antigenic region of a-bungarotoxin. FEBSLett. 254: 106–110.

    PubMed  CrossRef  CAS  Google Scholar 

  • Komori, Y., and Sugihara, H. (1988). Biological study of muscle degenerating hemorrhagic factor from the venom of Vìpera aspis aspis(aspic viper). Int. J. Biochem20: 1417–1423.

    PubMed  CrossRef  CAS  Google Scholar 

  • Kwong, P. D., Hendrickson, W. A., and Sigler, P. B. (1989). beta- Bungarotoxin. Preparation and characterization of crystals suitable for structural analysis. J. Biol. Chem 264:19349–19353.

    Google Scholar 

  • le Du, M. H., Marchot, P., Bougis, P. E., and Fontecilla-Camps, J. C. (1989). Crystals of fasciculin 2 from green mamba snake venom. Preparation and preliminary x-ray analysis. J. Biol. Chem264: 21401–21402.

    PubMed  Google Scholar 

  • Lee, C. Y, Tsai, M. C, Tsaur, M.-L., Lin, W.-W., Carlsson, F. H. H., and Joubert, F. J. (1985). Pharmacological study on angusticeps-type toxins from mamba snake venoms. J. Pharmacol. Exp. Ther233: 491–498.

    PubMed  CAS  Google Scholar 

  • Le Goas, R., La Plante, S. R., Delsac, M.-A., Guittet, E., Robin, M., Charpentier, I., and Lallemand, J.-Y. (1992). a-Cobratoxin: Proton NMR assignments and solution structure. Biochemistry 31:4867–4875.

    Google Scholar 

  • Lennon, B. W., and Kaiser, L.L. (1990). Isolation of a crotoxin- like protein from the venom of a South American rattlesnake (Crotalus durissus collilineatus). Comp. Biochem. Physiol. 97B: 695–699.

    CrossRef  CAS  Google Scholar 

  • Lin, W. W., Lee, C. Y, Carlsson, F. H. H., and Joubert, F. J. (1987). Anticholinesterase activity of angusticeps-type toxins and protease inhibitor homologues from mamba venoms. Acta Pacific J. Pharmacol2: 79–85.

    CAS  Google Scholar 

  • Liu, C. S., Hsiao, P. W., Chang, C.-S., Tzeng, M. C, and Lo, T. B. (1989a). Unusual amino acid sequence of fasciatoxin, a weak reversibly acting neurotoxin in the venom of the banded krait, Bungarus fasciatus. J. Biochem. (Tokyo)259: 153–158.

    CAS  Google Scholar 

  • Liu, C.-S., Chen, J.-R, Chang, C.-S., and Lo, T.-B. (1989b). Amino acid sequence of a short chain neurotoxin from the venom of banded krait. J. Biochem105: 93–97.

    CAS  Google Scholar 

  • Loring, R. H., Andrews, D., Lane, W., and Zigmond, R. E. (1986). Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors. Brain Res. 385: 30–37.

    PubMed  CrossRef  CAS  Google Scholar 

  • McDowell, R. S., Dennis, M. S., Louie, A., Shuster, M., Mulkerrin, M. G., and Lazarus, R. A. (1992). Mambin, a potent glyco-protein Ilb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins. Biochemistry31: 4766–4772.

    PubMed  CrossRef  CAS  Google Scholar 

  • McLane, K. E., Wu, X., and Conti-Tronconi, B. M. (1990). Identification of a brain acetylcholine receptor a subunit able to bind a-bungarotoxin. J. Biol. Chem265: 9816–9824.

    PubMed  CAS  Google Scholar 

  • Mebs, D., Narita, K., Iwanaga, S., Samejima, Y, and Lee, C. Y. (1971). Amino acid sequence of a-bungarotoxin from the venom oí Bungarus multicinctus. Biochem. Biophys. Res. Commun. 44: 711–716.

    CrossRef  CAS  Google Scholar 

  • Ménez, R., and Ducruix, A. (1990). Preliminary x-ray analysis of crystals of fasciculin 1, a potent acetylcholinesterase inhibitor from green mamba venom. J. Mol. Biol216: 233–234.

