Manual of Pharmacologic Calculations

1. Front Matter

   Pages i-x

   PDF

2. Introduction

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 1-4

3. Dosage and Cosncentration: Drug Stock Solutions

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 5-7

4. Mean, Standard Deviation, and Confidence Limits

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 7-10

5. Linear Regression I

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 10-13

6. Linear Regression II: Lines through Origin

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 13-15

7. Analysis of the Regression Line

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 16-18

8. Parallel Lines I: Test for Parallelism

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 19-22

9. Parallel Lines II: Construction of Parallel Lines

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 22-26

10. Graded dose—response

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 26-31

11. Quantal Dose—Response: Probits

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 31-34

12. Relative Potency I

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 35-38

13. Relative Potency II: Statistical Analysis (Graded Data)

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 38-44

14. Dissociation Constant I: Agonists

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 44-47

15. Dissociation Constant II: Partial Agonists

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 47-50

16. Dissociation Constant III: Perturbation Methods (Rate Constants in the Drug-Receptor Reaction)

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 50-53

17. pA₂ Analysis I: Schild Plot

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 53-56

18. pA₂ Analysis II: Time-Dependent Method

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 56-58

19. pA₂ Analysis III: Constrained Plot

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 59-61

20. Enzyme Kinetics I: Michaelis—Menten Equation

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 61-63

This book contains a collection of quantitative procedures in common use in pharmacology and related disciplines. It is intended for students and researchers in all fields who work with drugs. Many physicians, especially those concerned with clinical pharmacology, will also find much that is useful. The procedures included may be considered "core" since they are generally applicable to all classes of drugs. Some of the procedures deal with statistics and, hence, have even wider application. In this new edition we have increased the number of procedures from 33 (in the first edition) to 48. Other procedures have been revised and expanded. Yet the basic philosophy of this new edition remains unchanged from the first. That is, the pharmacologic basis of each procedure is presented, along with the necessary formulas and one or more worked examples. An associated computer program is included for each procedure and its use is illustrated with the same worked example used in the text. The discussions of theory and the sample computations are brief and self-contained, so that all computations can be made with the aid of a pocket calculator and the statistical tables contained in Appendix A. Yet it is realized that the proliferation of lower-priced microcom­ puters is likely to mean that more and more readers will utilize a computer for most calculations. Accordingly, we have modified the format of the book to facilitate computer usage.

• Calculation
• Pharmakologie
• pharmacology
• research
• statistics

• Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

  Ronald J. Tallarida

• Department of Pharmacology, Biosearch Inc., Philadelphia, USA

  Rodney B. Murray

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