Abstract
Human growth hormone (GH) is encoded by one member of a small, highly homologous gene family. The expression of these genes is under stringent tissue-specific control. The amino acid sequence of growth hormone, which is synthesized in the pituitary, is 85% homologous to chorionic somatomammotropin (CS, also known as placental lactogen), which is synthesized in the placenta (1), and the mRNA sequences are even more similar (93%) (2,3). Both proteins are major products of the differentiated cells that secrete them. In addition to this tissue-specific level of control, growth-hormone expression is further modulated by a variety of other factors. This is best characterized in the rat, for example, in which glucocorticoids and thyroid hormone synergistically induce growth-hormone expression (4).
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Moore, D.D., Selden, R.F., Prost, E., Ory, D.S., Goodman, H.M. (1987). The Human Growth-Hormone Gene Family. In: Habener, J.F. (eds) Molecular Cloning of Hormone Genes. Molecular Biology and Biophysics. Humana Press. https://doi.org/10.1007/978-1-4612-4824-8_6
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DOI: https://doi.org/10.1007/978-1-4612-4824-8_6
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