Indian Catfish (Plotosus canius, Hamilton) Venom
India possessed long coastal areas where venomous catfish are abundant. But almost none of these venomous fish species has been touched for detail investigation regarding their venoms and the active components present in the venom. Plotosus Canius is one of such major venomous catfish species that is present in the estuaries of eastern India. Sting of these fish produces intense pain, swelling and gangrene of the affected areas. On experimental animals the venom produced hypertension and respiratory failure, cardiac arrest, neuromuscular blockage and the LD50 was found to be 3.9 mg/kg (ip) in male albino mice (Auddy et al, 1993). An attempt was made to isolate and purify the lethal factor from the crude venom and its probable involvement in pathophysiology.
KeywordsAmmonium Sulphate Lethal Factor Crude Venom Male Albino Mouse Evaluation Dose Effect
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- Auddy B, Alam M I, Gomes A (1993): Pharmacological actions of the venom of the Indian Catfish (Plotosus canius Hamilton). Ind. J Med Res 99: 47–51.Google Scholar
- Bulbring E (1946): Observation of the isolated phrenic nerve diaphragm preparation of the rat. Br J Pharmacol 1: 38–42.Google Scholar
- Burn J H (1952): In Practical Pharmacology ( Blackwell Scientific Publications, Oxford ) p 22.Google Scholar
- Datta A (1980): Studies on Fish venom Ph. D. thesis, University of Calcutta.Google Scholar
- Ginsborg B L, Warriner J (1960): The isolated chick biventer cervicis nerve muscle preparation. Br J Pharmacol 15: 410–411.Google Scholar
- Poh, C. H., Yuen, R., Khoo, H. E., Chung, M., Gwee, M.C.E. and Gopalakrishnakone. P. (1991). Purification and partial characterization of Stonustoxin (lethal factor) from Synaceja horridaVenom. Comp. Biochem. Physiol. 99B, 793–798.Google Scholar
- Weber K, Osborn M (1969): The reliability of molecular weight determination by dodecyl sulphate Polyacrylamide gel electrophoresis. J Biol Chem 224: 4406–4412.Google Scholar