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Cerebral Circulation of the Fetus and Newborn

  • Chapter
The Human Brain Circulation

Part of the book series: Vascular Biomedicine ((VB))

Abstract

Similar to the adult, the fetal and neonatal cerebral circulations are regulated by four primary factors: metabolic stimuli, perfusion pressure, chemical stimuli, and neural stimuli. However, the relative importance of these factors in regulation of the cerebral circulation in many instances appears to vary with age or developmental stage. The underlying basis for differential responsiveness has to do with considerations such as basal arterial blood gases and arterial blood pressure, completeness of neural development, basal level of brain metabolism, physical features of blood vessels, and characteristics of the blood brain barrier (BBB). I will review recent studies concerning the roles played by chemical, autoregulatory, metabolic, and neural factors in the regulation of cerebral resistance vessels. Further, since neonatal animals are often exposed to several pathophysiological conditions, I will discuss cerebrovascular responses to asphyxia/reventilation, seizures, and hemorrhagic hypotension in neonates.

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Authors
  1. David W. Busija
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Editors and Affiliations

  1. Totman Laboratory for Human Cerebrovascular Research, Department of Pharmacology, University of Vermont, Burlington, Vermont, USA

    Rosemary D. Bevan  & John A. Bevan  & 

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Busija, D.W. (1994). Cerebral Circulation of the Fetus and Newborn. In: Bevan, R.D., Bevan, J.A. (eds) The Human Brain Circulation. Vascular Biomedicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0303-2_20

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  • DOI: https://doi.org/10.1007/978-1-4612-0303-2_20

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6700-3

  • Online ISBN: 978-1-4612-0303-2

  • eBook Packages: Springer Book Archive

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