    PubMed  CrossRef  Google Scholar 

  • Miller, R. A., and Tu, A. T. (1991). Structure-function relationship of lapemis toxin: A synthetic approach. Arch. Biochem. Biophys291: 69–75.

    PubMed  CrossRef  CAS  Google Scholar 

  • Moczydlowski, E., Lucchesi, K., and Ravindran, A. (1988). An emerging pharmacology of peptide toxins targeted against potassium channels. J. Membr. Biol105: 95–111.

    PubMed  CrossRef  CAS  Google Scholar 

  • Mori, N., and Tu, A. T. (1988a). Isolation and primary structure of the major toxin from sea snake, Acalytophis peronii, venom. Arch. Biochem. Biophys260: 10–17.

    CrossRef  CAS  Google Scholar 

  • Mori, N., and Tu, A. T. (1988b). Amino acid sequence of the minor neurotoxin from Acalytophis peroniivenom. Biol. Chem. Hoppe-Seyler369: 521–526.

    CrossRef  CAS  Google Scholar 

  • Nomoto, H., Nagaki, Y, Ishikawa, M., Shoji, H., and Hayashi, K. (1992). Solid-phase neurotoxin binding assay for nicotinic acetylcholine receptor—changes of the binding ability of the receptor with various treatments. J. Nat. Toxicol1: 33–44.

    CAS  Google Scholar 

  • Nomoto, H., Takahashi, N., Nagaki, Y, Endo, S., Arata, Y, and Hayashi, K. (1986). Carbohydrate structure of acetylcholine receptor from Torpedo californicaand distribution of oligo-saccharides among the subunits. Eur. J. Biochem157: 233–242.

    PubMed  CrossRef  CAS  Google Scholar 

  • Ohta, M., Ohta, K., Nishitani, H., and Hayashi, K. (1987). Primary structure of a-bungarotoxin: Six amino acid residues differ from the previously reported sequence. FEBSLett. 222: 79–82.

    PubMed  CrossRef  CAS  Google Scholar 

  • Ougang, C, Teng, C. M., and Huang, T. F. (1987). Characterization of snake venom principles affecting blood coagulation and platelet aggregation. Asia Pacific J. Pharmacol2: 169–179.

    Google Scholar 

  • Ownby, C. L., Bjarnason, J., and Tu, A. T. (1978). Hemorrhagic toxins from rattlesnake (Crotalus atrox)venom: Pathogenesis of hemorrhage induced by three purified toxins. Am. J. Pathol93: 201–218.

    PubMed  CAS  Google Scholar 

  • Pearson, J. A., Tyler, M. I., Retson, K. V., and Howden, M. E. (1991). Studies on the subunit structure of textilotoxin, a potent presynaptic neurotoxin from the venom of the Australian common brown snake

    Google Scholar 

  • Penner, R., Petersen, M., Pierau, F. K., and Dreyer, F. (1986). Dendrotoxin: A selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurons. Pflugers Arch. 407: 365–369.

    PubMed  CrossRef  CAS  Google Scholar 

  • Peterson, M., Penner, R., Pierau, F. K., and Dreyer, F. (1986). ß-Bungarotoxin inhibits a noninactivating potassium current in guinea pig dorsal root ganglion neurons. Neurosci. Lett68: 141–145.

    CrossRef  Google Scholar 

  • Puu, G., and Koch, M. (1990). Comparison of kinetic parameters for acetylcholine, soman, ketamine and fasciculin towards acetyl-cholinesterase in liposomes and in solution. Biochem. Pharmacol40: 2209–2214.

    PubMed  CrossRef  CAS  Google Scholar 

  • Quillfeldt, J., Raskovsky, S., Dalmaz, C, Dias, M, Huang, C, Netto, C. A., Schneider, F., Izquierdo, I., Medina, J. H., and Silveira, R. (1990). Bilateral injection of fasciculin into the amygdala of rats: Effects on two avoidance tasks, acetylcholinesterase activity, and cholinergic muscarinic receptors. Pharmacol. Biochem. Behav37: 439–444.

