Advertisement

Crystallographic and Modeling Methods in Molecular Design

  • Charles E. Bugg
  • Steven E. Ealick

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Thomas J. Smith, John Badger, Marcia Kremer, Marcos Oliveira, Michael G. Rossmann, Mark A. McKinlay et al.
    Pages 9-28
  3. Manuel A. Navia, Brian M. McKeever, James P. Springer
    Pages 29-42
  4. Steven E. Ealick, Y. S. Babu, S. V. L. Narayana, William J. Cook, Charles E. Bugg
    Pages 43-55
  5. J. A. Wozniak, X.-J. Zhang, K. Wilson, L. H. Weaver, D. E. Tronrud, P. E. Pjura et al.
    Pages 80-94
  6. Andrew H.-J. Wang, Mai-Kun Teng
    Pages 123-150
  7. Penelope W. Codding, N. E. Duke, L. J. Aha, L. Y. Palmer, D. K. McClurg, M. B. Szkaradzinska
    Pages 151-160
  8. Barry C. Finzel, S. Kimatian, D. H. Ohlendorf, J. J. Wendoloski, M. Levitt, F. Ray Salemme
    Pages 175-188
  9. T. Alwyn Jones, Marc Bergdoll, Morten Kjeldgaard
    Pages 189-199
  10. Renee L. DesJarlais, Brian Shoichet, George Seibel, Irwin D. Kuntz Jr.
    Pages 200-210
  11. R. Scott Rowland, Frank H. Allen, W. Michael Carson, Charles E. Bugg
    Pages 229-253
  12. Back Matter
    Pages 265-269

About this book

Introduction

This book contains the papers that were presented at the "Crystallo­ graphic and Modeling Methods in Molecular Design Symposium" in Gulf Shores, Alabama, April 30 to May 3, 1989. During the past few years, there has been a burst of activity in this area, especially related to drug design and protein engineering projects. The purpose of the symposium and this book is to provide an up-to­ date review of the most recent experimental and theoretical approaches that are being used for molecular design. The book covers several re­ cent examples of approaches for using crystallography in conjunction with forefront modeling methods for guiding the development of en­ zyme inhibitors and of peptides and proteins with modified biological and physical properties. In addition, this book contains discussions of new approaches for combining crystallographic data and advanced computational techniques for aiding in the design of enzyme inhibitors and other compounds that bind to selected biological targets. This book is therefore of interest not only to molecular biologists and biochem­ ists, but is stimulating reading for anyone involved in structural biol­ ogy, pharmaceutical chemistry, enzymology, protein engineering, and biotechnology. The meeting was the third in a series of symposia initiated and spon­ sored by the Department of Biochemistry, University of Alabama at Birmingham.

Keywords

DNA Purine drug drug design protein protein engineering receptor research

Editors and affiliations

  • Charles E. Bugg
    • 1
  • Steven E. Ealick
    • 1
  1. 1.Department of BiochemistryUniversity of AlabamaBirminghamUSA

Bibliographic information