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Regulation of Immune Gene Expression

  • Editors
  • Marc Feldmann
  • Andrew McMichael

Part of the Experimental Biology and Medicine book series (EBAM, volume 13)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Molecular Basis of MHC

    1. Front Matter
      Pages 1-1
    2. Pila Estess, Ann B. Begovich, Patricia P. Jones, Hugh O. McDevitt
      Pages 3-19
    3. Bernard Mach, Claude de Préval, Pierre Rollini, Jack Gorski
      Pages 43-49
    4. John Trowsdale
      Pages 51-59
    5. Dominique J. Charron, Alain Haziot, Vincent Lotteau, Dominique Neel, Benoit Merlu, Luc Teyton
      Pages 61-72
  3. Molecular Basis of Lymphocyte Activation

    1. Front Matter
      Pages 73-73
    2. C. Terhorst, K. Georgopoulos, P. Gold, H. Oettgen, C. Pettey, D. Ucker et al.
      Pages 75-84
    3. Katsushige Hasegawa, Mitsuo Maruyama, Takashi Fujita, Tetsuo Ohashi, Masanori Hatakeyama, Seijiro Minamoto et al.
      Pages 85-93
    4. Robert F. Siliciano, Ellis L. Reinherz
      Pages 95-110
    5. Suzanne Pont, Anne Regnier-Vigouroux, Philippe Naquet, Michel Pierres
      Pages 111-117
    6. D. A. Cantrell, A. A. Davies, G. Krissansen, M. J. Crumpton
      Pages 119-133
  4. Molecular Analysis of T Cell Receptors

    1. Front Matter
      Pages 135-135
    2. M. M. Davis, C. Goodnow, N. R. J. Gascoigne, T. Lindsten, Y. Chien
      Pages 137-142
    3. M. J. Owen, M. K. L. Collins, A.-M. Kissonerghis, M. J. Dunne, S. John
      Pages 143-153
    4. T. H. Rabbitts, R. Baer, K.-C. Chen, A. Forster, M.-P. Lefranc, S. Smith et al.
      Pages 155-165
    5. Marie Malissen, Candice McCoy, Dominique Blanc, Jeannine Trucy, Christian Devaux, Anne-Marie Schmitt-Verhulst et al.
      Pages 177-183
  5. Antigen Presentation

    1. Front Matter
      Pages 185-185
    2. P. Erb, M. Kennedy, I. Hagmann, P. Wassmer, G. Huegli, W. Fierz et al.
      Pages 187-196
    3. T. Sasazuki, Y. Nishimura, I. Kikuchi, K. Hirayama, K. Tsukamoto, M. Yasunami et al.
      Pages 197-206
    4. A. R. M. Townsend, F. M. Gotch, J. Davey
      Pages 221-224
    5. Jay A. Berzofsky, Kemp B. Cease, Gail K. Buckenmeyer, Howard Z. Streicher, Charles DeLisi, Ira J. Berkower
      Pages 225-234
  6. HLA and Disease

    1. Front Matter
      Pages 235-235
    2. P. J. Morris, S. V. Fuggle, I. V. Hutchinson, A. Ting, K. J. Wood
      Pages 237-247
    3. J. R. Batchelor, A. H. L. Fielder, S. Hing, I. A. Dodi, C. Speirs, G. R. V. Hughes et al.
      Pages 249-255
    4. Marco Londei, Ian Todd, Ricardo Pujol-Borrell, Franco Bottazzo, Marc Feldmann
      Pages 257-271
  7. T Cell Repertoire

    1. Front Matter
      Pages 273-273
    2. D. J. Schendel, M. Diedrichs, J. P. Johnson
      Pages 301-310
  8. Workshop Summaries

    1. Front Matter
      Pages 321-321
    2. Charles A. Janeway Jr., Antonio Coutinho
      Pages 323-327
    3. David R. Webb, Tomio Tada
      Pages 329-334
    4. Maureen Howard, Jacques Theze
      Pages 335-337
    5. C. W. Pierce, A. J. McMichael
      Pages 339-340
    6. B. Malissen, R. N. Germain
      Pages 341-345
    7. Elizabeth Simpson, Eli Sercarz
      Pages 347-349
  9. Back Matter
    Pages 351-359

About this book

Introduction

This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono­ clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive­ ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.

Keywords

Antigen DNA chromosome evolution gene expression genes genetics molecular biology recombination transplantation

Bibliographic information