Ir Genes pp 491-495 | Cite as

Genetic Restriction of Polyclonal Stimulation of B Cell Proliferation by Antigen-Specific T Cell Clones

  • Sachio Kanamori
  • Harley Y. Tse
Part of the Experimental Biology and Medicine book series (EBAM, volume 4)


Since the demonstration of immune response (Ir) gene effects in animal models (1), much interest has been centered on the identification of Ir gene products and the elucidation of the mechanisms of Ir gene functions.Studies using serological reagents, chimeras, lymphocyte functional assays and mutants (2–4) have all demonstrated that Ia is probably the Ir gene product itself. This is not surprising since Ia has been implicated in a number of cellular interaction processes, notably antigen presentation (5) and T-B cell collaboration (6). It is believed that Ia serves as self-recognition molecules in antigen responses and failure of foreign antigens to associate with a given set in Ia specificities results in unresponsiveness (4,7). Other mechanism that involve the generation of suppressor T cells have also been proposed (8).


Cell Clone Spleen Cell Foreign Antigen Phorbol Myristate Acetate Mixed Lymphocyte Reaction 
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  1. 1.
    Benacerraf, B. (1981) Science 212, 1229–1238.PubMedCrossRefGoogle Scholar
  2. 2.
    Lerner, E.A., Matis, L.A., Janeway, Jr., C.A., Jones, P.P. Schwartz, R.H. & Murphy, D.B. (1980) J. Exp. Med. 152, 1085–1101.PubMedCrossRefGoogle Scholar
  3. 3.
    Longo, D.L. & Schwartz, R.H. (1982) Proc. Natl. Acad. Sci. USA 78, 584–518.Google Scholar
  4. 4.
    Lin, S.C., Rosenthal, A.S., Passmore, H.C. & Hansen, T.H. (1981) Proc. Natl. Acad. Sci. USA 78, 6406–6410.PubMedCrossRefGoogle Scholar
  5. 5.
    Rosenthal, A.S. & Shevach, E.M. (1973) J. Exp. Med. 138, 1194–1212.PubMedCrossRefGoogle Scholar
  6. 6.
    Sprent, J. (1978) Immunol. Rev. 41, 108–137.CrossRefGoogle Scholar
  7. 7.
    Rosenthal, A.S. (1978) Immunol. Rev. 41, 108–137Google Scholar
  8. 8.
    Furman, A. & Sercarz E.E. (1981) J. Immunol. 126, 2430–2435.PubMedGoogle Scholar
  9. 9.
    Glimcher, L.H., Longo, D.L., Green, I. & Schwartz, R.H. (1981) J. Exp. Med. 154, 165–1670.CrossRefGoogle Scholar
  10. 10.
    Tse, H.Y. Mond, J.J. & Paul, W.E. (1981) J. Exp. Med. 153, 871–882.PubMedCrossRefGoogle Scholar
  11. 11.
    Sredni, B., Tse, H.Y. & Schwartz, R.H. (1980) Nature 182, 581–583.CrossRefGoogle Scholar
  12. 12.
    Jones, B. & Janeway, Jr. C.A. (1982) Nature 292, 547–549.CrossRefGoogle Scholar
  13. 13.
    Singer, A., Asano, Y., Shigeta, M., Hatcock, K.S., Ahmed, A., Fathman, C. G. & Hodes, R. J. (1982) Immunol. Rev. 64, 137–160.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1983

Authors and Affiliations

  • Sachio Kanamori
    • 1
  • Harley Y. Tse
    • 1
  1. 1.Department of ImmunologyMerck Sharp & Dohme Research LabRahwayUSA

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