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pA2 Analysis I: Schild Plot

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Abstract

The pA2 is a measure of the affinity of a competitive antagonist for its receptor. The determination of the pA2 is made from experiments in which a fixed concentration of the antagonist is used along with graded concentrations of an agonist acting on the same receptor. The presence of the antagonist shifts the agonist dose—response curve to the right as seen in Figure 15.1.

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  • DOI: 10.1007/978-1-4612-4974-0_16
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© 1987 Springer-Verlag New York Inc.

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Tallarida, R.J., Murray, R.B. (1987). pA2 Analysis I: Schild Plot. In: Manual of Pharmacologic Calculations. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4974-0_16

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  • DOI: https://doi.org/10.1007/978-1-4612-4974-0_16

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9380-4

  • Online ISBN: 978-1-4612-4974-0

  • eBook Packages: Springer Book Archive