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5-HT Receptors Coupled to Adenylate Cyclase

  • Chapter
The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

More than 25 years ago, Mansour et al. (1960) measured an increase in adenylate cyclase activity in a particulate preparation from the flatworm, Fasciola hepatica, in response to 5-HT. Until that time, adenylate cyclase activity had been measured mostly in canine tissues, in response to either epinephrine or glucagon (Sutherland and Rail, 1960). The results with 5-HT and the flatworm suggested that cyclic AMP is a more general second messenger than was previously suspected. Despite this auspicious beginning, the study of 5-HT receptors coupled to adenylate cyclase has lagged behind the study of other receptors coupled to adenylate cyclase. The purposes of this review are to identify those tissues in which 5-HT receptors may be either positively or negatively coupled to adenylate cyclase and to assess the pharmacological data concerning these receptors. Wherever possible, the physiological roles of 5-HT receptor-mediated changes in cyclic AMP accumulation will be discussed.

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Authors
  1. Michael De Vivo
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  2. Saul Maayani
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  1. Department of Pharmacology and Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Elaine Sanders-Bush

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De Vivo, M., Maayani, S. (1988). 5-HT Receptors Coupled to Adenylate Cyclase. In: Sanders-Bush, E. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4560-5_5

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