    PubMed  CrossRef  CAS  Google Scholar 

  • Radvanyi, F., and Bon, C. (1984). Investigations on the mechanism of action of crotoxin. J. Physiol. (Paris)79: 327–333.

    CAS  Google Scholar 

  • Retzios, A. D., and Markland, F. S. (1988). A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: Effects on various components of the human blood coagulation and fibrinolysis system. Thrombosis Res. 52:541.

    Google Scholar 

  • Rhem, H. (1989). Enzymatic deglycosylation of the dendrotoxin-binding protein. FEBS Lett. 247: 28–30.

    Google Scholar 

  • Rhem, H., and Lazdunski, M. (1988). Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc. Natl. Acad. Sci. USA85: 4919–4923.

    CrossRef  Google Scholar 

  • Rodriguez-Ithurralde, D., Silveira, R., Barbeito, L., and Dajas, F. (1983). Fasciculin, powerful an-tichoinesterase polypeptide from Dendroaspis angusticeps venom. Neurochem. Int 5:267––21–4

    Google Scholar 

  • Rodriguez-Ithurralde, D., Silveira, R., and Dajas, F. (1981). Gel chromatography and anticholinesterase activity of Dendroaspis angusticepsvenom. Braz. J. Med. Sci14: 394.

    Google Scholar 

  • Rowan, E. G., and Harvey, A. L. (1988). Potassium channel blocking actions of betabungarotoxin and related toxin on mouse and frog motor nerve terminals. Br. J. Pharmacol94: 839 – 847.

    PubMed  CAS  Google Scholar 

  • Scheidler, A., Kaulen, P., Brüning, G., and Erber, J. (1990). Quantitative autographic localization of [125I]a-bungarotoxin binding sites in the honeybee brain. Brain Res. 534: 332–335.

    PubMed  CrossRef  CAS  Google Scholar 

  • Schmidt, R. R., Betz, H., and Rehm, H. (1988). Inhibition of ß-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin I, and ethylene glycol bis(ß-aminoethyl ether)-N,N,N\N’-tetraacetic acid. Biochemistiy27: 963–967.

    CrossRef  CAS  Google Scholar 

  • Sheumack, D. D., Spence, I., Tyler, M. I., and Howden, M. E. H. (1990). The complete amino acid sequence of a postsynaptic neurotoxin isolated from the venom of the Australian death adder snake Acanthophis antarcticus. Comp. Biochem. Physiol. 95B: 45–50.

    CrossRef  CAS  Google Scholar 

  • Siigur, E., and Siigur, J. (1991). Purification and characterization of lebetase, a fibrinolytic enzyme from Vipera lebetina(snake) venom. Biochem. Biophys. Acta1074: 223–229.

    PubMed  CAS  Google Scholar 

  • Stansfeld, C. E., Marsh, S. J., Halliwell, J. V, and Brown, D. A. (1986). 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurons by blocking slowly inactivating outward current. Neurosci. Lett 64:299–304.

    Google Scholar 

  • Sunthornandh, P., Matangkasombut, P., and Ratanabanangkoon, K. (1992). Preparation, characterization and immunogenicity of various polymers and conjugates of elapid postsynaptic neurotoxins. Mol. Immunol29: 501–510.

    PubMed  CrossRef  CAS  Google Scholar 

  • Trivedi, A., Kaiser, 1.1., Tanaka, M., and Simpson, L. L. (1989). Pharmacologic experiments on the interaction between crotoxin and the mammalian neuromuscular junction. Pharmacol. Exp. Ther. 251: 490–496.

    Google Scholar 

  • Tsai, I. H., Liu, H. C, and Chang, T. (1987). Toxicity domain in presynaptic toxic phospholipase A2 of snake venom. Biochim. Biophys. Acta916: 94–99.

    PubMed  CrossRef  CAS  Google Scholar 

  • Tu, A. T. (1990). Neurotoxins from sea snake and other vertebrate venoms. In Marine Toxins: Origin, Structure, and Molecular Pharmacology(S. Hall and G. Strinchartz, eds.). ACS Symp. Ser. 418: 336–346.

