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Molecular Cloning of Hormone Genes

  • Joel F. Habener

Part of the Molecular Biology and Biophysics book series (MBB)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Joel F. Habener
    Pages 1-9
  3. Joel F. Habener
    Pages 11-51
  4. Shu Jin Chan
    Pages 53-68
  5. Gerhard Heinrich, Joel F. Habener
    Pages 69-92
  6. Richard H. Goodman, Marc R. Montminy, Malcolm J. Low, Joel F. Habener
    Pages 93-119
  7. David D. Moore, Richard F Selden, Edouard Prost, Daniel S. Ory, Howard M. Goodman
    Pages 121-135
  8. William W. Chin
    Pages 137-172
  9. Dietmar Richter
    Pages 173-206
  10. Michael Uhler, Edward Herbert
    Pages 207-228
  11. Ueli Gubler
    Pages 229-276
  12. Michael G. Rosenfeld, Stuart Leff, Susan G. Amara, Ronald M. Evans
    Pages 277-301
  13. Henry M. Kronenberg
    Pages 303-319
  14. François Rougeon, Jean-Jacques Panthier, Inge Holm, Florent Soubrier, Pierre Corvol
    Pages 321-342
  15. Gerhard Heinrich
    Pages 343-363
  16. Eliot R. Spindel
    Pages 365-390
  17. K. Richter, W. Hoffmann, R. Egger, G. Kreil
    Pages 391-404
  18. Janet Kurjan
    Pages 413-434
  19. Back Matter
    Pages 435-441

About this book

Introduction

The peptide hormones are small proteins that regulate cellular metabolism through their specific interactions with tissues of the endocrine, nervous, and immune systems, as well as in embry­ onic development. During the past ten years, refinements in the techniques of recombinant DNA technology have resulted in the cloning of genes encoding approximately 50 different hormonal and regulatory peptides, including those in which the peptides themselves and the mRNAs encoding the peptides are present in only trace amounts in the tissues of origin. In addition to provid­ ing the coding sequences of recognized hormonal and regulatory peptides, gene sequencing has uncovered new bioactive peptides encoded in the precursor pro hormones that are then liberated along with the hormonal peptides during cellular cleavages of the precursors. The encoding of multiple peptides in a single mono­ cistronic mRNA appears to be a genetic mechanism for the gener­ ation of biologic diversification without requiring amplification of gene sequences. Two of the objectives in the assembly of this book are to pre­ sent, in one volume, the known primary structures of the genes encoding several of the polypeptide hormones and related regulatory peptides, and to provide an account of the various ap­ proaches that have been used to identify and select the cloned genes encoding these polypeptides. The contents of the two in­ troductory chapters are intended to provide the reader with a brief background of the approaches to gene cloning and the struc­ ture and expression of hormone-encoding genes.

Keywords

DNA Peptide biology biosynthesis cloning gene gene expression immune system metabolism physiology protein protein structure proteins tissue transcription

Editors and affiliations

  • Joel F. Habener
    • 1
  1. 1.Laboratory of Molecular Endocrinology and Howard Hughes Medical InstituteMassachusetts General HospitalBostonUSA

Bibliographic information