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Pressor Effect of Beta-Adrenergic Blockade and Angiotensin II in Nephrectomized Rats

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Frontiers in Hypertension Research

Abstract

An increase in blood pressure in approximately 11% of patients with essential hypertension was observed by Drayer et al. (1) following short-term therapy with the beta-blocker propranolol. The acute i.v. administration of propranolol in these patients did not decrease cardiac output, and in some of the figures presented a certain amount of increase could be seen (2). This clinical observation is obviously the end result of certain compensatory mechanisms. The readjustment of total peripheral resistance (TPR) to compensate for the decreased cardiac output (2) and an unopposed reactive alpha-sympathetic activity (1) were suggested as explanations for this phenomenon.

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Authors
  1. A. Iaina
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  2. D. Goldfarb
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  3. H. Eliahou
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Editor information

Editors and Affiliations

  1. Cardiovascular Center, Division of Cardiology, The New York Hospital—Cornell Medical Center, 525 East 68th Street, 10021, New York, New York, USA

    John H. Laragh M.D. (Hilda Altshul Master Professor of Medicine Director, Chief) (Hilda Altshul Master Professor of Medicine Director, Chief)

  2. Department of Medicine and Department of Research, University Hospital, 4031, Basel, Switzerland

    Fritz R. Bühler M.D. (Associate Professor of Medicine Director of Hypertension Unit Consultant in Cardiology) (Associate Professor of Medicine Director of Hypertension Unit Consultant in Cardiology)

  3. University of Texas Health Science Center at Dallas, Dallas, Texas, 75216, USA

    Donald W. Seldin M.D., M.A.C.P. (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service) (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service)

  4. Parkland Memorial Hospital, Dallas, Texas, 75216, USA

    Donald W. Seldin M.D., M.A.C.P. (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service) (William Buchanan Professor of Medicine Chairman of External Medicine Chief of Medical Service)

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© 1981 Springer-Verlag New York Inc.

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Iaina, A., Goldfarb, D., Eliahou, H. (1981). Pressor Effect of Beta-Adrenergic Blockade and Angiotensin II in Nephrectomized Rats. In: Laragh, J.H., Bühler, F.R., Seldin, D.W. (eds) Frontiers in Hypertension Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5899-5_73

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  • DOI: https://doi.org/10.1007/978-1-4612-5899-5_73

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5901-5

  • Online ISBN: 978-1-4612-5899-5

  • eBook Packages: Springer Book Archive

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