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Murine Transgenic Models of IDDM

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Molecular Biology of Diabetes

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Abstract

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease. To study the immune responses leading to the breakdown of tolerance to islet β-cells, genes of putative causative agents and of major histocompatibility complex (MHC) are linked to insulin promoter and incorporated into the germ line of a mouse. The expression of transgenes are tissue specific (β-cell-specific) and their actions are analyzed during the life span of the “host” animals. These transgenic mice not only serve as models of IDDM but also provide new powerful tools for studying the many aspects of peripheral tolerance.

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Authors
  1. Danling Gu
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  2. Nora Sarvetnick
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Editor information

Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Boris Draznin MD, PhD

  2. National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, USA

    Derek LeRoith MD, PhD

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© 1994 Springer Science+Business Media New York

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Gu, D., Sarvetnick, N. (1994). Murine Transgenic Models of IDDM. In: Draznin, B., LeRoith, D. (eds) Molecular Biology of Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0241-7_2

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  • DOI: https://doi.org/10.1007/978-1-4612-0241-7_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6677-8

  • Online ISBN: 978-1-4612-0241-7

  • eBook Packages: Springer Book Archive

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