Abstract
Epilepsy is the most common form of neurological disorder except for stroke (Porter, et al., 1987). The disease is a collection of disorders, and a patient may suffer from more than one form of epilepsy. In addition, not all anticonvulsant drugs are effective against all types of seizure. There are two main classes of epileptic seizure, partial and generalized. These two classes of seizure are initiated differently: partial seizures begin at a localized focal point in the brain and spread to surrounding neurons while generalized seizures show no localized initiation point. Control of these two seizure types requires different activity: partial seizures can be controlled by preventing the sudden electrical discharge at the focal point and generalized seizures can be prevented by a general lowering of neuronal reaction.
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Codding, P.W., Duke, N.E., Aha, L.J., Palmer, L.Y., McClurg, D.K., Szkaradzinska, M.B. (1990). Structural and Computational Studies of Anticonvulsants: A Search for Correlation Between Molecular Systematics and Activity. In: Bugg, C.E., Ealick, S.E. (eds) Crystallographic and Modeling Methods in Molecular Design. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3374-9_10
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