Abstract
Studies on the organisation and rearrangement of the human T-cell receptor α chain locus shows that the single constant region gene is associated with multiple joining segments dispersed over a region of at least 20 kb. The locus maps to the long arm of human chromosome 14 at band 14qll. Genomic clones isolated from a cell line derived from a T cell lymphoma with the marker chromosome inv 14 (14qll;q32) showed that one allele has a Jα segment non-productivity rearranged with an α variable region segment but the other allele has a productive rearrangement between an α gene J segment and a variable region from the immunoglobulin locus. This fusion gene occurs at the inversion 14 chromosomal breakpoint. Therefore the inversion chromosome abnormality in this cell line results in the formation of a chimaeric gene comprising both immunoglobul in and T cell receptor DNA segments. The possible relationship of this fused gene to tumour aetiology is discussed.
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Rabbitts, T.H. et al. (1986). A Fusion Gene of Immunoglobulin and T cell Receptor DNA Segments in a Chromosome 14 Inversion of T-cell Leukaemia. In: Feldmann, M., McMichael, A. (eds) Regulation of Immune Gene Expression. Experimental Biology and Medicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-5014-2_14
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DOI: https://doi.org/10.1007/978-1-4612-5014-2_14
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