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Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma

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Summary

Cytogenetic examinations on multiple peripheral blood cultures of a patient with papillary thyroid carcinoma and hypercalcemia revealed the following features: (1) The average frequency of cells with aberrations was 11.6%, considerably higher than in controls. Among metaphases with chromosomal abnormalities, 4.5% had chromosome-type aberrations. (2) One homolog of chromosome 11 showed a fragile site in the proximal end of the long arm, and in three metaphases the segment distal to the fragile site showed “branched morphology.” (3) The rate of sister chromatid exchanges was within normal limits (8.78/metaphase). (4) The patient's two sons showed 7.0% and 5.0% abnormal metaphases, in the high normal range.

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Authors and Affiliations

  1. Department of Cell Biology, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77030, Houston, TX, USA

    S. Pathak & T. C. Hsu

  2. Department of Medicine, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77030, Houston, TX, USA

    Naguib Samaan

  3. Department of Surgery, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77030, Houston, TX, USA

    Robert C. Hickey

Authors
  1. S. Pathak
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  2. T. C. Hsu
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  3. Naguib Samaan
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  4. Robert C. Hickey
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Pathak, S., Hsu, T.C., Samaan, N. et al. Cytogenetic abnormalities in a patient with hypercalcemia and papillary thyroid carcinoma. Hum Genet 60, 291–293 (1982). https://doi.org/10.1007/BF00303024

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  • DOI: https://doi.org/10.1007/BF00303024

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