    CrossRef  Google Scholar 

  • Tu, A. T., and Hong, B. S. (1971). Purification and chemical studies of a toxin from the venom of Lapemis hardwickii (Hardwick’s sea snake). J. Biol. Chem. 246:2112–2119

    Google Scholar 

  • Tu, A. T., Hong, B. S., and Solie, T. N. (1971). Characterization and chemical modifications of toxins isolated from the venoms of the sea snake Laticauda semifasciata, from Philippines. Biochemistry10: 1295–1304.

    PubMed  CrossRef  CAS  Google Scholar 

  • Tu, A. T., Jo, B. H., and Yu, N. (1976). Laser Raman spectroscopy of venom neurotoxins: Conformation. Int. J. Peptide Res8: 337–343.

    CrossRef  CAS  Google Scholar 

  • Tu, A. T., and Toom, P. M. (1971). Isolation and characterization of the toxic components of Enhydrina sc his tosa(common sea snake) venom. J. Biol. Chem246: 1012–1016.

    PubMed  CAS  Google Scholar 

  • Tyler, M. I., Barnett, D., Nicholson, P., Spence, I., and Howden, M. E. H. (1987). Studies on the subunit structure of textilotoxin, a potent neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis). Biochim. Biophys. Acta915: 210–216.

    PubMed  CrossRef  CAS  Google Scholar 

  • Utaisincharoen, P., Baker, B., and Tu, A. T. (1991). Binding of myotoxin ato sarcoplasmic reticulum Ca++-ATPase: Astructural study. Biochemistry30: 8211–8216.

    PubMed  CrossRef  CAS  Google Scholar 

  • Valdes, J. J., Thompson, R. G., Wolff, V. L., Menking, D. E., Rael, E.D., and Chambers, J. P. (1989). Inhibition of calcium channel dihydrophyridine receptor binding by purified Mojave toxin. Neurotoxicol. Teratol11: 129–133.

    PubMed  CrossRef  CAS  Google Scholar 

  • Viljoen, C. C, and Botes, D. P. (1973). The purification and amino acid sequence of toxin Fvii from Dendroaspis angusticepsvenom. J. Biol. Chem248: 4915–4919.

    PubMed  CAS  Google Scholar 

  • Weller, U., Bernhardt, U., Siemen, D., Dreyer, F., Vogel, W., and Habermann, E. (1985). Electrophysiological and neurobiochemical evidence for the blockade of potassium channel by dendrotoxin. Naunyn-Schmiedebergs Arch. Pharmacol330: 77–83.

    PubMed  CrossRef  CAS  Google Scholar 

  • Westerlund, B., Nordlund, P., Uhlin, U., Eaker, D., and Eklund, H. (1992). The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution. FEBS Lett. 301: 159–164.

    PubMed  CrossRef  CAS  Google Scholar 

  • Willis, T. W., and Tu, A. T. (1988). Purification and biochemical characterization of atroxase, a nonhemorrhagic fibrinolytic protease from western diamondback rattlesnake venom. Biochemistry27: 4769–4777.

    PubMed  CrossRef  CAS  Google Scholar 

  • Yu, C, Lee, C.-S., Chuang, L.-C, Shei, Y.-R., and Wang, C. Y. (1990). Two-dimensional NMR studies and secondary structure of cobrotoxin in aqueous solution. Eur. J. Biochem193: 789–799.

    PubMed  CrossRef  CAS  Google Scholar 

  • Yu, N., Lin, T., and Tu, A. T. (1975). Laser Raman scattering of neurotoxins isolated from the venoms of sea snakes Lapemis hardwickii schistosa. J. Biol. Chem. 250: 1782–1785.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, 80523-1870, USA

    Anthony T. Tu

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  1. University of Massachusetts, Dartmouth, North Dartmouth, Massachusetts, USA

    Bal Ram Singh

  2. Colorado State University, Fort Collins, Colorado, USA

    Anthony T. Tu

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© 1996 Plenum Press, New York

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Tu, A.T. (1996). Overview of Snake Venom Chemistry. In: Singh, B.R., Tu, A.T. (eds) Natural Toxins 2. Advances in Experimental Medicine and Biology, vol 391. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0361-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0361-9_3

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