Natural Toxins 2

Structure, Mechanism of Action, and Detection

  • Bal Ram Singh
  • Anthony T. Tu

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 391)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Overview of Toxins

    1. Paul J. Scheuer
      Pages 1-8
    2. Gary D. Manners
      Pages 9-35
    3. Anthony T. Tu
      Pages 37-62
  3. Origin, Stucture and Function

    1. Carl-Wilhelm Vogel, Reinhard Bredehorst, David C. Fritzinger, Thomas Grunwald, Patrick Ziegelmüller, Michael A. Kock
      Pages 97-114
    2. Gregory A. Bohach, Cynthia V. Stauffacher, Douglas H. Ohlendorf, Young-In Chi, Gregory M. Vath, Patrick M. Schlievert
      Pages 131-154
    3. Lourdes J. Cruz
      Pages 155-167
    4. Donald R. Hoffman
      Pages 169-186
    5. H. Nakagawa, H. Hashimoto, H. Hayashi, M. Shinohara, K. Ohura, E. Tachikawa et al.
      Pages 213-223
    6. B. Auddy, A. Gomes
      Pages 225-229
    7. B. G. Stiles, T. Krakauer, P. F. Bonventre
      Pages 245-250
    8. Masahiro Nagahama, Sadayuki Ochi, Keiko Kobayashi, Jun Sakurai
      Pages 251-255

About this book

Introduction

From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation­ ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus­ cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Keywords

bacteria biology enzymes natural product safety toxicity

Editors and affiliations

  • Bal Ram Singh
    • 1
  • Anthony T. Tu
    • 2
  1. 1.University of Massachusetts, DartmouthNorth DartmouthUSA
  2. 2.Colorado State UniversityFort CollinsUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0361-9
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-8016-0
  • Online ISBN 978-1-4613-0361-9
  • Series Print ISSN 0065-2598
  • About this book