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Cytogenetics of Solid Tumors

Renal Cell Carcinoma, Malignant Melanoma, Retinoblastoma, and Wilms’ Tumor

  • Chapter
The Human Oncogenic Viruses

Part of the book series: The Oncogenes ((TO))

Abstract

The concept that irregular mitosis and an abnormal genetic constitution in cells play an important role in neoplastic transformation is not a new one. As early as 1890 von Hansemann first observed abnormal mitosis in human carcinomas. Later, a German embryologist named Boveri (1912) proposed his famous hypothesis of malignancy. According to this hypothesis the abnormal distribution of chromatin in a cell is responsible for that cell becoming neoplastic. At that time, even the exact chromosome constitution of normal human cells was not yet known. Boveri’s hypothesis of malignancy, as it is called now, has been described by Wolf (1974) as follows: (1) malignant cells can be derived from normal tissue cells; (2) the cause of the abnormal behavior lies within the tumor cell itself and not in its environment; (3) the tumor cell is a defective cell in the sense that it has lost the properties of a normal cell; (4) typically, each tumor cell originates from one cell (monoclonal origin); and (5) the cells of the malignant tumor contain certain abnormal chromatin. Each process that brings about this variable chromatin constitution would result in the origin of a malignant tumor.

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Albert A. Luderer Howard H. Weetall

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Pathak, S. (1986). Cytogenetics of Solid Tumors. In: Luderer, A.A., Weetall, H.H. (eds) The Human Oncogenic Viruses. The Oncogenes. Humana Press. https://doi.org/10.1007/978-1-4612-5002-9_2

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  • DOI: https://doi.org/10.1007/978-1-4612-5002-9_2

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