Abstract
Viral infection elicits an immune response consisting of multiple populations of immunologically differentiated cells (immunocytes) and multiple populations of soluble immunoglobulins (antibodies). Subject to genetic restrictions, immunocytes recognize and destroy virus-infected cells that display unorthodox surface viral antigens, whereas antibodies react with extracellularly disseminated viruses and neutralize their infective capability. Although each of these immunological elements has its own modus operandi, they are also interdependent: e.g., cytotoxic “killer” cells depend on antibody as a mediator; antibody is synthesized by B-type immunocytes; B cells are “helped” by T-type immunocytes; under certain conditions B cells are suppressed by T cells. Subsequent discussions will unravel the above grossly oversimplified survey of the immune system.
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© 1984 Springer-Verlag New York Inc.
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Mandel, B. (1984). Mechanisms of Virus Neutralization. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_5
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_5
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